KEGG   ENZYME: 2.4.1.278Help
Entry
EC 2.4.1.278                Enzyme                                 

Name
3-alpha-mycarosylerythronolide B desosaminyl transferase;
EryCIII;
dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose:3-alpha-mycarosylerythronolide B 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:3-alpha-mycarosylerythronolide B 3-dimethylamino-3,4,6-trideoxy-beta-D-glucosyltransferase
Reaction(IUBMB)
dTDP-D-desosamine + 3-alpha-L-mycarosylerythronolide B = dTDP + erythromycin D [RN:R05531]
Reaction(KEGG)
Substrate
dTDP-D-desosamine [CPD:C11911];
3-alpha-L-mycarosylerythronolide B [CPD:C06630]
Product
dTDP [CPD:C00363];
erythromycin D [CPD:C06633]
Comment
The enzyme is involved in erythromycin biosynthesis.
History
EC 2.4.1.278 created 2012, modified 2014
Pathway
Biosynthesis of 12-, 14- and 16-membered macrolides
Biosynthesis of antibiotics
Orthology
K14368  
3-alpha-mycarosylerythronolide B desosaminyl transferase
Genes
SEN: 
SACE_0726(eryCIII)
Taxonomy
Reference
1  [PMID:16218575]
  Authors
Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S
  Title
In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides.
  Journal
J. Am. Chem. Soc. 127 (2005) 14128-9.
  Sequence
[sen:SACE_0726]
Reference
2  [PMID:15303858]
  Authors
Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S
  Title
Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway.
  Journal
J. Am. Chem. Soc. 126 (2004) 9924-5.
  Sequence
[sen:SACE_0726]
Reference
3  [PMID:22056329]
  Authors
Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF
  Title
Structure of the glycosyltransferase EryCIII in complex with its activating P450  homologue EryCII.
  Journal
J. Mol. Biol. 415 (2012) 92-101.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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