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Entry
EC 2.4.1.231                Enzyme                                 

Name
alpha,alpha-trehalose phosphorylase (configuration-retaining);
trehalose phosphorylase[ambiguous]
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase
Reaction(IUBMB)
alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate [RN:R07265]
Reaction(KEGG)
Substrate
alpha,alpha-trehalose [CPD:C01083];
phosphate [CPD:C00009]
Product
alpha-D-glucose [CPD:C00267];
alpha-D-glucose 1-phosphate [CPD:C00103]
Comment
Unlike EC 2.4.1.64, alpha,alpha-trehalose phosphorylase, this enzyme retains its anomeric configuration. Vanadate is a strong competitive inhibitor of this reversible reaction.
History
EC 2.4.1.231 created 2003
Orthology
K22248  alpha,alpha-trehalose phosphorylase (configuration-retaining)
Genes
NCR: NCU09559(ccg-9)
NTE: NEUTE1DRAFT131038(NEUTE1DRAFT_131038)
SMP: SMAC_05699(putative ccg9)
PAN: PODANSg1171
TTT: THITE_2117861
MTM: MYCTH_2308065
CTHR: CTHT_0019540
MGR: MGG_00195
TMN: UCRPA7_8792
FGR: FGSG_04456
MAW: MAC_09793
MAJ: MAA_09323
MBE: MBM_07660
ANG: ANI_1_1116164(An18g01640) ANI_1_2720024(An02g07770)
CIM: CIMG_11719(CIMG06287)
ABE: ARB_07071
TVE: TRV_05695
PTE: PTT_04389
CNE: CNG04480
CNB: CNBG0220
ABP: AGABI1DRAFT111552(AGABI1DRAFT_111552)
ABV: AGABI2DRAFT190782(AGABI2DRAFT_190782)
 » show all
Taxonomy
Reference
1  [PMID:11931662]
  Authors
Eis C, Nidetzky B.
  Title
Substrate-binding recognition and specificity of trehalose phosphorylase from Schizophyllum commune examined in steady-state kinetic studies with deoxy and deoxyfluoro substrate analogues and inhibitors.
  Journal
Biochem. J. 363 (2002) 335-40.
Reference
2  [PMID:11389683]
  Authors
Eis C, Watkins M, Prohaska T, Nidetzky B.
  Title
Fungal trehalose phosphorylase: kinetic mechanism, pH-dependence of the reaction and some structural properties of the enzyme from Schizophyllum commune.
  Journal
Biochem. J. 356 (2001) 757-67.
Reference
3  [PMID:11736665]
  Authors
Nidetzky B, Eis C.
  Title
Alpha-retaining glucosyl transfer catalysed by trehalose phosphorylase from Schizophyllum commune: mechanistic evidence obtained from steady-state kinetic studies with substrate analogues and inhibitors.
  Journal
Biochem. J. 360 (2001) 727-36.
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.231
IUBMB Enzyme Nomenclature: 2.4.1.231
ExPASy - ENZYME nomenclature database: 2.4.1.231
BRENDA, the Enzyme Database: 2.4.1.231

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