KEGG   ENZYME: 2.4.1.122Help
Entry
EC 2.4.1.122                Enzyme                                 
Name
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase;
uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase;
UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine [RN:R05908]
Reaction(KEGG)
R05908(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
glycoprotein N-acetyl-D-galactosamine
Product
UDP [CPD:C00015];
glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
Comment
The non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins can act as acceptors.
Pathway
Mucin type O-Glycan biosynthesis
Metabolic pathways
Orthology
K00731  
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
Genes
HSA: 
56913(C1GALT1)
PTR: 
472288(C1GALT1)
PPS: 
100977740(C1GALT1)
GGO: 
101145951(C1GALT1)
PON: 
100452461(C1GALT1)
MCC: 
696870(C1GALT1)
MMU: 
94192(C1galt1)
RNO: 
65044(C1galt1)
CFA: 
482314(C1GALT1)
AML: 
100483848(C1GALT1)
FCA: 
101096459(C1GALT1)
BTA: 
539417(C1GALT1)
SSC: 
100525767
SHR: 
100932643(C1GALT1)
OAA: 
100075856
GGA: 
420575(C1GALT1)
MGP: 
100542429
TGU: 
100221974(C1GALT1)
ACS: 
100554192 100562160
XLA: 
444326(c1galt1)
XTR: 
100487794 100496837
DRE: 
337131(c1galt1b) 555344 557675(c1galt1a)
TRU: 
101064009 101071001
OLA: 
101156399 101170759 101171346
BFO: 
BRAFLDRAFT_60136
CIN: 
100182788
SPU: 
581429
DME: 
Dmel_CG9520(C1GalTA)
DPO: 
Dpse_GA21851
DAN: 
Dana_GF15693
DER: 
Dere_GG24047
DPE: 
Dper_GL25549
DSE: 
Dsec_GM12650
DSI: 
Dsim_GD22375
DWI: 
Dwil_GK14790 Dwil_GK14791
DYA: 
Dyak_GE10709
DGR: 
Dgri_GH10852 Dgri_GH23406 Dgri_GH23497 Dgri_GH25080 Dgri_GH25082 Dgri_GH25083 Dgri_GH25123
DMO: 
Dmoj_GI12045
DVI: 
Dvir_GJ14135
AGA: 
AgaP_AGAP009979
AAG: 
AaeL_AAEL007560
CQU: 
CpipJ_CPIJ003116
AME: 
409263
NVI: 
100120600(NV12946)
API: 
100168660
PHU: 
Phum_PHUM258020
ISC: 
IscW_ISCW016807
CEL: 
CELE_C38H2.2(C38H2.2)
CBR: 
CBG18398
TSP: 
Tsp_00464
SMM: 
Smp_149820
NVE: 
NEMVE_v1g89529
HMG: 
100213528
OTA: 
Ot19g00200
MBR: 
MONBRDRAFT_22031
TPS: 
THAPSDRAFT_261140 THAPSDRAFT_262287 THAPSDRAFT_269773
PIF: 
PITG_07926 PITG_08426
 » show all
Taxonomy
Reference
1  [PMID:6789880]
  Authors
Hesford FJ, Berger EG, Van den Eijnden DH.
  Title
Identification of the product formed by human erythrocyte galactosyltransferase.
  Journal
Biochim. Biophys. Acta. 659 (1981) 302-11.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:6801057]
  Authors
Mendicino J, Sivakami S, Davila M, Chandrasekaran EV.
  Title
Purification and properties of UDP-gal:N-acetylgalactosaminide mucin: beta 1,3-galactosyltransferase from swine trachea mucosa.
  Journal
J. Biol. Chem. 257 (1982) 3987-94.
  Organism
Sus scofa [GN:ssc]
Reference
3  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods. Enzymol. 98 (1983) 98-134.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97089-61-7
DBGET integrated database retrieval system