KEGG   ENZYME: 2.4.1.159Help
Entry
EC 2.4.1.159                Enzyme                                 

Name
flavonol-3-O-glucoside L-rhamnosyltransferase;
uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase;
UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase;
UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-beta-L-rhamnose:flavonol-3-O-beta-D-glucoside 6''-O-L-rhamnosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-beta-L-rhamnose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] [RN:R03880]
Reaction(KEGG)
Substrate
UDP-beta-L-rhamnose [CPD:C02199];
flavonol 3-O-beta-D-glucoside [CPD:C03946]
Product
UDP [CPD:C00015];
flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] [CPD:C04194]
Comment
A configuration-inverting rhamnosyltransferase that converts flavonol 3-O-glucosides to 3-O-rutinosides. Also acts, more slowly, on rutin, quercetin 3-O-galactoside and flavonol 3-O-rhamnosides.
History
EC 2.4.1.159 created 1986, modified 2015
Pathway
ec00944  Flavone and flavonol biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Kleinehollenhorst, G., Behrens, H., Pegels, G., Srunk, N. and Wiermann, R.
  Title
Formation of flavonol 3-O-diglycosides and flavonol 3-O-triglycosides by enzyme extracts from anthers of Tulipa cv apeldoorn - characterization and activity of 3 different O-glycosyltransferases during anther development.
  Journal
Z. Natursforsch. C: Biosci. 37 (1982) 587-599.
Reference
2  [PMID:12900416]
  Authors
Jones P, Messner B, Nakajima J, Schaffner AR, Saito K.
  Title
UGT73C6 and UGT78D1, glycosyltransferases involved in flavonol glycoside biosynthesis in Arabidopsis thaliana.
  Journal
J. Biol. Chem. 278 (2003) 43910-8.
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.159
IUBMB Enzyme Nomenclature: 2.4.1.159
ExPASy - ENZYME nomenclature database: 2.4.1.159
BRENDA, the Enzyme Database: 2.4.1.159
CAS: 83380-89-6

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