KEGG   ENZYME: 2.3.1.60Help
Entry
EC 2.3.1.60                 Enzyme                                 

Name
gentamicin 3-N-acetyltransferase;
gentamycin acetyltransferase I;
aminoglycoside acetyltransferase AAC(3)-1;
gentamycin 3-N-acetyltransferase;
acetyl-CoA:gentamycin-C N3-acetyltransferase;
acetyl-CoA:gentamicin-C N3'-acetyltransferase (incorrect);
gentamicin 3'-N-acetyltransferase (incorrect)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:gentamicin-C N3-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + gentamicin C = CoA + N3-acetylgentamicin C [RN:R03767]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
gentamicin C [CPD:C01918]
Product
CoA [CPD:C00010];
N3-acetylgentamicin C [CPD:C03297]
Comment
Also acetylates sisomicin.
History
EC 2.3.1.60 created 1976, modified 2015
Orthology
K03395  
aminoglycoside 3-N-acetyltransferase I
Genes
ECLE: 
KPZ: 
CFD: 
PANT: 
PANP: 
PMY: 
ABY: 
ABAYE3573(aacC1)
ABN: 
ABX: 
ABZ: 
ABR: 
ABD: 
SDE: 
TGR: 
TKM: 
TTI: 
HCH: 
ADI: 
PSPI: 
AKA: 
VAP: 
VPD: 
PBH: 
MYM: 
AGE: 
SMEG: 
MEX: 
MEA: 
MDI: 
MCH: 
HNI: 
FIL: 
FIY: 
PDE: 
SAL: 
SPHP: 
SMAG: 
AMX: 
PRT: 
ARW: 
PPC: 
SYNE: 
CGC: 
CMP: 
LEP: 
OAC: 
TPX: 
FBT: 
MOD: 
 » show all
Taxonomy
Reference
1  [PMID:6281224]
  Authors
Angelatou F, Litsas SB, Kontomichalou P.
  Title
Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa.
  Journal
J. Antibiot. (Tokyo). 35 (1982) 235-44.
Reference
2  [PMID:820250]
  Authors
Biddlecome S, Haas M, Davies J, Miller GH, Rane DF, Daniels PJ.
  Title
Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.
  Journal
Antimicrob. Agents. Chemother. 9 (1976) 951-5.
Reference
3  [PMID:764855]
  Authors
Williams JW, Northrop DB.
  Title
Purification and properties of gentamicin acetyltransferase I.
  Journal
Biochemistry. 15 (1976) 125-31.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
58500-58-6

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