KEGG   ENZYME: 2.4.1.246Help
Entry
EC 2.4.1.246                Enzyme                                 

Name
mannosylfructose-phosphate synthase;
mannosylfructose-6-phosphate synthase;
MFPS
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + D-fructose 6-phosphate = GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate [RN:R08947]
Reaction(KEGG)
Substrate
GDP-mannose [CPD:C00096];
D-fructose 6-phosphate [CPD:C00085]
Product
GDP [CPD:C00035];
beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate [CPD:C18050]
Comment
This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ or Mn2+ for activity. GDP-mannose can be replaced by ADP-mannose but with a concomitant decrease in activity. The product of this reaction is dephosphorylated by EC 3.1.3.79 (mannosylfructose-phosphate phosphatase) to form the non-reducing disaccharide mannosylfructose, which is the major endogenous osmolyte produced by several alpha-proteobacteria in response to osmotic stress. The F in the product name is used to indicate that the fructose residue of sucrose carries the substituent.
History
EC 2.4.1.246 created 2008
Orthology
K13058  
mannosylfructose-phosphate synthase
Genes
ATU: 
AGR: 
RIR: 
OTE: 
Taxonomy
Reference
1  [PMID:17728402]
  Authors
Torres LL, Salerno GL
  Title
A metabolic pathway leading to mannosylfructose biosynthesis in Agrobacterium tumefaciens uncovers a family of mannosyltransferases.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 14318-23.
  Sequence
[atu:Atu0661]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
92480-04-1

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