KEGG   ENZYME: 2.4.1.146Help
Entry
EC 2.4.1.146                Enzyme                                 

Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II;
uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating);
elongation 3beta-GalNAc-transferase;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to beta-D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->3)-[N-acetyl-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-[N-acetyl-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R [RN:R04636 R05901]
Reaction(KEGG)
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->3)-[N-acetyl-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R
Comment
cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase).
History
EC 2.4.1.146 created 1984
Orthology
K07970  
beta-1,3-N-acetylglucosaminyltransferase 3
Genes
HSA: 
10331(B3GNT3)
PTR: 
455847(B3GNT3)
PPS: 
100982986(B3GNT3)
GGO: 
101151557(B3GNT3)
PON: 
100433243(B3GNT3)
NLE: 
100596245(B3GNT3)
MCC: 
719221(B3GNT3)
MCF: 
102134304(B3GNT3)
CSAB: 
103234153(B3GNT3)
RRO: 
104660961(B3GNT3)
RBB: 
108534279(B3GNT3)
CJC: 
100404385(B3GNT3)
SBQ: 
101033879(B3GNT3)
MMU: 
72297(B3gnt3)
RNO: 
290638(B3gnt3)
CGE: 
100773213(B3gnt3)
NGI: 
103726889(B3gnt3)
HGL: 
101713138(B3gnt3)
CCAN: 
109698339(B3gnt3)
TUP: 
CFA: 
484831(B3GNT3)
AML: 
100473756(B3GNT3)
UMR: 
103675168(B3GNT3)
FCA: 
101092089(B3GNT3)
PTG: 
102965987(B3GNT3)
AJU: 
106969093(B3GNT3)
BTA: 
784997(B3GNT3)
BOM: 
102281061(B3GNT3)
BIU: 
109560822(B3GNT3)
CHX: 
102171777(B3GNT3)
OAS: 
101113066(B3GNT3)
SSC: 
100518473(B3GNT3)
CFR: 
102512477(B3GNT3)
CDK: 
105101856(B3GNT3)
BACU: 
103012961(B3GNT3)
LVE: 
103080965(B3GNT3)
ECB: 
100146466(B3GNT3)
EPZ: 
103542315(B3GNT3)
EAI: 
106830835(B3GNT3)
MYB: 
102254606(B3GNT3)
MYD: 
102767713(B3GNT3)
HAI: 
109382386(B3GNT3)
RSS: 
109450104(B3GNT3)
PALE: 
102882932(B3GNT3)
LAV: 
100673587(B3GNT3)
MDO: 
100010637(B3GNT3)
SHR: 
100920625(B3GNT3)
OAA: 
MGP: 
100549756(B3GNT3)
APLA: 
101789872(B3GNT3)
ACYG: 
106048207(B3GNT3)
FPG: 
106112886(B3GNT3)
FCH: 
102054592(B3GNT3)
CLV: 
102095902(B3GNT3)
AAM: 
ASN: 
102373956(B3GNT3)
AMJ: 
106737906(B3GNT3)
PSS: 
102443521(B3GNT3)
CMY: 
102944348(B3GNT3)
CPIC: 
101936651(B3GNT3)
PVT: 
110072506(B3GNT3)
PBI: 
103061136(B3GNT3)
GJA: 
107120629(B3GNT3)
XLA: 
XTR: 
NPR: 
DRE: 
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
101072648(b3gnt3)
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
109519123(b3gnt3)
BPEC: 
SASA: 
ELS: 
SFM: 
108930515(b3gnt3)
LCM: 
102345207(B3GNT3)
CMK: 
103181970(b3gnt3)
 » show all
Taxonomy
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr. Res. 120 (1983) 3-16.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
87927-99-9

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