KEGG   ENZYME: 2.4.1.285Help
Entry
EC 2.4.1.285                Enzyme                                 

Name
UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase;
neoK (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:ribostamycin N-acetylglucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + ribostamycin = UDP + 2'''-acetyl-6'''-hydroxyneomycin C [RN:R08900]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
ribostamycin [CPD:C01759]
Product
UDP [CPD:C00015];
2'''-acetyl-6'''-hydroxyneomycin C
Comment
Involved in biosynthesis of the aminoglycoside antibiotic neomycin. Requires a divalent metal ion, optimally Mg2+, Mn2+ or Co2+.
History
EC 2.4.1.285 created 2012
Pathway
Neomycin, kanamycin and gentamicin biosynthesis
Biosynthesis of antibiotics
Orthology
K13556  
UDP-N-acetyl-D-glucosamine:ribostamycin N-acetyl-D-glucosaminyltransferase
Reference
1  [PMID:18311744]
  Authors
Yokoyama K, Yamamoto Y, Kudo F, Eguchi T.
  Title
Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function  deacetylase in neomycin biosynthesis.
  Journal
Chembiochem. 9 (2008) 865-9.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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