KEGG   ENZYME: 2.4.1.275Help
Entry
EC 2.4.1.275                Enzyme                                 

Name
neolactotriaosylceramide beta-1,4-galactosyltransferase;
beta4Gal-T4;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase;
lactotriaosylceramide beta-1,4-galactosyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05977 R09755]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04922]
History
EC 2.4.1.275 created 2011, modified 2013
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K07969  
beta-1,4-galactosyltransferase 4
Genes
HSA: 
8702(B4GALT4)
PTR: 
100608173(B4GALT4)
PPS: 
100994562(B4GALT4)
GGO: 
PON: 
100443591(B4GALT4)
NLE: 
100600025(B4GALT4)
MCC: 
711983(B4GALT4)
MCF: 
102142820(B4GALT4)
RRO: 
104657610(B4GALT4)
CJC: 
100402903(B4GALT4)
MMU: 
56375(B4galt4)
RNO: 
303923(B4galt4)
CGE: 
100689435(B4galt4)
NGI: 
103741937(B4galt4)
HGL: 
101723638(B4galt4)
OCU: 
100357504(B4GALT4)
TUP: 
102470291(B4GALT4)
CFA: 
608143(B4GALT4)
AML: 
100481658(B4GALT4)
UMR: 
103678795(B4GALT4)
FCA: 
101100325(B4GALT4)
PTG: 
102966539(B4GALT4)
BTA: 
511328(B4GALT4)
BOM: 
102279871(B4GALT4)
PHD: 
102340702(B4GALT4)
CHX: 
102190262(B4GALT4)
OAS: 
101104949(B4GALT4)
CFR: 
102522848(B4GALT4)
BACU: 
103005928(B4GALT4)
LVE: 
103084555(B4GALT4)
ECB: 
100071082(B4GALT4)
MYB: 
102243483(B4GALT4)
MYD: 
102775104(B4GALT4)
PALE: 
102879802(B4GALT4)
MDO: 
100015888(B4GALT4)
SHR: 
100933479(B4GALT4)
GGA: 
418341(B4GALT4)
MGP: 
100547867(B4GALT4)
CJO: 
107320407(B4GALT4)
APLA: 
101792176(B4GALT4)
TGU: 
100230291(B4GALT4)
GFR: 
102034782(B4GALT4)
FAB: 
101809954(B4GALT4)
PHI: 
102108146(B4GALT4)
CCW: 
104687053(B4GALT4)
FPG: 
101915659(B4GALT4)
FCH: 
102051115(B4GALT4)
CLV: 
102093764(B4GALT4)
AAM: 
106490705(B4GALT4)
ASN: 
102370808(B4GALT4)
AMJ: 
102569919(B4GALT4)
PSS: 
102453780(B4GALT4)
CMY: 
102946330(B4GALT4)
ACS: 
100553568(b4galt4)
PBI: 
103068176(B4GALT4)
GJA: 
107106045(B4GALT4)
XLA: 
444709(b4galt4)
XTR: 
100488464(b4galt4)
DRE: 
492760(b4galt4)
TRU: 
101061200(b4galt4)
MZE: 
101466383(b4galt4)
OLA: 
101164915(b4galt4)
XMA: 
102221477(b4galt4)
LCM: 
CMK: 
103185094(b4galt4)
 » show all
Taxonomy
Reference
1  [PMID:9792633]
  Authors
Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H
  Title
Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid  biosynthesis.
  Journal
J. Biol. Chem. 273 (1998) 29331-40.
  Sequence
[hsa:8702]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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