KEGG   ENZYME: 2.3.2.21Help
Entry
EC 2.3.2.21                 Enzyme                                 

Name
cyclo(L-tyrosyl-L-tyrosyl) synthase;
Rv2275 (gene name);
cYY synthase;
cyclodityrosine synthase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
L-tyrosyl-tRNATyr:L-tyrosyl-tRNATyr tyrosyltransferase (cyclizing)
Reaction(IUBMB)
2 L-tyrosyl-tRNATyr = 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl) [RN:R10335]
Reaction(KEGG)
Substrate
L-tyrosyl-tRNA(Tyr) [CPD:C02839]
Product
tRNA(Tyr) [CPD:C00787];
cyclo(L-tyrosyl-L-tyrosyl) [CPD:C20516]
Comment
The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue [2]. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl) [1].
History
EC 2.3.2.21 created 2013
Orthology
K17484  cyclo(L-tyrosyl-L-tyrosyl) synthase
Genes
MTU: Rv2275
MTV: RVBD_2275
MTC: MT2335
MRA: MRA_2294
MTF: TBFG_12300
MTB: TBMG_01707
MTK: TBSG_01717
MTZ: TBXG_001690
MTG: MRGA327_14020
MTI: MRGA423_14140
MTUR: CFBS_2408
MTD: UDA_2275
MTUC: J113_15835
MTUE: J114_12195
MTUT: HKBT1_2399
MTUU: HKBT2_2401
MBB: BCG_2292
MBT: JTY_2286
MBX: BCGT_2099
MAF: MAF_22850
MMIC: RN08_2522
SVE: SVEN_1864
SALU: DC74_296
SALL: SAZ_01935
SLE: sle_63980(sle_63980)
SESP: BN6_23810
 » show all
Taxonomy
Reference
1  [PMID:19430487]
  Authors
Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courcon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL
  Title
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.
  Journal
Nat. Chem. Biol. 5 (2009) 414-20.
  Sequence
[mtu:Rv2275]
Reference
2  [PMID:20852636]
  Authors
Vetting MW, Hegde SS, Blanchard JS
  Title
The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.
  Journal
Nat. Chem. Biol. 6 (2010) 797-9.
  Sequence
[mtu:Rv2275]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.21
IUBMB Enzyme Nomenclature: 2.3.2.21
ExPASy - ENZYME nomenclature database: 2.3.2.21
BRENDA, the Enzyme Database: 2.3.2.21

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