KEGG   ENZYME: 2.4.1.269Help
Entry
EC 2.4.1.269                Enzyme                                 

Name
mannosylglycerate synthase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:D-glycerate 2-alpha-D-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + D-glycerate = GDP + 2-O-(alpha-D-mannopyranosyl)-D-glycerate [RN:R09666]
Reaction(KEGG)
Substrate
GDP-mannose [CPD:C00096];
D-glycerate [CPD:C00258]
Product
GDP [CPD:C00035];
2-O-(alpha-D-mannopyranosyl)-D-glycerate
Comment
Rhodothermus marinus can also form mannosylglycerate via a two-step pathway catalysed by EC 2.4.1.217 (mannosyl-3-phosphoglycerate synthase) and EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase) [1]. Depending on experimental conditions mannosylglycerate synthase is more or less specific for the GDP-mannose and D-glycerate [1,2].
History
EC 2.4.1.269 created 2011
Reference
1  [PMID:10585410]
  Authors
Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H
  Title
Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase.
  Journal
J. Biol. Chem. 274 (1999) 35407-14.
Reference
2  [PMID:15951819]
  Authors
Flint J, Taylor E, Yang M, Bolam DN, Tailford LE, Martinez-Fleites C, Dodson EJ, Davis BG, Gilbert HJ, Davies GJ
  Title
Structural dissection and high-throughput screening of mannosylglycerate synthase.
  Journal
Nat. Struct. Mol. Biol. 12 (2005) 608-14.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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