| Entry |
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| Name |
D-glutamyltransferase;
D-glutamyl transpeptidase;
D-gamma-glutamyl transpeptidase
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| Class |
Transferases;
Acyltransferases;
Aminoacyltransferases
 |
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| Sysname |
glutamine:D-glutamyl-peptide 5-glutamyltransferase
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| Reaction(IUBMB) |
(1) D-glutamine + D-glutamate = ammonia + gamma-D-glutamyl-D-glutamate [RN: R04011 R04012];
(2) L(or D)-glutamine + (gamma-D-glutamyl)n-[peptide] = ammonia + (gamma-D-glutamyl)n+1-[peptide]
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| Reaction(KEGG) |
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| Substrate |
D-glutamine [CPD: C00819];
D-glutamate [CPD: C00217];
L-glutamine [CPD: C00064];
(gamma-D-glutamyl)n-[peptide]
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| Product |
ammonia [CPD: C00014];
gamma-D-glutamyl-D-glutamate;
(gamma-D-glutamyl)n+1-[peptide]
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| Comment |
The enzyme catalyses two reactions. The first is the transfer of a glutamyl residue from L- or D-glutamine to D-glutamate via a gamma linkage, forming gamma-glutamyl-D-glutamate, and the second is the transfer of additional glutamyl residues to the peptide, extending the polypeptide chain.
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| Pathway |
| D-Glutamine and D-glutamate metabolism |
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| Reference |
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| Authors |
WILLIAMS WJ, THORNE CB |
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| Title |
Biosynthesis of glutamyl peptides from glutamine by a transfer reaction. |
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| Journal |
J. Biol. Chem. 210 (1954) 203-17. |
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| Reference |
|
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| Authors |
WILLIAMS WJ, LITWIN J, THORNE CB. |
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| Title |
Further studies on the biosynthesis of gamma-glutamyl peptides by transfer reactions. |
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| Journal |
J. Biol. Chem. 212 (1955) 427-38. |
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| Organism |
Bacillus subtilis [GN: bsu] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9030-02-8 |
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