KEGG   ENZYME: 2.4.1.277Help
Entry
EC 2.4.1.277                Enzyme                                 

Name
10-deoxymethynolide desosaminyltransferase;
glycosyltransferase DesVII;
DesVII
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase
Reaction(IUBMB)
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide = dTDP + 10-deoxymethymycin [RN:R06460]
Reaction(KEGG)
R06460;
(other) R06461
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Substrate
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose [CPD:C11911];
10-deoxymethynolide [CPD:C11993]
Product
dTDP [CPD:C00363];
10-deoxymethymycin [CPD:C11994]
Comment
DesVII is the glycosyltransferase responsible for the attachment of dTDP-D-desosamine to 10-deoxymethynolide or narbonolide during the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin in the bacterium Streptomyces venezuelae. Activity requires an additional protein partner, DesVIII.
History
EC 2.4.1.277 created 2011, modified 2014
Pathway
Biosynthesis of 12-, 14- and 16-membered macrolides
Biosynthesis of antibiotics
Orthology
K16004  
narbonolide/10-deoxymethynolide desosaminyltransferase
Reference
1  [PMID:20695498]
  Authors
Borisova SA, Liu HW
  Title
Characterization of glycosyltransferase DesVII and its auxiliary partner protein  DesVIII in the methymycin/picromycin biosynthetic pathway.
  Journal
Biochemistry. 49 (2010) 8071-84.
Reference
2  [PMID:18548476]
  Authors
Borisova SA, Kim HJ, Pu X, Liu HW
  Title
Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications.
  Journal
Chembiochem. 9 (2008) 1554-8.
Reference
3  [PMID:17049185]
  Authors
Hong JS, Park SJ, Parajuli N, Park SR, Koh HS, Jung WS, Choi CY, Yoon YJ
  Title
Functional analysis of desVIII homologues involved in glycosylation of macrolide  antibiotics by interspecies complementation.
  Journal
Gene. 386 (2007) 123-30.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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