KEGG   ENZYME: 2.4.1.143Help
Entry
EC 2.4.1.143                Enzyme                                 

Name
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase II;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II;
acetylglucosaminyltransferase II;
uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase;
UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase;
alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase;
GnTII
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [RN:R07258]
Reaction(KEGG)
R07258;
(other) R04653 R05985(G)
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
6-(alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C15543]
Product
UDP [CPD:C00015];
6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C04944]
Comment
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor. Note that this enzyme acts after N-acetylglucosaminyltransferase I but before N-acetylglucosaminyltransferases III, IV, V and VI (click here for diagram).
History
EC 2.4.1.143 created 1984, modified 2001 (EC 2.4.1.51 created 1972, part incorporated 1984)
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways
Orthology
K00736  
alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Genes
HSA: 
4247(MGAT2)
PTR: 
740608(MGAT2)
PPS: 
100985211(MGAT2)
GGO: 
101130348(MGAT2)
PON: 
100460559(MGAT2)
NLE: 
100596086(MGAT2)
MCF: 
CJC: 
100403225(MGAT2)
MMU: 
217664(Mgat2)
RNO: 
94273(Mgat2)
CGE: 
100753385(Mgat2)
NGI: 
103731525(Mgat2)
HGL: 
101707621(Mgat2)
OCU: 
100348676(MGAT2)
TUP: 
102472350(MGAT2)
CFA: 
480312(MGAT2)
AML: 
100469937(MGAT2)
UMR: 
103666304(MGAT2)
FCA: 
101092119(MGAT2)
PTG: 
102949276(MGAT2)
BTA: 
101906103(MGAT2)
BOM: 
102282541(MGAT2)
PHD: 
102331940(MGAT2)
CHX: 
102188772(MGAT2)
OAS: 
101122525(MGAT2)
SSC: 
100151745(MGAT2)
CFR: 
102518813(MGAT2)
BACU: 
103017062(MGAT2)
LVE: 
103084076(MGAT2)
ECB: 
100065740(MGAT2)
MYB: 
102251136(MGAT2)
MYD: 
102755530(MGAT2)
PALE: 
102884447(MGAT2)
MDO: 
100023862(MGAT2)
SHR: 
100927464(MGAT2)
OAA: 
100084500(MGAT2)
GGA: 
428925(MGAT2)
MGP: 
FAB: 
101807768(MGAT2)
PHI: 
102104535(MGAT2)
FPG: 
101913920(MGAT2)
FCH: 
102059974(MGAT2)
CLV: 
102088921(MGAT2)
PSS: 
102448885(MGAT2)
CMY: 
102939955(MGAT2)
PBI: 
103052483(MGAT2)
XLA: 
414590(mgat2) 444674
XTR: 
448439(mgat2)
DRE: 
100000478(mgat2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
726476(Mgat2)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG23158(Cbr-gly-20)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
PVU: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0014s16520g(POPTRDRAFT_896156)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0798100-00(Os02g0798100)
OBR: 
BDI: 
SBI: 
SORBI_04g036090(SORBIDRAFT_04g036090)
ZMA: 
SITA: 
PDA: 
ATR: 
s00047p00072890(AMTR_s00047p00072890)
SMO: 
PPP: 
GSL: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:2952644]
  Authors
Bendiak B, Schachter H.
  Title
Control of glycoprotein synthesis. Purification of UDP-N-acetylglucosamine:alpha-D-mannoside beta 1-2 N-acetylglucosaminyltransferase II from rat liver.
  Journal
J. Biol. Chem. 262 (1987) 5775-83.
Reference
2  [PMID:6445358]
  Authors
Harpaz N, Schachter H.
  Title
Control of glycoprotein synthesis. Bovine colostrum UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I. Separation from UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase II, partial purification, and substrate specificity.
  Journal
J. Biol. Chem. 255 (1980) 4885-93.
Reference
3  [PMID:6452163]
  Authors
Mendicino J, Chandrasekaran EV, Anumula KR, Davila M.
  Title
Isolation and properties of alpha-D-mannose:beta-1,2-N-acetylglucosaminyltransferase from trachea mucosa.
  Journal
Biochemistry. 20 (1981) 967-76.
Reference
4  [PMID:6457827]
  Authors
Oppenheimer CL, Eckhardt AE, Hill RL.
  Title
The nonidentity of porcine N-acetylglucosaminyltransferases I and II.
  Journal
J. Biol. Chem. 256 (1981) 11477-82.
Reference
5  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods. Enzymol. 98 (1983) 98-134.
Reference
6  [PMID:2952645]
  Authors
Bendiak B, Schachter H
  Title
Control of glycoprotein synthesis. Kinetic mechanism, substrate specificity, and  inhibition characteristics of UDP-N-acetylglucosamine:alpha-D-mannoside beta 1-2  N-acetylglucosaminyltransferase II from rat liver.
  Journal
J. Biol. Chem. 262 (1987) 5784-90.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
105913-04-0

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