KEGG   ENZYME: 2.4.1.145Help
Entry
EC 2.4.1.145                Enzyme                                 

Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase IV;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV;
beta-acetylglucosaminyltransferase IV;
uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV;
alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase;
GnTIV
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [RN:R04662]
Reaction(KEGG)
R04662;
(other) R05987(G)
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C04880]
Product
UDP [CPD:C00015];
3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C04943]
Comment
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor (click here for diagram). The best acceptor for this enzyme is probably the same as that favoured by EC 2.4.1.144, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.
History
EC 2.4.1.145 created 1984, modified 2001 (EC 2.4.1.51 created 1972, part incorporated 1984)
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways
Orthology
K00738  
alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B
K13748  
alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase C
Genes
HSA: 
11282(MGAT4B) 11320(MGAT4A) 152586(MGAT4D) 25834(MGAT4C)
PTR: 
459434(MGAT4A) 461502(MGAT4D) 467085(MGAT4C) 471774(MGAT4B)
PPS: 
100981022(MGAT4B) 100992134(MGAT4C) 100994401(MGAT4D) 100996009(MGAT4A)
GGO: 
101141983 101143539(MGAT4A) 101148891(MGAT4B) 101151757(MGAT4C)
PON: 
100190826(MGAT4A) 100455323(MGAT4C) 100457326(MGAT4B) 100938596(MGAT4D)
NLE: 
100584226(MGAT4C) 100587238(MGAT4A) 100607570(MGAT4B) 105740065(MGAT4D)
MCC: 
700450(MGAT4C) 701630(MGAT4D) 705006(MGAT4B) 708094(MGAT4A)
MCF: 
101866133(MGAT4A) 101866242(MGAT4C) 102143163(MGAT4B) 102146807(MGAT4D)
CSAB: 
103236295(MGAT4D) 103238817(MGAT4C) 103241101(MGAT4A) 103245113(MGAT4B)
RRO: 
104654329(MGAT4D) 104655963(MGAT4C) 104661480(MGAT4A) 104676225(MGAT4B)
CJC: 
100391287(MGAT4B) 100398052(MGAT4A) 100413583(MGAT4C) 103791867(MGAT4D)
SBQ: 
101037371(MGAT4B) 101037806(MGAT4D) 101039237(MGAT4A) 101043109(MGAT4C)
MMU: 
103534(Mgat4b) 269181(Mgat4a) 67555(Mgat4d) 67569(Mgat4c)
RNO: 
299756(Mgat4c) 303100(Mgat4b) 304646(Mgat4d) 367252(Mgat4a)
CGE: 
100760589(Mgat4c) 100766200(Mgat4a) 100768637(Mgat4b) 100774333(Mgat4d)
NGI: 
103726602(Mgat4c) 103742396(Mgat4d) 103744157(Mgat4a) 103749373(Mgat4b)
HGL: 
101716811 101722510(Mgat4a) 101723043(Mgat4b) 101725010(Mgat4c) 101726304(Mgat4d)
OCU: 
100338722(MGAT4A) 100339976(MGAT4C) 100346059(MGAT4B) 100346813(MGAT4D)
TUP: 
102467784(MGAT4C) 102475912(MGAT4A) 102480932(MGAT4D) 102484580(MGAT4B)
CFA: 
102153780(MGAT4D) 474562(MGAT4A) 475418(MGAT4C) 481458(MGAT4B)
AML: 
100465193(MGAT4C) 100469508(MGAT4B) 100481251(MGAT4A) 105236214(MGAT4D)
UMR: 
103658076(MGAT4D) 103660061(MGAT4C) 103671181(MGAT4A) 103680013(MGAT4B)
FCA: 
101088153(MGAT4A) 101095945(MGAT4B) 101096077(MGAT4C) 102900578(MGAT4D)
PTG: 
102953882(MGAT4B) 102962178(MGAT4D) 102966537(MGAT4A) 102971513(MGAT4C)
BTA: 
101907024(MGAT4D) 282276(MGAT4A) 526256(MGAT4B) 539661(MGAT4C)
BOM: 
102269061(MGAT4C) 102281135(MGAT4B) 102281255(MGAT4D) 102286450(MGAT4A)
PHD: 
102316698(MGAT4B) 102325642(MGAT4C) 102337122(MGAT4D) 102340515(MGAT4A)
CHX: 
102168993 102169257(MGAT4C) 102173548(MGAT4B) 102177532(MGAT4A) 102191262(MGAT4D)
OAS: 
101105106(MGAT4D) 101108733(MGAT4C) 101108820(MGAT4A) 101119044(MGAT4B)
SSC: 
100512242(MGAT4D) 100521073(MGAT4B) 100524079(MGAT4A) 414851(MGAT4C)
