KEGG   ENZYME: 2.4.1.244Help
Entry
EC 2.4.1.244                Enzyme                                 

Name
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase;
beta1,4-N-acetylgalactosaminyltransferase III;
beta4GalNAc-T3;
beta1,4-N-acetylgalactosaminyltransferase IV;
beta4GalNAc-T4;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Reaction(KEGG)
(other) R07610(G) R07611(G)
Show
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-glucosaminyl group
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Comment
The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end. The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
History
EC 2.4.1.244 created 2006
Pathway
Various types of N-glycan biosynthesis
Orthology
K09656  
beta-1,4-N-acetylgalactosaminyltransferase 3
K09657  
beta-1,4-N-acetylgalactosaminyltransferase 4
Genes
HSA: 
283358(B4GALNT3) 338707(B4GALNT4)
PTR: 
450920(B4GALNT4) 451738(B4GALNT3)
PPS: 
100976376(B4GALNT4) 100989611(B4GALNT3)
GGO: 
101131877(B4GALNT4) 101147545(B4GALNT3)
PON: 
100435319(B4GALNT3) 100457244(B4GALNT4)
NLE: 
100602613(B4GALNT4) 105738882(B4GALNT3)
MCC: 
706259(B4GALNT3) 720768(B4GALNT4)
MCF: 
102115389(B4GALNT4) 102145263(B4GALNT3)
CSAB: 
103218358(B4GALNT3) 103239139(B4GALNT4)
RRO: 
104656676(B4GALNT4) 104662541(B4GALNT3)
CJC: 
100407822(B4GALNT3) 100413834(B4GALNT4) 103796461
SBQ: 
101037149(B4GALNT4) 101054201(B4GALNT3)
MMU: 
330406(B4galnt3) 330671(B4galnt4)
RNO: 
309105(B4galnt4) 500306(B4galnt3)
CGE: 
100756528(B4galnt3) 100758404(B4galnt4)
NGI: 
103739368(B4galnt3) 103751068(B4galnt4)
HGL: 
101702463(B4galnt3) 101720559(B4galnt4)
OCU: 
100351156(B4GALNT3)
TUP: 
102476308(B4GALNT4) 102477252(B4GALNT3)
CFA: 
483398(B4GALNT4) 486751(B4GALNT3)
AML: 
100474848(B4GALNT4) 100481474(B4GALNT3)
UMR: 
103671083(B4GALNT4) 103675765(B4GALNT3)
FCA: 
101086091(B4GALNT4) 101097324(B4GALNT3)
PTG: 
102950331(B4GALNT4) 102953154(B4GALNT3)
BTA: 
100137759(B4GALNT4) 527026(B4GALNT3)
BOM: 
102275891(B4GALNT3) 102283950(B4GALNT4)
PHD: 
102317417(B4GALNT3) 102338750(B4GALNT4)
CHX: 
102172522(B4GALNT3) 102188023(B4GALNT4)
OAS: 
101105615(B4GALNT4) 101115274(B4GALNT3)
SSC: 
100623649(B4GALNT4)
CFR: 
102522276(B4GALNT4) 102523640(B4GALNT3)
BACU: 
103000329(B4GALNT4) 103019272(B4GALNT3)
LVE: 
103071788(B4GALNT4) 103084199(B4GALNT3)
ECB: 
100054676(B4GALNT4) 100056854(B4GALNT3)
MYB: 
102246590(B4GALNT4) 102254875(B4GALNT3)
MYD: 
102756317(B4GALNT3) 102761106(B4GALNT4)
PALE: 
102884317(B4GALNT4) 102884875(B4GALNT3)
LAV: 
100656658(B4GALNT4) 100665318(B4GALNT3)
MDO: 
100020793(B4GALNT3)
SHR: 
100918044(B4GALNT3) 100921988(B4GALNT4)
OAA: 
100080104(B4GALNT3)
GGA: 
418150(B4GALNT3) 770601(B4GALNT4)
MGP: 
100539296(B4GALNT4) 100543657(B4GALNT3)
CJO: 
107314272(B4GALNT4) 107315358(B4GALNT3)
APLA: 
101794410(B4GALNT3) 101795425(B4GALNT4)
TGU: 
100218099(B4GALNT4) 100221161(B4GALNT3)
GFR: 
102034690(B4GALNT4) 102036024(B4GALNT3)
FAB: 
101806677(B4GALNT4) 101814333(B4GALNT3)
PHI: 
102109686(B4GALNT3) 102112024(B4GALNT4)
CCW: 
104684539(B4GALNT4) 104692236(B4GALNT3)
FPG: 
101919553(B4GALNT4) 101920197(B4GALNT3)
FCH: 
102051612(B4GALNT4) 102055264(B4GALNT3)
CLV: 
102088828(B4GALNT4) 102090270(B4GALNT3)
AAM: 
106488281(B4GALNT3) 106489126(B4GALNT4) 106490584
ASN: 
102383192(B4GALNT3) 102384335(B4GALNT4)
AMJ: 
102563895(B4GALNT3) 102569972(B4GALNT4)
PSS: 
102450592(B4GALNT3) 102454912(B4GALNT4)
CMY: 
102944252(B4GALNT3) 102948034(B4GALNT4)
ACS: 
100552264(b4galnt3) 100568220(b4galnt4)
PBI: 
103050876(B4GALNT3) 103061436(B4GALNT4)
GJA: 
XTR: 
100036642(b4galnt4) 100488678(b4galnt3)
DRE: 
553524(b4galnt3b) 559305(b4galnt4b) 565184(b4galnt4a)
TRU: 
101067924(b4galnt3) 101067926(b4galnt4)
TNG: 
MZE: 
101471802(b4galnt4) 101485737(b4galnt3)
OLA: 
XMA: 
SASA: 
106560716(b4galnt4) 106561254(b4galnt3)
LCM: 
102348774(B4GALNT3) 102349555(B4GALNT4)
CMK: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
SRE: 
 » show all
Taxonomy
Reference
1  [PMID:12966086]
  Authors
Sato T, Gotoh M, Kiyohara K, Kameyama A, Kubota T, Kikuchi N, Ishizuka Y, Iwasaki H, Togayachi A, Kudo T, Ohkura T, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.
  Journal
J. Biol. Chem. 278 (2003) 47534-44.
  Sequence
[hsa:283358] [mmu:330406]
Reference
2  [PMID:15044014]
  Authors
Gotoh M, Sato T, Kiyohara K, Kameyama A, Kikuchi N, Kwon YD, Ishizuka Y, Iwai T, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine.
  Journal
FEBS. Lett. 562 (2004) 134-40.
  Sequence
[hsa:338707] [mmu:330671]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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