KEGG   ENZYME: 2.3.2.1Help
Entry
EC 2.3.2.1                  Enzyme                                 

Name
D-glutamyltransferase;
D-glutamyl transpeptidase;
D-gamma-glutamyl transpeptidase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
glutamine:D-glutamyl-peptide 5-glutamyltransferase
Reaction(IUBMB)
(1) D-glutamine + D-glutamate = ammonia + gamma-D-glutamyl-D-glutamate [RN:R04011 R04012];
(2) L(or D)-glutamine + (gamma-D-glutamyl)n-[peptide] = ammonia + (gamma-D-glutamyl)n+1-[peptide]
Reaction(KEGG)
Substrate
D-glutamine [CPD:C00819];
D-glutamate [CPD:C00217];
L-glutamine [CPD:C00064];
(gamma-D-glutamyl)n-[peptide]
Product
ammonia [CPD:C00014];
gamma-D-glutamyl-D-glutamate;
(gamma-D-glutamyl)n+1-[peptide]
Comment
The enzyme catalyses two reactions. The first is the transfer of a glutamyl residue from L- or D-glutamine to D-glutamate via a gamma linkage, forming gamma-glutamyl-D-glutamate, and the second is the transfer of additional glutamyl residues to the peptide, extending the polypeptide chain.
History
EC 2.3.2.1 created 1961, modified 1976, modified 2013
Pathway
D-Glutamine and D-glutamate metabolism
Reference
1  [PMID:13201582]
  Authors
WILLIAMS WJ, THORNE CB
  Title
Biosynthesis of glutamyl peptides from glutamine by a transfer reaction.
  Journal
J. Biol. Chem. 210 (1954) 203-17.
Reference
2  [PMID:13233245]
  Authors
WILLIAMS WJ, LITWIN J, THORNE CB.
  Title
Further studies on the biosynthesis of gamma-glutamyl peptides by transfer reactions.
  Journal
J. Biol. Chem. 212 (1955) 427-38.
  Organism
Bacillus subtilis
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-02-8

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