KEGG   ENZYME: 2.4.1.175Help
Entry
EC 2.4.1.175                Enzyme                                 
Name
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase;
N-acetylgalactosaminyltransferase II;
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase;
chondroitin synthase;
glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II;
UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan [RN:R04603]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
Comment
Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase (EC 2.4.1.226, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli.
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Metabolic pathways
Orthology
K00746  
chondroitin sulfate N-acetylgalactosaminyltransferase 1/2
K00747  
chondroitin polymerizing factor
K13499  
chondroitin sulfate synthase
K13500  
chondroitin synthase
Genes
HSA: 
22856(CHSY1) 337876(CHSY3) 55454(CSGALNACT2) 55790(CSGALNACT1) 79586(CHPF)
PTR: 
450416(CSGALNACT2) 464030(CSGALNACT1) 467777(CHSY1) 471623(CHSY3) 743513(CHPF)
PPS: 
100968775(CHSY1) 100971582(CHPF) 100972801 100987599(CSGALNACT1) 100994377(CSGALNACT2)
GGO: 
101126045(CHSY3) 101136357(CHSY1) 101144411(CHPF) 101151962(CSGALNACT2) 101154228(CSGALNACT1)
PON: 
100172853(CSGALNACT2) 100442293(CSGALNACT1) 100449809(CHSY1) 100455730(CHPF)
MCC: 
100423555(CHSY3) 694481(CHSY1) 703703(CSGALNACT2) 703860(CHPF) 704901(CSGALNACT1)
MMU: 
234356(Csgalnact1) 269941(Chsy1) 74241(Chpf) 78752(Csgalnact2) 78923(Chsy3)
RNO: 
291577(Chsy3) 292999(Chsy1) 297554(Csgalnact2) 306375(Csgalnact1) 316533(Chpf)
CFA: 
481492(CHSY3) 482831(CSGALNACT1) 486786(CSGALNACT2) 488539(OBSL1) 488704(CHSY1)
AML: 
100466495(CHSY1) 100468746(CSGALNACT1) 100484507(CHSY3) 100484755(CSGALNACT2)
FCA: 
101083179(CHSY1) 101092580(CHSY3) 101096311(CSGALNACT1) 101097752(CHPF) 101100841(CSGALNACT2)
BTA: 
281690(CHSY1) 509328(CSGALNACT2) 528057(CSGALNACT1) 528149(CHSY3) 540002(CHPF)
SSC: 
100157878(CSGALNACT2) 100517735(CSGALNACT1) 100518720(CHSY3) 100520288(CHSY1) 100623047
ECB: 
100050200(CSGALNACT2) 100052192(CSGALNACT1) 100057477(CHSY1) 100059511 100072984(CHSY3)
MDO: 
100010621(CHPF) 100012272(CSGALNACT2) 100020781(CHSY1) 100030310(CSGALNACT1)
SHR: 
100913326(CHPF) 100923374(CHSY1) 100925396(CSGALNACT1) 100925905(CSGALNACT2)
OAA: 
100076249(CSGALNACT2) 100078026(CSGALNACT1) 100680815
GGA: 
415521(CHSY1) 415598(CHSY3) 422488(CSGALNACT1) 423632(CSGALNACT2) 769112(CHPF)
MGP: 
100538576(CSGALNACT1) 100540185(CHSY1) 100550036 100550089(CSGALNACT2) 100550164(CHSY3)
TGU: 
100222602(CHSY1) 100223510(CSGALNACT1) 100223757(CHSY3) 100225582(CHPF) 100231851(CSGALNACT2)
ACS: 
100554248(chsy1) 100556433(chsy3) 100558813(csgalnact2) 100560221 100560783(csgalnact1)
XTR: 
100036707(chsy1) 100124741(csgalnact2) 100379780(chpf) 100494038(chsy3) 100497098(csgalnact1)
DRE: 
100331155(chpf) 324407(chsy1) 560826 793671
TRU: 
101061544 101079035 101079052 101079135
OLA: 
101155099 101155793 101157180 101162617
BFO: 
BRAFLDRAFT_123885 BRAFLDRAFT_124328
CIN: 
100177392 100177589
SPU: 
579124 579341(CHSY1)
DME: 
Dmel_CG12913 Dmel_CG43313 Dmel_CG9220
DPO: 
Dpse_GA11904 Dpse_GA18127 Dpse_GA22578
DAN: 
Dana_GF12786 Dana_GF20873 Dana_GF22250
DER: 
Dere_GG19389 Dere_GG19525 Dere_GG24153
DPE: 
Dper_GL11584 Dper_GL16444 Dper_GL16491
DSE: 
Dsec_GM11517 Dsec_GM21196 Dsec_GM22544
DSI: 
Dsim_GD10724 Dsim_GD15794 Dsim_GD24523
DWI: 
Dwil_GK17784 Dwil_GK25019 Dwil_GK25624
DYA: 
Dyak_GE16036 Dyak_GE16179 Dyak_GE19348
DGR: 
Dgri_GH11859 Dgri_GH21775 Dgri_GH24548
DMO: 
Dmoj_GI15636 Dmoj_GI16262 Dmoj_GI19322
DVI: 
Dvir_GJ16903 Dvir_GJ19224 Dvir_GJ22200
AGA: 
AgaP_AGAP001010 AgaP_AGAP001050 AgaP_AGAP007720
AAG: 
AaeL_AAEL006466 AaeL_AAEL010569 AaeL_AAEL013572
CQU: 
CpipJ_CPIJ015759 CpipJ_CPIJ018456 CpipJ_CPIJ019283
AME: 
413549
TCA: 
656073 656110
API: 
100166045
PHU: 
Phum_PHUM115050 Phum_PHUM539580 Phum_PHUM567440
ISC: 
IscW_ISCW013435
CEL: 
CELE_PAR2.4(mig-22) CELE_T24D1.1(sqv-5)
CBR: 
CBG03828(Cbr-sqv-5) CBG06915(Cbr-mig-22)
BMY: 
Bm1_19700 Bm1_44390
TSP: 
Tsp_00078 Tsp_10489
NVE: 
NEMVE_v1g177601 NEMVE_v1g240106
HMG: 
100199409 100201765
AQU: 
100635011
PMU: 
PM0775
FBL: 
Fbal_0446
CPH: 
Cpha266_2341
 » show all
Taxonomy
Reference
1  [PMID:3922754]
  Authors
Rohrmann K, Niemann R, Buddecke E.
  Title
Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate.
  Journal
Eur. J. Biochem. 148 (1985) 463-9.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:11514575]
  Authors
Kitagawa H, Uyama T, Sugahara K.
  Title
Molecular cloning and expression of a human chondroitin synthase.
  Journal
J. Biol. Chem. 276 (2001) 38721-6.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:10818104]
  Authors
DeAngelis PL, Padgett-McCue AJ.
  Title
Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.
  Journal
J. Biol. Chem. 275 (2000) 24124-9.
  Organism
Pasteurella multocida [GN:pmu]
Reference
4  [PMID:11943778]
  Authors
Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K.
  Title
Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.
  Journal
J. Biol. Chem. 277 (2002) 21567-75.
  Organism
Escherichia coli [GN:eco]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
96189-40-1
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