CFR: 
102503643(MGAT4D) 102503714(MGAT4C) 102506006(MGAT4B) 102522357(MGAT4A)
BACU: 
103004161(MGAT4C) 103010086(MGAT4A) 103011292(MGAT4B) 103018629(MGAT4D)
LVE: 
103075784(MGAT4A) 103080459(MGAT4C) 103086020(MGAT4B)
ECB: 
100050964(MGAT4A) 100051064(MGAT4C) 100067257(MGAT4B) 102147352(MGAT4D)
MYB: 
102244266(MGAT4D) 102248905(MGAT4A) 102253362(MGAT4C) 102258316(MGAT4B)
MYD: 
102760456(MGAT4D) 102762292(MGAT4A) 102769462(MGAT4C) 102770440(MGAT4B)
PALE: 
102882602(MGAT4C) 102882798(MGAT4A) 102891025(MGAT4D) 102891973(MGAT4B)
LAV: 
MDO: 
100013784(MGAT4A) 100020942(MGAT4C) 100027218(MGAT4D) 100028175(MGAT4B)
SHR: 
OAA: 
100081053(MGAT4C) 100081934(MGAT4D) 100093525(MGAT4A)
GGA: 
395415(MGAT4C) 416285(MGAT4B) 418692(MGAT4A) 422448 427873(MGAT4C)
MGP: 
100538511(MGAT4A) 100541955(MGAT4C) 100542581(MGAT4D) 100543731(MGAT4B) 100550363
CJO: 
107307274(MGAT4A) 107311189(MGAT4C) 107313112(MGAT4D) 107320122(MGAT4B) 107324722
APLA: 
101791726(MGAT4C) 101798874(MGAT4D) 101799353 101803616(MGAT4A) 101804040(MGAT4B)
TGU: 
100218916(MGAT4A) 100220057(MGAT4D) 100224306(MGAT4B) 100228531(MGAT4C) 100232682
GFR: 
102034112(MGAT4C) 102039120(MGAT4B) 102039150(MGAT4D) 102042558(MGAT4A) 102043367
FAB: 
101806014(MGAT4A) 101807568(MGAT4D) 101809036(MGAT4C) 101815032 101820554(MGAT4B)
PHI: 
102101535(MGAT4D) 102102354(MGAT4A) 102103698 102109899(MGAT4B) 102110314(MGAT4C)
CCW: 
104686044(MGAT4A) 104689699(MGAT4B) 104692465 104697272(MGAT4D) 104698425(MGAT4C)
FPG: 
101913766(MGAT4D) 101914300(MGAT4C) 101916895(MGAT4B) 101916943 101918425(MGAT4A)
FCH: 
102045721(MGAT4C) 102049618 102052657(MGAT4D) 102053135(MGAT4A) 102055497(MGAT4B)
CLV: 
102084023(MGAT4A) 102087504(MGAT4D) 102088784(MGAT4C) 102089679 102090946(MGAT4B)
AAM: 
106485644 106488510(MGAT4C) 106491859(MGAT4D) 106493437(MGAT4B) 106493958(MGAT4A)
ASN: 
102374657(MGAT4C) 102375548(MGAT4A) 102376706 102378177 102382074(MGAT4B) 102384961(MGAT4D)
AMJ: 
102560247 102563452 102564947(MGAT4A) 102568458(MGAT4B) 102570305(MGAT4D) 102575494(MGAT4C)
PSS: 
CMY: 
ACS: 
100552582(mgat4a) 100556708 100561638(mgat4c) 100562892 100565033(mgat4b) 100567983(mgat4d)
PBI: 
103052083(MGAT4C) 103056391(MGAT4D) 103056592 103058530(MGAT4A) 103060647(MGAT4B) 103067082
GJA: 
107107839 107110310(MGAT4B) 107110414(MGAT4A) 107110771(MGAT4D) 107111720 107123105(MGAT4C)
XLA: 
443870(mgat4b.L) 734354(mgat4a.S)
XTR: 
100124983(mgat4b) 100145594(mgat4a) 100486336(mgat4c) 100489322(mgat4b)
DRE: 
100333333(mgat4c) 431727(mgat4b) 492796(fb74e05) 563038(mgat4a)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102346343(MGAT4C) 102347820(MGAT4C) 102348296(MGAT4A) 102361763 102366175 102366272(MGAT4B)
CMK: 
103175065 103177135(mgat4a) 103179072 103181292(mgat4d) 103185333(mgat4c) 103188228(mgat4b)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD12602(Dsim_GD12602) Dsimw501_GD14502(Dsim_GD14502)
DWI: 
DYA: 
Dyak_GE20004(dyak_GLEANR_3855) Dyak_GE22027(dyak_GLEANR_5739)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
API: 
PHU: 
DPX: 
ISC: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
HMG: 
TAD: 
MBR: 
SRE: 
SMIN: 
v1.2.033022.t1(symbB.v1.2.033022.t1)
 » show all
Taxonomy
Reference
1  [PMID:6222042]
  Authors
Gleeson PA, Schachter H.
  Title
Control of glycoprotein synthesis.
  Journal
J. Biol. Chem. 258 (1983) 6162-73.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
86498-16-0

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