| Entry |
|
|---|
| Name |
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase;
Lewis-negative alpha-3-fucosyltransferase;
plasma alpha-3-fucosyltransferase;
guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase;
galactoside 3-fucosyltransferase;
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
3-alpha-L-fucosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
GDP-beta-L-fucose:(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
3-alpha-L-fucosyltransferase |
|---|
| Reaction(IUBMB) |
GDP-beta-L-fucose +
(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP +
(1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-
glucosaminyl-R [RN:R03519] |
|---|
| Reaction(KEGG) |
R03519 > R05904(G) R06025(G) R06038(G) R06039(G);
(other) R06075(G) R06076(G) R06095(G)
 |
|---|
| Substrate |
GDP-beta-L-fucose [CPD:C00325];
(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R |
|---|
| Product |
GDP [CPD:C00035];
(1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-
glucosaminyl-R |
|---|
| Comment |
Normally acts on a glycoconjugate where R (see reaction) is a
glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an
N-acetylglucosamine that carries a galactosyl group on O-4, unlike
EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide
4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an
N-acetylglucosamine that carries a galactosyl group on O-3. |
|---|
| Pathway |
PATH: ec00601 Glycosphingolipid biosynthesis - lacto and neolacto
series
PATH: ec00603 Glycosphingolipid biosynthesis - globo series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K03663 4-galactosyl-N-acetylglucosaminide
3-alpha-L-fucosyltransferase |
|---|
| Genes |
HSA: 10690(FUT9)
PTR: 449500(FUT9)
MMU: 14348(Fut9)
RNO: 84597(Fut9)
CFA: 449027(FUT9)
BTA: 282853(FUT9)
SSC: 100155421
ECB: 100071396
MDO: 100020278
OAA: 100075626
GGA: 771133(FUT9)
XTR: 548391(fut9)
DRE: 564968 796410
 |
|---|
| Structures |
PDB: 2NZW 2NZX 2NZY |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7295318]
Johnson PH, Yates AD, Watkins WM.
Human salivary fucosyltransferases : evidence for two distinct
alpha-3-L-fucosyltransferase activities one or which is associated
with the Lewis blood group Le gene.
Biochem. Biophys. Res. Commun. 100 (1981) 1611-8.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:6366476]
Schachter H, Narasimhan S, Gleeson P, Vella G.
Glycosyltransferases involved in elongation of N-glycosidically
linked oligosaccharides of the complex or N-acetyllactosamine type.
Methods. Enzymol. 98 (1983) 98-134. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:12676935]
Ma B, Wang G, Palcic MM, Hazes B, Taylor DE.
C-terminal amino acids of Helicobacter pylori alpha1,3/4
fucosyltransferases determine type I and type II transfer.
J. Biol. Chem. 278 (2003) 21893-900.
Homo sapiens [GN:hsa], Helicobacter pylori |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.152
IUBMB Enzyme Nomenclature: 2.4.1.152
ExPASy - ENZYME nomenclature database: 2.4.1.152
BRENDA, the Enzyme Database: 2.4.1.152
CAS: 39279-34-0 |
|---|
