KEGG   ENZYME: 2.3.3.6Help
Entry
EC 2.3.3.6                  Enzyme                                 

Name
2-ethylmalate synthase;
(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating);
2-ethylmalate-3-hydroxybutanedioate synthase;
propylmalate synthase;
propylmalic synthase
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Reaction(IUBMB)
acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA [RN:R00998]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
2-oxobutanoate [CPD:C00109]
Product
(R)-2-ethylmalate [CPD:C02488];
CoA [CPD:C00010]
Comment
Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC 2.3.3.7 3-ethylmalate synthase.
History
EC 2.3.3.6 created 1983 as EC 4.1.3.33, transferred 2002 to EC 2.3.3.6
Pathway
Pyruvate metabolism
Reference
1  [PMID:6052435]
  Authors
Strassman M, Ceci LN.
  Title
A study of acetyl-CoA condensation with alpha-keto acids.
  Journal
Arch. Biochem. Biophys. 119 (1967) 420-8.
  Organism
Saccharomyces cerevisiae
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9024-01-5

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