KEGG   ENZYME: 2.4.1.232
Entry
EC 2.4.1.232                Enzyme                                 
Name
initiation-specific alpha-1,6-mannosyltransferase;
alpha-1,6-mannosyltransferase;
GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase;
GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase;
glycolipid 6-alpha-mannosyltransferase;
GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase
Reaction(IUBMB)
Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage
Reaction(KEGG)
(other) R06986(G) R08599(G)
Comment
Requires Mn2+. In Saccharomyces cerevisiae, this enzyme catalyses an essential step in the outer chain elongation of N-linked oligosaccharides. Man8GlcNAc and Man9GlcNAc are equally good substrates.
History
EC 2.4.1.232 created 2004
Pathway
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K05528  alpha 1,6-mannosyltransferase
K05529  mannan polymerase complexes MNN9 subunit
Genes
BFO118411725
HROHELRODRAFT_153976
PCAN112561057
HRF124150828
HRJ124260835
CRG105320143 117685401
CANU128184057 128184059 128184061
MMER123534147 123555091 123555664 123555901 123555902 123556100
RPHI132716781 132752629
OBI106868997 106869556
LAK106162184 106173809
QSU111992006
MNGMNEG_9768
CMECYME_CMT636C
GSLGasu_17110 Gasu_59940
SCEYGL038C(OCH1) YPL050C(MNN9)
SEUBDI49_1929 DI49_5408
SPAOSPAR_G01980 SPAR_P02160
AGOAGOS_AFR465C AGOS_AGL259C
ERCEcym_1409 Ecym_2550
KLAKLLA0_C04125g KLLA0_E12849g KLLA0_F22220g
KMXKLMA_10184(och1) KLMA_40267(OCH1) KLMA_70378(MNN9)
LTHKLTH0E11616g KLTH0H09064g
VPOKpol_1026p11 Kpol_1031p78
ZROZYRO0F08492g ZYRO0G09284g
CGRCAGL0A01738g CAGL0L12804g
NCSNCAS_0A01880(NCAS0A01880) NCAS_0B02440(NCAS0B02440) NCAS_0C02330(NCAS0C02330)
NDINDAI_0C05250(NDAI0C05250) NDAI_0D03810(NDAI0D03810) NDAI_0E03020(NDAI0E03020)
TPFTPHA_0F00500(TPHA0F00500) TPHA_0K01810(TPHA0K01810) TPHA_0L01370(TPHA0L01370)
TBLTBLA_0B00380(TBLA0B00380) TBLA_0C04290(TBLA0C04290) TBLA_0H03340(TBLA0H03340)
TGBHG536_0D04830 HG536_0H01410
TDLTDEL_0B01370(TDEL0B01370) TDEL_0F02760(TDEL0F02760)
KAFKAFR_0F03660(KAFR0F03660) KAFR_0H01390(KAFR0H01390)
KNGKNAG_0A02150(KNAG0A02150) KNAG_0A03990(KNAG0A03990) KNAG_0D03770(KNAG0D03770)
ZMKHG535_0B05480 HG535_0C01350
PPAPAS_chr1-3_0251 PAS_chr4_0103
DHADEHA2C13508g DEHA2D15972g
PICPICST_56149 PICST_76016(OCH1)
PGUPGUG_00592 PGUG_05622
SPAASPAPADRAFT_143242 SPAPADRAFT_143660 SPAPADRAFT_143760 SPAPADRAFT_155280(OCH1) SPAPADRAFT_49565 SPAPADRAFT_52588 SPAPADRAFT_53501 SPAPADRAFT_59962 SPAPADRAFT_61486 SPAPADRAFT_62310 SPAPADRAFT_62316 SPAPADRAFT_62531 SPAPADRAFT_72461
LELPVL30_003578(OCH1) PVL30_003659(MNN9)
CALCAALFM_C306020WA(MNN9) CAALFM_C306090CA(OCH1)
CTPCTRG_02254 CTRG_02261
COTCORT_0C02360 CORT_0C04350
CDUCD36_85950(MNN9) CD36_86020
CTENCANTEDRAFT_129353 CANTEDRAFT_99095
YLIYALI0B12518g
CLUCLUG_01658 CLUG_02025
CLUSA9F13_02g02673 A9F13_13g01012
CAURCJI96_0000373 CJI96_0002796
SLBAWJ20_134(HOC1) AWJ20_191(MNN9)
PKZC5L36_0A08300 C5L36_0B02277 C5L36_0B07470 C5L36_0B08630 C5L36_0C02090
BNNFOA43_003835(MNN9) FOA43_004150
BBRXBRETT_000545 BRETT_002798 BRETT_003985
OPAHPODL_01382 HPODL_01489 HPODL_01625 HPODL_02407 HPODL_02408 HPODL_03209 HPODL_04510 HPODL_04840
SLUDSCDLUD_001544 SCDLUD_001970
NCRNCU00609(och-1) NCU02635
NTENEUTE1DRAFT126859(NEUTE1DRAFT_126859) NEUTE1DRAFT91925(NEUTE1DRAFT_91925)
SMPSMAC_01297 SMAC_05727
PANPODANSg3939 PODANSg5619
PBELQC761_109230(MNN9) QC761_114710(och1)
PPSDQC762_109230(MNN9) QC762_114710(och1)
TTTTHITE_2095073 THITE_2121506
MTMMYCTH_2106248 MYCTH_2297411 MYCTH_60177
