KEGG   ENZYME: 2.3.1.238Help
Entry
EC 2.3.1.238                Enzyme                                 

Name
monacolin J acid methylbutanoate transferase;
LovD
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
monacolin J acid:(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] (S)-2-methylbutanoate transferase
Reaction(IUBMB)
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] = lovastatin acid + [2-methylbutanoate polyketide synthase]
Reaction(KEGG)
(other) R11126
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Substrate
monacolin J acid [CPD:C20854];
(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]
Product
lovastatin acid [CPD:C21130];
[2-methylbutanoate polyketide synthase]
Comment
The enzyme catalyses the ultimate reaction in the lovastatin biosynthesis pathway of the filamentous fungus Aspergillus terreus.
History
EC 2.3.1.238 created 2014
Reference
1  [PMID:10334994]
  Authors
Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR.
  Title
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.
  Journal
Science. 284 (1999) 1368-72.
  Sequence
Reference
2  [PMID:17113998]
  Authors
Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y
  Title
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.
  Journal
Chem. Biol. 13 (2006) 1161-9.
  Sequence
Reference
3  [PMID:19530726]
  Authors
Xie X, Meehan MJ, Xu W, Dorrestein PC, Tang Y
  Title
Acyltransferase mediated polyketide release from a fungal megasynthase.
  Journal
J. Am. Chem. Soc. 131 (2009) 8388-9.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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