KEGG   ENZYME: 2.4.1.274Help
Entry
EC 2.4.1.274                Enzyme                                 

Name
glucosylceramide beta-1,4-galactosyltransferase;
lactosylceramide synthase;
uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase;
UDP-Gal:glucosylceramide beta1->4galactosyltransferase;
GalT-2 (misleading);
UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03354 R06276]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-glucosyl-(1<->1)-ceramide [CPD:C01190]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Comment
Involved in the synthesis of several different major classes of glycosphingolipids.
History
EC 2.4.1.274 created 2011
Pathway
Sphingolipid metabolism
Metabolic pathways
Orthology
K07553  
beta-1,4-galactosyltransferase 6
Genes
HSA: 
9331(B4GALT6)
PTR: 
468512(B4GALT6)
PPS: 
100993210(B4GALT6)
GGO: 
101152268(B4GALT6)
PON: 
100455489(B4GALT6)
MCC: 
706068(B4GALT6)
MCF: 
102126845(B4GALT6)
MMU: 
56386(B4galt6)
RNO: 
65196(B4galt6)
CGE: 
100689438(B4galt6)
HGL: 
101726172(B4galt6)
TUP: 
102469566(B4GALT6)
CFA: 
490499(B4GALT6)
AML: 
100474316(B4GALT6)
FCA: 
101088368(B4GALT6)
PTG: 
102972031(B4GALT6)
BTA: 
524460(B4GALT6)
BOM: 
102267802(B4GALT6)
PHD: 
102340540(B4GALT6)
CHX: 
102182084(B4GALT6)
OAS: 
101114836(B4GALT6)
SSC: 
100517222(B4GALT6)
CFR: 
102503599(B4GALT6)
BACU: 
103020724(B4GALT6)
LVE: 
103088100(B4GALT6)
ECB: 
100052209(B4GALT6)
MYB: 
102262835(B4GALT6)
MYD: 
102754818(B4GALT6)
PALE: 
102890757(B4GALT6)
MDO: 
100024039(B4GALT6)
SHR: 
100919571(B4GALT6)
OAA: 
100084861(B4GALT6)
GGA: 
421092(B4GALT6)
MGP: 
TGU: 
100224001(B4GALT6)
FAB: 
101811130(B4GALT6)
PHI: 
102111801(B4GALT6)
APLA: 
101801239(B4GALT6)
FPG: 
101914158(B4GALT6)
FCH: 
102051198(B4GALT6)
CLV: 
102095761(B4GALT6)
ASN: 
102368658(B4GALT6)
AMJ: 
102558728(B4GALT6)
PSS: 
102452701(B4GALT6)
CMY: 
102935373(B4GALT6)
ACS: 
100564858(b4galt6)
PBI: 
103051698(B4GALT6)
XLA: 
779435(b4galt5)
XTR: 
548965(b4galt5)
DRE: 
393912(b4galt6)
TRU: 
MZE: 
OLA: 
LCM: 
102348772(B4GALT6)
CMK: 
103179660(b4galt6)
CIN: 
SPU: 
 » show all
Taxonomy
Reference
1  [PMID:3099851]
  Authors
Chatterjee S, Castiglione E
  Title
UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.
  Journal
Biochim. Biophys. Acta. 923 (1987) 136-42.
  Sequence
[hsa:9331]
Reference
2  [PMID:1900430]
  Authors
Trinchera M, Fiorilli A, Ghidoni R
  Title
Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide beta 1----4galactosyltransferase.
  Journal
Biochemistry. 30 (1991) 2719-24.
Reference
3  [PMID:1551920]
  Authors
Chatterjee S, Ghosh N, Khurana S
  Title
Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney.
  Journal
J. Biol. Chem. 267 (1992) 7148-53.
  Sequence
[hsa:9331]
Reference
4  [PMID:9593693]
  Authors
Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N
  Title
Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain.
  Journal
J. Biol. Chem. 273 (1998) 13570-7.
  Sequence
[rno:65196]
Reference
5  [PMID:10320813]
  Authors
Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, Inoue K, Hattori M, Matsuo N
  Title
cDNA cloning and expression of human lactosylceramide synthase.
  Journal
Biochim. Biophys. Acta. 1438 (1999) 301-4.
  Sequence
[hsa:9331]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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