CTHRCTHT_0014860 CTHT_0019180 CTHT_0057910
MGRMGG_00171 MGG_02859 MGG_05011 MGG_08652
PPEIPpBr36_03389 PpBr36_05778 PpBr36_08977 PpBr36_09260 PpBr36_10347 PpBr36_10775
PGRIPgNI_01294 PgNI_08023 PgNI_10515 PgNI_11737
TMNUCRPA7_2404 UCRPA7_8569
SSCKSPSK_09242 SPSK_09403
FGRFGSG_06856 FGSG_09425
FPUFPSE_07960 FPSE_11809
FPOAFPOAC1_010599 FPOAC1_012243
FVNFVRRES_11598 FVRRES_13327
FVRFVEG_03975 FVEG_05131
FOXFOXG_01971 FOXG_06111
NHENECHADRAFT_105919 NECHADRAFT_123326
FFCNCS54_00286700 NCS54_00561600
FKRNCS57_00282000 NCS57_00599500
FMUJ7337_002618 J7337_003980
TRETRIREDRAFT_58609 TRIREDRAFT_65646 TRIREDRAFT_80340
TRRM419DRAFT_124397 M419DRAFT_131661 M419DRAFT_74592
MAWMAC_00995 MAC_06842 MAC_08481
MAJMAA_05737 MAA_08458
PCHMVFPPC_00774 VFPPC_02981 VFPPC_10118
CMTCCM_05217 CCM_06374
AMUSLMH87_004972 LMH87_011232
PLJVFPFJ_05363 VFPFJ_06028
PTKZJDV02_000482 JDV02_001108(MNN9)
VALVDBG_02349 VDBG_04673
VDAVDAG_02820 VDAG_04214
CFJCFIO01_01535 CFIO01_03025
CLUPCLUP02_05583
CHIGCH63R_00695 CH63R_07086 CH63R_09786
SAPOSAPIO_CDS10094 SAPIO_CDS3303 SAPIO_CDS7989
ELAUCREL1_1692 UCREL1_7932 UCREL1_801 UCREL1_886
PFYPFICI_00433 PFICI_09035 PFICI_09794 PFICI_14506
SSLSS1G_02807 SS1G_03158
BFUBCIN_06g03220(Bcmnn9) BCIN_08g03990
MBEMBM_04797 MBM_07558
PSCOLY89DRAFT_313255 LY89DRAFT_594840 LY89DRAFT_676037 LY89DRAFT_699034
GLZGLAREA_01840 GLAREA_05012 GLAREA_05067 GLAREA_10699
ANIANIA_04716 ANIA_07672
AFMAFUA_2G01450 AFUA_5G08580
ACTACLA_011950 ACLA_033030 ACLA_093460
NFINFIA_033750 NFIA_078700
AORAO090120000208 AO090701000814
ANGAn03g05010 An07g04940
AFVAFLA_005322 AFLA_009426
ALUCAKAW2_11724A(OCH1_1) AKAW2_50871A(MNN9)
ACHEACHE_40559A(MNN9) ACHE_50551A(OCH1)
APUUAPUU_71012S(OCH1) APUU_80223A(MNN9)
PCSN7525_004734 N7525_008975
PDPPDIP_07370 PDIP_51700 PDIP_63540
POUPOX_a00184 POX_b03284
TMFEYB26_000622 EYB26_004026
TRGTRUGW13939_00569 TRUGW13939_03932 TRUGW13939_10718
CIMCIMG_00141 CIMG_06774
CPWCPC735_032020 CPC735_059970
UREUREG_00247 UREG_03690
PBLPAAG_03802 PAAG_04051 PAAG_05983
PBNPADG_03306 PADG_06012 PADG_07327
ABEARB_05752 ARB_06643
TVETRV_02425 TRV_04489
AJEHCAG_03327
BGHBDBG_01145 BDBG_06843
PNOSNOG_02920 SNOG_10597
PTEPTT_09202 PTT_11542 PTT_19588
BZECOCCADRAFT_10069 COCCADRAFT_26402 COCCADRAFT_41957 COCCADRAFT_6319 COCCADRAFT_95570
BSCCOCSADRAFT_173170 COCSADRAFT_232790 COCSADRAFT_40014 COCSADRAFT_41481
BORCOCMIDRAFT_101902 COCMIDRAFT_34243 COCMIDRAFT_368 COCMIDRAFT_4455
AALTCC77DRAFT_1030960 CC77DRAFT_1052656 CC77DRAFT_361229
ARABEKO05_0001181 EKO05_0007840
ZTRMYCGRDRAFT_103966 MYCGRDRAFT_33485 MYCGRDRAFT_70208
PFJMYCFIDRAFT_152600 MYCFIDRAFT_27664
FFUCLAFUR5_01012 CLAFUR5_05986
CBETCB0940_01079 CB0940_08082
BCOMBAUCODRAFT_285440 BAUCODRAFT_30856 BAUCODRAFT_75204
NPAUCRNP2_1719 UCRNP2_3813
TMLGSTUM_00004829001 GSTUM_00011096001
SPOSPAC1006.05c(och1) SPAC4F10.10c(mnn9)
SOMSOMG_03600(mnn9) SOMG_03933(och1)
CNECNA07230 CND03380 CNF01430
CNBCNBA7030 CNBD2980 CNBF3280
CNGCNAG_00744 CNAG_01214 CNAG_05836
CGICGB_A8320C CGB_D6060C CGB_F4610W
CDEUCNBG_0783 CNBG_1188 CNBG_1711
TMSTREMEDRAFT_16005 TREMEDRAFT_58229 TREMEDRAFT_61657 TREMEDRAFT_70437
TASAA1Q1_01062 A1Q1_01267
RSXRhiXN_01790
UMAUMAG_02624
PFPPFL1_01943
MLRMELLADRAFT_27594
SMINv1.2.008337.t1(symbB.v1.2.008337.t1) v1.2.008337.t2(symbB.v1.2.008337.t2) v1.2.009943.t1(symbB.v1.2.009943.t1) v1.2.035750.t1(symbB.v1.2.035750.t1)
TPSTHAPS_264481
AAFAURANDRAFT_63262 AURANDRAFT_66517
 » show all
Reference
1  [PMID:2644248]
  Authors
Romero PA, Herscovics A.
