KEGG   ENZYME: 2.4.1.134Help
Entry
EC 2.4.1.134                Enzyme                                 

Name
galactosylxylosylprotein 3-beta-galactosyltransferase;
galactosyltransferase II;
uridine diphosphogalactose-galactosylxylose galactosyltransferase;
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [RN:R05927]
Reaction(KEGG)
R05927(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
Product
UDP [CPD:C00015];
[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [CPD:C04825]
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.134 created 1984, modified 2002
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K00734  galactosylxylosylprotein 3-beta-galactosyltransferase
Genes
HSA: 126792(B3GALT6)
PTR: 457187(B3GALT6)
PPS: 100971409(B3GALT6)
PON: 112135480(B3GALT6)
MCC: 703713(B3GALT6)
MCF: 102115188(B3GALT6)
CSAB: 103225816(B3GALT6)
RRO: 104673226(B3GALT6)
RBB: 108544195(B3GALT6)
CJC: 100387131(B3GALT6)
MMU: 117592(B3galt6)
RNO: 298690(B3galt6)
CGE: 100767598(B3galt6)
NGI: 103749737(B3galt6)
HGL: 101721217(B3galt6)
CCAN: 109681028(B3galt6)
OCU: 103351814(B3GALT6)
TUP: 102502785(B3GALT6)
CFA: 664717(B3GALT6)
AML: 100473227(B3GALT6)
UMR: 103682080(B3GALT6)
ORO: 101364618(B3GALT6)
FCA: 105259949(B3GALT6)
PTG: 102964488(B3GALT6)
AJU: 106978137(B3GALT6)
BTA: 522406(B3GALT6)
BOM: 102265005(B3GALT6)
BIU: 109570568(B3GALT6)
PHD: 102320877(B3GALT6)
CHX: 102191357(B3GALT6)
OAS: 101105768(B3GALT6)
SSC: 100523125(B3GALT6)
CFR: 102522264(B3GALT6)
CDK: 105105583(B3GALT6)
LVE: 103085660(B3GALT6)
OOR: 101276763(B3GALT6)
ECB: 100146417(B3GALT6)
EPZ: 103558570(B3GALT6)
EAI: 106845197(B3GALT6)
HAI: 109391146(B3GALT6)
RSS: 109434784(B3GALT6)
PALE: 102879449(B3GALT6)
LAV: 100659349(B3GALT6)
TMU: 101342110
MDO: 100024991(B3GALT6)
OAA: 100074836(B3GALT6)
GGA: 107057357 428185(B3GALT6)
MGP: 104914138(B3GALT6)
CJO: 107323501(B3GALT6)
APLA: 101798225(B3GALT6)
ACYG: 106044272(B3GALT6)
TGU: 100225099(B3GALT6)
GFR: 102039787(B3GALT6)
FAB: 101808759(B3GALT6)
PHI: 102108353(B3GALT6)
PMAJ: 107213734(B3GALT6)
CCW: 104693401(B3GALT6)
FPG: 101913380(B3GALT6)
FCH: 102056999(B3GALT6)
CLV: 102096830(B3GALT6)
EGZ: 104133398(B3GALT6)
AAM: 106495555(B3GALT6)
ASN: 102373206(B3GALT6)
AMJ: 102571760(B3GALT6)
PSS: 102452076(B3GALT6)
CMY: 102942046(B3GALT6)
CPIC: 101943011(B3GALT6)
PVT: 110073136(B3GALT6)
PBI: 103049964(B3GALT6)
GJA: 107110843(B3GALT6)
XLA: 108696563(b3galt6.L) 108697636(b3galt6.S)
XTR: 548849(b3galt6)
NPR: 108784315(B3GALT6)
DRE: 572324(b3galt6)
IPU: 108255271(b3galt6)
AMEX: 103027814(b3galt6)
TRU: 777996(b3galt6)
LCO: 104939272(b3galt6)
NCC: 104942072(b3galt6)
MZE: 101485514(b3galt6)
OLA: 100049392(b3galt6)
XMA: 102230525(b3galt6)
PRET: 103464912(b3galt6)
NFU: 107385557(b3galt6)
CSEM: 103386136(b3galt6)
LCF: 108884066(b3galt6)
HCQ: 109522223(b3galt6)
BPEC: 110165823(b3galt6)
ELS: 105007424(b3galt6)
SFM: 108938192(b3galt6)
LCM: 102355255(B3GALT6)
CMK: 103187433(b3galt6)
CIN: 778996(b3galt6)
SPU: 753784
SKO: 100367674
DME: Dmel_CG8734(beta3GalTII)
DPO: Dpse_GA28758(Dpse_beta3galt6)
DER: Dere_GG10628(Dere_beta3galt6)
DPE: Dper_GL21178(Dper_beta3galt6)
DSE: Dsec_GM20673(Dsec_beta3galt6)
DSI: Dsimw501_GD27981(Dsim_GD27981)
DYA: Dyak_GE22868(Dyak_beta3galt6)
MDE: 101899820
AAG: 5568811
AME: 102655877
BIM: 100740262
BTER: 100644667
SOC: 105194992
AEC: 105155005
ACEP: 105626882
PBAR: 105426350
HST: 105186112
CFO: 105255994
LHU: 105669725
PGC: 109857902
NVI: 100680242
TCA: 656431
DPA: 109534754
NVL: 108563522
BMOR: 101740645
PMAC: 106712341
PRAP: 111001912
PXY: 105386738
DNX: 107164501
ZNE: 110831323
FCD: 110850766
CEL: CELE_Y110A2AL.14(sqv-2)
CBR: CBG19617(Cbr-sqv-2)
BMY: Bm1_42600
CRG: 105340554
MYI: 110450118
OBI: 106882295
LAK: 106161537
HMG: 100208936
CIT: 102607538
PPP: 112274831
CRE: CHLREDRAFT_21670(GTR17)
 » show all
Taxonomy
Reference
1  [PMID:3924029]
  Authors
Robinson JA, Robinson HC.
  Title
Initiation of chondroitin sulphate synthesis by beta-D-galactosides. Substrates for galactosyltransferase II.
  Journal
Biochem. J. 227 (1985) 805-14.
Reference
2  [PMID:1150655]
  Authors
Schwartz NB, Roden L.
  Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
  Journal
J. Biol. Chem. 250 (1975) 5200-7.
Reference
3  [PMID:11551958]
  Authors
Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD.
  Title
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).
  Journal
J. Biol. Chem. 276 (2001) 48189-95.
  Sequence
[hsa:126792] [mmu:117592]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.134
IUBMB Enzyme Nomenclature: 2.4.1.134
ExPASy - ENZYME nomenclature database: 2.4.1.134
BRENDA, the Enzyme Database: 2.4.1.134
CAS: 56626-21-2 56626-19-8

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