KEGG   ENZYME: 2.4.1.287Help
Entry
EC 2.4.1.287                Enzyme                                 

Name
rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase;
arabinogalactan galactofuranosyl transferase 1;
GlfT1
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactofuranose:alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-beta/4-beta-galactofuranosyltransferase
Reaction(IUBMB)
2 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = 2 UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol (overall reaction);
(1a) UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol = UDP + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol;
(1b) UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol = UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
Substrate
UDP-alpha-D-galactofuranose [CPD:C03733];
alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [CPD:C20416];
alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol;
beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
Product
UDP [CPD:C00015];
beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol;
beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol;
beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
Comment
Isolated from Mycobacterium tuberculosis and M. smegmatis, the enzyme has dual beta-(1->4) and beta-(1->5) transferase action. Involved in the formation of the cell wall in mycobacteria.
History
EC 2.4.1.287 created 2012
Orthology
K16649  
rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase
Genes
MVR: 
ABS: 
ABQ: 
MTU: 
Rv3782(glfT1)
MTV: 
MTC: 
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUE: 
MTX: 
MTUL: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
MBB: 
MBT: 
MBM: 
MBK: 
MBX: 
MBZ: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MMIC: 
MLE: 
ML0113(rfbE)
MLB: 
MLBr00113(rfbE)
MPA: 
MAP_0240c(rfbE)
MAO: 
MAVI: 
MAVU: 
MAV: 
MAVD: 
MAVR: 
MAVA: 
MIT: 
MIR: 
MIA: 
MIE: 
MID: 
MYO: 
MSM: 
MSG: 
MSB: 
MSN: 
MSH: 
MSA: 
MUL: 
MVA: 
MGI: 
MSP: 
MAB: 
MABB: 
MMV: 
MAY: 
MABO: 
MABL: 
MAZ: 
MAK: 
MYS: 
MYC: 
MMC: 
MKM: 
MJL: 
MJD: 
MMI: 
MRH: 
MMM: 
MCB: 
MLI: 
MKN: 
MKS: 
MKI: 
MNE: 
MYV: 
MYE: 
MGO: 
MFT: 
MHAD: 
MPHL: 
ASD: 
CGL: 
NCgl0195(Cgl0198)
CGB: 
CGU: 
CGT: 
CGS: 
CGG: 
CGM: 
CGJ: 
CGQ: 
CGX: 
CEF: 
CDI: 
CDP: 
CDH: 
CDT: 
CDE: 
CDR: 
CDA: 
CDZ: 
CDB: 
CDS: 
CDD: 
CDW: 
CDV: 
CJK: 
CUR: 
CUA: 
CAR: 
CKP: 
CPU: 
CPL: 
CPG: 
Cp316_0122(glfT1)
CPP: 
CPK: 
CPQ: 
CPX: 
CpI19_0110(glfT1)
CPZ: 
COR: 
Cp267_0119(glfT1)
COP: 
Cp31_0123(glfT1)
COD: 
Cp106_0111(glfT1)
COS: 
COI: 
COE: 
Cp258_0122(glfT1)
COU: 
Cp162_0115(glfT1)
CPSE: 
CPSU: 
CPSF: 
CRD: 
CUL: 
CUC: 
CUE: 
CUN: 
CUS: 
CUQ: 
CUZ: 
CUJ: 
CVA: 
CHN: 
CCN: 
CTER: 
CMD: 
CAZ: 
CFN: 
CCG: 
CVT: 
CGY: 
CAX: 
CII: 
CUV: 
COA: 
DR71_1182(glfT1)
CDO: 
CHM: 
CSX: 
CMQ: 
B840_00815(glfT1)
CKU: 
UL82_00375(glfT1)
CCJ: 
UL81_00580(glfT1)
CMV: 
CEI: 
CTED: 
CUT: 
CLW: 
CDX: 
CDES_01130(glfT1)
NFA: 
NCY: 
NBR: 
NNO: 
RHA: 
RER: 
RER_02580(glfT)
REY: 
REB: 
ROP: 
ROP_39760(glfT)
ROA: 
REQ: 
RPY: 
RHB: 
RAV: 
GBR: 
GPO: 
GOR: 
GOQ: 
TPR: 
SRT: 
CBQ: 
ART: 
ARM: 
ARE: 
AAQ: 
ARH: 
ARW: 
ACH: 
APN: 
PSUL: 
KRH: 
KRH_09720(glfT)
KFV: 
PSIM: 
GOB: 
MMAR: 
SEN: 
SVI: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AJA: 
AJAP_01270(glfT1)
AMQ: 
ALU: 
PDX: 
PSEA: 
PSEE: 
PSEH: 
PSEQ: 
PECQ: 
AMI: 
SESP: 
BN6_01700(gtuS2-4)
KAL: 
KPHY: 
THC: 
TPI: 
EVI: 
 » show all
Taxonomy
Reference
1  [PMID:16952951]
  Authors
Mikusova K, Belanova M, Kordulakova J, Honda K, McNeil MR, Mahapatra S, Crick DC, Brennan PJ
  Title
Identification of a novel galactosyl transferase involved in biosynthesis of the  mycobacterial cell wall.
  Journal
J. Bacteriol. 188 (2006) 6592-8.
  Sequence
[mtu:Rv3782]
Reference
2  [PMID:18055597]
  Authors
Belanova M, Dianiskova P, Brennan PJ, Completo GC, Rose NL, Lowary TL, Mikusova K
  Title
Galactosyl transferases in mycobacterial cell wall synthesis.
  Journal
J. Bacteriol. 190 (2008) 1141-5.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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