KEGG   ENZYME: 2.4.1.144Help
Entry
EC 2.4.1.144                Enzyme                                 
Name
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase III;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III;
uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III;
beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase;
GnTIII
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R [RN:R07259]
Reaction(KEGG)
R07259;
(other) R05986(G)
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-mannosyl-R [CPD:C04942]
Product
UDP [CPD:C00015];
4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R [CPD:C15544]
Comment
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor (click here for diagram). The action of this enzyme probably prevents further attachment of N-acetylglucosamine residues to the growing carbohydrate chain.
Pathway
N-Glycan biosynthesis
Metabolic pathways
Orthology
K00737  
beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Genes
HSA: 
4248(MGAT3)
PTR: 
470218(MGAT3)
PPS: 
100986687(MGAT3)
GGO: 
101140166(MGAT3)
PON: 
100461728(MGAT3)
MCC: 
703643(MGAT3)
MMU: 
17309(Mgat3)
RNO: 
29582(Mgat3)
CFA: 
481244(MGAT3)
AML: 
FCA: 
101096819(MGAT3)
BTA: 
520087(MGAT3)
ECB: 
100055333(MGAT3)
MDO: 
100012345
SHR: 
100917350(MGAT3)
OAA: 
100090777(MGAT3)
GGA: 
418013(MGAT3)
MGP: 
100550573
TGU: 
100226352(MGAT3)
ACS: 
100564985
XTR: 
100492491(mgat3)
DRE: 
553676(mgat3) 570828
TRU: 
101062954
OLA: 
101173368
DME: 
Dmel_CG31849
DPO: 
Dpse_GA16523
DAN: 
Dana_GF15645
DER: 
Dere_GG10226
DPE: 
Dper_GL24769
DSE: 
Dsec_GM25823
DSI: 
Dsim_GD22083
DWI: 
Dwil_GK23725
DYA: 
Dyak_GE11886
DGR: 
Dgri_GH10344
DMO: 
Dmoj_GI21171
DVI: 
Dvir_GJ10972
AGA: 
AgaP_AGAP008132
AAG: 
AaeL_AAEL005535 AaeL_AAEL005683
CQU: 
CpipJ_CPIJ000919
AME: 
100578875
PHU: 
Phum_PHUM609430
ISC: 
IscW_ISCW021719
NVE: 
NEMVE_v1g217354
ATH: 
AT1G12990 AT1G67880 AT2G13290 AT3G01620 AT3G27540 AT5G14480
ALY: 
ARALYDRAFT_477353 ARALYDRAFT_480301 ARALYDRAFT_484544 ARALYDRAFT_488289 ARALYDRAFT_888651 ARALYDRAFT_894549
GMX: 
100778832 100787062 100804627 100807933 100816069
MTR: 
MTR_3g096150
CSV: 
101216914 101220682 101222690 101223805
RCU: 
RCOM_0793870 RCOM_1064760 RCOM_1074580
POP: 
POPTR_1085621 POPTR_230496 POPTR_578921
VVI: 
100254142 100254389 100259362
OSA: 
4329853 4336162 4352772
DOSA: 
Os02t0594900-01(Os02g0594900) Os04t0477500-01(Os04g0477500) Os12t0611900-01(Os12g0611900)
BDI: 
100828716 100829334 100843118
SBI: 
SORBI_04g024790(SORBIDRAFT_04g024790) SORBI_06g020110(SORBIDRAFT_06g020110) SORBI_08g021190(SORBIDRAFT_08g021190)
ZMA: 
100194350 100282445 100282765 100383596 100501240
SMO: 
SELMODRAFT_109556(GT17A2) SELMODRAFT_403018(GT17A3) SELMODRAFT_409063(GT17A1)
PPP: 
PHYPADRAFT_116976 PHYPADRAFT_123467
OLU: 
OSTLU_18822
NCR: 
NCU07455
SMP: 
SMAC_05190
PAN: 
PODANSg5679
TTT: 
THITE_2113936
MTM: 
MYCTH_2295857
MGR: 
MGG_04516
FGR: 
FG05624.1
NHE: 
NECHADRAFT_95451
SSL: 
SS1G_01418 SS1G_02625
BFU: 
BC1G_01140 BC1G_07943
AJE: 
HCAG_01215
ZTR: 
MYCGRDRAFT_15744
LBC: 
LACBIDRAFT_296226
MPR: 
MPER_04845 MPER_14526
SCM: 
SCHCODRAFT_69062
ENC: 
ECL_01461
ECLO: 
ENC_12120
EEC: 
EcWSU1_02766
MPC: 
Mar181_0482 Mar181_0486
BMU: 
Bmul_0967
BMJ: 
BMULJ_02297(mgaT)
BGD: 
bgla_1g04500
PNU: 
Pnuc_1802
PNE: 
Pnec_0274
BBA: 
Bd1672
BBAT: 
Bdt_1662
PSF: 
PSE_3293
RCE: 
RC1_4017
TMO: 
TMO_a0549
PGV: 
SL003B_4280
APM: 
HIMB5_00012700
BPB: 
bpr_I2522
SSG: 
Selsp_0401
SRI: 
SELR_26480
TPX: 
Turpa_2635
 » show all
Taxonomy
Reference
1  [PMID:6213618]
  Authors
Narasimhan S.
  Title
Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides.
  Journal
J. Biol. Chem. 257 (1982) 10235-42.
  Organism
Gallus gallus [GN:gga]
Reference
2  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods. Enzymol. 98 (1983) 98-134.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
83744-93-8
DBGET integrated database retrieval system