KEGG   ENZYME: 2.4.1.252Help
Entry
EC 2.4.1.252                Enzyme                                 

Name
GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase;
GumH;
AceA;
alpha1,3-mannosyltransferase AceA
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol = GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [RN:R09733]
Reaction(KEGG)
Substrate
GDP-mannose [CPD:C00096];
D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [CPD:C19856]
Product
GDP [CPD:C00035];
D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [CPD:C19855]
Comment
In the bacterium Gluconacetobacter xylinus (previously known as Acetobacter xylinum) the enzyme is involved in the biosynthesis of the exopolysaccharide acetan [1]. In Xanthomonas campestris the enzyme is involved in the biosynthesis of the exopolysaccharide xanthan [5].
History
EC 2.4.1.252 created 2011
Orthology
K13657  
alpha-1,3-mannosyltransferase
Genes
XFA: 
XFT: 
PD1391(gumH)
XFM: 
XFN: 
XFF: 
XCC: 
XCC2448(gumH)
XCB: 
XCA: 
XCP: 
XCR_2761(gumH)
XCV: 
XCV2781(gumH)
XAC: 
XAC2579(gumH)
XCI: 
XAX: 
XACM_2561(gumH)
XAO: 
XOO: 
XOO3173(gumH)
XOM: 
XOP: 
PXO_01398(gumH)
XOR: 
XOC_1873(gumH)
PSD: 
CJA: 
CJA_0620(gt4J-2)
CFU: 
CFU_2732(gumH)
AZO: 
azo2237(gumH)
RET: 
REC: 
SJP: 
GDI: 
GDI_2550(gumH)
GDJ: 
GXY: 
 » show all
Taxonomy
Reference
1  [PMID:10485283]
  Authors
Geremia RA, Roux M, Ferreiro DU, Dauphin-Dubois R, Lellouch AC, Ielpi L
  Title
Expression and biochemical characterisation of recombinant AceA, a bacterial alpha-mannosyltransferase.
  Journal
Mol. Gen. Genet. 261 (1999) 933-40.
  Sequence
[gxy:GLX_27840]
Reference
2  [PMID:11001941]
  Authors
Abdian PL, Lellouch AC, Gautier C, Ielpi L, Geremia RA
  Title
Identification of essential amino acids in the bacterial alpha -mannosyltransferase aceA.
  Journal
J. Biol. Chem. 275 (2000) 40568-75.
  Sequence
[gxy:GLX_27840]
Reference
3  [PMID:8759843]
  Authors
Petroni EA, Ielpi L
  Title
Isolation and nucleotide sequence of the GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase gene from Acetobacter xylinum.
  Journal
J. Bacteriol. 178 (1996) 4814-21.
  Sequence
[gxy:GLX_27840]
Reference
4  [PMID:10872841]
  Authors
Lellouch AC, Watt GM, Geremia RA, Flitsch SL
  Title
Phytanyl-pyrophosphate-linked substrate for a bacterial alpha-mannosyltransferase.
  Journal
Biochem. Biophys. Res. Commun. 272 (2000) 290-2.
Reference
5  [PMID:9537354]
  Authors
Katzen F, Ferreiro DU, Oddo CG, Ielmini MV, Becker A, Puhler A, Ielpi L
  Title
Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence.
  Journal
J. Bacteriol. 180 (1998) 1607-17.
  Sequence
[xcc:XCC2448]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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