initiation-specific alpha-1,6-mannosyltransferase;
alpha-1,6-mannosyltransferase;
GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase;
GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase;
glycolipid 6-alpha-mannosyltransferase;
GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase

Transferases;
Glycosyltransferases;
Hexosyltransferases

GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase

Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage

(other) R06986(G) R08599(G)

Requires Mn2+. In Saccharomyces cerevisiae, this enzyme catalyses an essential step in the outer chain elongation of N-linked oligosaccharides. Man8GlcNAc and Man9GlcNAc are equally good substrates.

1  [PMID:2644248]

Romero PA, Herscovics A.

Glycoprotein biosynthesis in Saccharomyces cerevisiae. Characterization of alpha-1,6-mannosyltransferase which initiates outer chain formation.

J. Biol. Chem. 264 (1989) 1946-50.

Saccharomyces cerevisiae [GN:sce]

2  [PMID:1820199]

Reason AJ, Dell A, Romero PA, Herscovics A.

Specificity of the mannosyltransferase which initiates outer chain formation in Saccharomyces cerevisiae.

Glycobiology. 1 (1991) 387-91.

Saccharomyces cerevisiae [GN:sce]

3  [PMID:8253757]

Nakanishi-Shindo Y, Nakayama K, Tanaka A, Toda Y, Jigami Y.

Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae.

J. Biol. Chem. 268 (1993) 26338-45.

Saccharomyces cerevisiae [GN:sce]

4  [PMID:12784644]

Yamamoto K, Okamoto M, Yoko-o T, Jigami Y.

Salt stress induces the expression of Schizosaccharomyces pombe och1+, which encodes an initiation-specific alpha-1,6-mannosyltransferase for N-linked outer chain synthesis of cell wall mannoproteins.

Biosci. Biotechnol. Biochem. 67 (2003) 927-9.

Schizosaccharomyces pombe [GN:spo]

5  [PMID:11754484]

Cui Z, Horecka J, Jigami Y.

Cdc4 is involved in the transcriptional control of OCH1, a gene encoding alpha-1,6-mannosyltransferase in Saccharomyces cerevisiae.

Yeast. 19 (2002) 69-77.

Saccharomyces cerevisiae [GN:sce]

6

Tsukahara, K., Watanabe, T., Yoko-o, T. and Chigami, Y.

Schizosaccharomyces pombe och1+ gene encoding alpha-1,6-mannosyltransferase and use of och1+ gene knockout fission yeast for production of glycoproteins with reduced glycosylation.

Jpn. Kokai Tokkyo Koho Koho (2001) 11.

7  [PMID:9276464]

Nakayama K, Nakanishi-Shindo Y, Tanaka A, Haga-Toda Y, Jigami Y.

Substrate specificity of alpha-1,6-mannosyltransferase that initiates N-linked mannose outer chain elongation in Saccharomyces cerevisiae.

FEBS. Lett. 412 (1997) 547-50.

Saccharomyces cerevisiae [GN:sce]

8  [PMID:8797833]

Suzuki A, Shibata N, Suzuki M, Saitoh F, Takata Y, Oshie A, Oyamada H, Kobayashi H, Suzuki S, Okawa Y.

Characterization of alpha-1,6-mannosyltransferase responsible for the synthesis of branched side chains in Candida albicans mannan.

Eur. J. Biochem. 240 (1996) 37-44.

Candida albicans [GN:cal]

9  [PMID:8146181]

Yip CL, Welch SK, Klebl F, Gilbert T, Seidel P, Grant FJ, O'Hara PJ, MacKay VL.

Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins.

Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 2723-7.

Saccharomyces cerevisiae [GN:sce]