  Title
Glycoprotein biosynthesis in Saccharomyces cerevisiae. Characterization of alpha-1,6-mannosyltransferase which initiates outer chain formation.
  Journal
J Biol Chem 264:1946-50 (1989)
Reference
2  [PMID:1820199]
  Authors
Reason AJ, Dell A, Romero PA, Herscovics A.
  Title
Specificity of the mannosyltransferase which initiates outer chain formation in Saccharomyces cerevisiae.
  Journal
Glycobiology 1:387-91 (1991)
DOI:10.1093/glycob/1.4.387
Reference
3  [PMID:8253757]
  Authors
Nakanishi-Shindo Y, Nakayama K, Tanaka A, Toda Y, Jigami Y.
  Title
Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae.
  Journal
J Biol Chem 268:26338-45 (1993)
  Sequence
[sce:YGL038C]
Reference
4  [PMID:12784644]
  Authors
Yamamoto K, Okamoto M, Yoko-o T, Jigami Y.
  Title
Salt stress induces the expression of Schizosaccharomyces pombe och1+, which encodes an initiation-specific alpha-1,6-mannosyltransferase for N-linked outer chain synthesis of cell wall mannoproteins.
  Journal
Biosci Biotechnol Biochem 67:927-9 (2003)
DOI:10.1271/bbb.67.927
  Sequence
Reference
5  [PMID:11754484]
  Authors
Cui Z, Horecka J, Jigami Y.
  Title
Cdc4 is involved in the transcriptional control of OCH1, a gene encoding alpha-1,6-mannosyltransferase in Saccharomyces cerevisiae.
  Journal
Yeast 19:69-77 (2002)
DOI:10.1002/yea.801
Reference
6
  Authors
Tsukahara, K., Watanabe, T., Yoko-o, T. and Chigami, Y.
  Title
Schizosaccharomyces pombe och1+ gene encoding alpha-1,6-mannosyltransferase and use of och1+ gene knockout fission yeast for production of glycoproteins with reduced glycosylation.
  Journal
Jpn Kokai Tokkyo Koho Koho:11 (2001)
Reference
7  [PMID:9276464]
  Authors
Nakayama K, Nakanishi-Shindo Y, Tanaka A, Haga-Toda Y, Jigami Y.
  Title
Substrate specificity of alpha-1,6-mannosyltransferase that initiates N-linked mannose outer chain elongation in Saccharomyces cerevisiae.
  Journal
FEBS Lett 412:547-50 (1997)
DOI:10.1016/S0014-5793(97)00634-0
Reference
8  [PMID:8797833]
  Authors
Suzuki A, Shibata N, Suzuki M, Saitoh F, Takata Y, Oshie A, Oyamada H, Kobayashi H, Suzuki S, Okawa Y.
  Title
Characterization of alpha-1,6-mannosyltransferase responsible for the synthesis of branched side chains in Candida albicans mannan.
  Journal
Eur J Biochem 240:37-44 (1996)
DOI:10.1111/j.1432-1033.1996.0037h.x
Reference
9  [PMID:8146181]
  Authors
Yip CL, Welch SK, Klebl F, Gilbert T, Seidel P, Grant FJ, O'Hara PJ, MacKay VL
  Title
Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins.
  Journal
Proc Natl Acad Sci U S A 91:2723-7 (1994)
DOI:10.1073/pnas.91.7.2723
  Sequence
[sce:YPL050C]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.232
IUBMB Enzyme Nomenclature: 2.4.1.232
ExPASy - ENZYME nomenclature database: 2.4.1.232
BRENDA, the Enzyme Database: 2.4.1.232
CAS: 346003-17-6

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