KEGG   ENZYME: 2.4.1.179Help
Entry
EC 2.4.1.179                Enzyme                                 

Name
lactosylceramide beta-1,3-galactosyltransferase;
uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase;
UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase;
UDP-galactose:D-galactosyl-(1->4)-beta-D-glucosyl-R 3-beta-galactosyltransferase;
UDP-alpha-D-galactose:D-galactosyl-(1->4)-beta-D-glucosyl-R 3-beta-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-D-glucosyl-R 3-beta-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-R = UDP + beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R [RN:R04431]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-R [CPD:C04247]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R [CPD:C04775]
Comment
R may be an oligosaccharide or a glycolipid; lactose can also act as acceptor, but more slowly. Involved in the elongation of oligosaccharide chains, especially in glycolipids.
History
EC 2.4.1.179 created 1989
Pathway
Glycosphingolipid biosynthesis - globo and isoglobo series
Reference
1  [PMID:3129295]
  Authors
Bailly P, Piller F, Cartron JP.
  Title
Characterization and specific assay for a galactoside beta-3-galactosyltransferase of human kidney.
  Journal
Eur. J. Biochem. 173 (1988) 417-22.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
106769-64-6

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