KEGG   ENZYME: 2.3.2.21Help
Entry
EC 2.3.2.21                 Enzyme                                 

Name
cyclo(L-tyrosyl-L-tyrosyl) synthase;
Rv2275 (gene name);
cYY synthase;
cyclodityrosine synthase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
L-tyrosyl-tRNATyr:L-tyrosyl-tRNATyr tyrosyltransferase (cyclizing)
Reaction(IUBMB)
2 L-tyrosyl-tRNATyr = 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl) [RN:R10335]
Reaction(KEGG)
Substrate
L-tyrosyl-tRNA(Tyr) [CPD:C02839]
Product
tRNA(Tyr) [CPD:C00787];
cyclo(L-tyrosyl-L-tyrosyl) [CPD:C20516]
Comment
The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue [2]. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl) [1].
History
EC 2.3.2.21 created 2013
Orthology
K17484  
cyclo(L-tyrosyl-L-tyrosyl) synthase
Genes
MTU: 
MTV: 
MTC: 
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTJ: 
MTUC: 
MTUE: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
MBB: 
MBT: 
MBM: 
MBK: 
MBX: 
MBZ: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MMIC: 
SCT: 
SCY: 
SVE: 
SALU: 
SALL: 
SVT: 
STRE: 
SLD: 
STRC: 
SCX: 
SRW: 
NAL: 
B005_4463(albC)
SESP: 
KPHY: 
 » show all
Taxonomy
Reference
1  [PMID:19430487]
  Authors
Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courcon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL
  Title
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.
  Journal
Nat. Chem. Biol. 5 (2009) 414-20.
Reference
2  [PMID:20852636]
  Authors
Vetting MW, Hegde SS, Blanchard JS
  Title
The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.
  Journal
Nat. Chem. Biol. 6 (2010) 797-9.
  Sequence
[mtu:Rv2275]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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