KEGG   ENZYME: 2.4.1.289Help
Entry
EC 2.4.1.289                Enzyme                                 

Name
N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase;
WbbL
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-6-deoxy-beta-L-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-alpha-L-rhamnosyltransferase
Reaction(IUBMB)
dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [RN:R10175]
Reaction(KEGG)
Substrate
dTDP-6-deoxy-beta-L-mannose [CPD:C03319];
N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [CPD:C20390]
Product
dTDP [CPD:C00363];
alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [CPD:C20416]
Comment
Requires Mn2+ or Mg2+. Isolated from Mycobacterium smegmatis [1] and Mycobacterium tuberculosis [2]. The enzyme catalyses the addition of a rhamnosyl unit to N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol, completing the synthesis of the linkage unit that attaches the arabinogalactan moiety to the peptidoglycan moiety in Mycobacterial cell wall.
History
EC 2.4.1.289 created 2012
Orthology
K16870  N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
Genes
MTU: Rv3265c(wbbL1)
MTV: RVBD_3265c
MTC: MT3365
MRA: MRA_3306(wbbL1)
MTF: TBFG_13294
MTB: TBMG_03313
MTK: TBSG_03336
MTZ: TBXG_003293
MTG: MRGA327_20110
MTI: MRGA423_20465
MTUR: CFBS_3456(wbbL1)
MTO: MTCTRI2_3332(wbbL1)
MTD: UDA_3265c(wbbL1)
MTN: ERDMAN_3581(wbbL1)
MTUB: MT7199_3307(wbbL1)
MTUH: I917_22935
MTUL: TBHG_03201
MTUT: HKBT1_3443(wbbL1)
MTUU: HKBT2_3450(wbbL1)
MTQ: HKBS1_3453(wbbL1)
MBO: BQ2027_MB3293C(wbbL1)
MBB: BCG_3294c(wbbL1)
MBT: JTY_3290(wbbL1)
MBM: BCGMEX_3292c(wbbL1)
MBX: BCGT_3133
MAF: MAF_32760(wbbL1)
MCE: MCAN_32841(wbbL1)
MMIC: RN08_3601
MLE: ML0752(wbbL)
MLB: MLBr00752(wbbL)
MPA: MAP_3379c(wbbL)
MAO: MAP4_0403
MAVU: RE97_01935
MAV: MAV_4230
MAVD: NF84_19400
MAVR: LA63_19605
MAVA: LA64_19595
MIT: OCO_40880
MIA: OCU_40790
MIR: OCQ_42150
MID: MIP_06155
MYO: OEM_41140
MSG: MSMEI_1783(wbbL1)
MVA: Mvan_1728
MGI: Mflv_4735
MFT: XA26_18620(wbbL)
MPHL: MPHLCCUG_01623(wbbL)
MVQ: MYVA_1472
MUL: MUL_2611(wbbL1)
MAB: MAB_3612c
MABB: MASS_3619
MABO: NF82_18095
MCHE: BB28_18475
MSTE: MSTE_03745
MMC: Mmcs_1320
MKM: Mkms_1337
MJL: Mjls_1356
MJD: JDM601_3016(wbbL1)
MMI: MMAR_1276(wbbL1)
MMAE: MMARE11_12420(wbbL1)
MMM: W7S_20410
MLI: MULP_01437(wbbL)
MHAD: B586_17520
ASD: AS9A_3814(wbbL)
CGL: NCgl0709(Cgl0741)
CGB: cg0848(wbbL)
CGU: WA5_0709(WbbL)
CGT: cgR_0850
CGM: cgp_0848(wbbL)
CGJ: AR0_04280
CEF: CE0755
CDI: DIP0681
CDP: CD241_0620(wbbL)
CDH: CDB402_0594(wbbL)
CDT: CDHC01_0619(wbbL)
CDE: CDHC02_0625(wbbL)
CDR: CDHC03_0604(wbbL)
CDA: CDHC04_0585(wbbL)
CDZ: CD31A_0684(wbbL)
CDB: CDBH8_0642(wbbL)
CDS: CDC7B_0635(wbbL)
CDD: CDCE8392_0629(wbbL)
CDW: CDPW8_0681(wbbL)
CDV: CDVA01_0567(wbbL)
CDIP: ERS451417_00617(wbbL)
CJK: jk1646
CUR: cu0470
CUA: CU7111_0463(wbbL)
CAR: cauri_0658(wbbL)
CKP: ckrop_1519(wbbL)
CPU: cpfrc_00505(wbbL)
CPL: Cp3995_0509(wbbL)
CPG: Cp316_0523(wbbL)
CPP: CpP54B96_0508(wbbL)
CPK: Cp1002_0500(wbbL)
CPQ: CpC231_0504(wbbL)
CPX: CpI19_0503(wbbL)
CPZ: CpPAT10_0504(wbbL)
COR: Cp267_0523(wbbL)
COP: Cp31_0515(wbbL)
COD: Cp106_0491(wbbL)
COS: Cp4202_0495(wbbL)
COI: CpCIP5297_0513(wbbL)
COE: Cp258_0511(wbbL)
COU: Cp162_0502(wbbL)
CPSE: CPTA_01050
CPSU: CPTB_00483
CPSF: CPTC_00143
CRD: CRES_1734(wbbL)
CUL: CULC22_00561(wbbL)
CUC: CULC809_00554(wbbL)
CUN: Cul210932_0583(wbbL)
CUS: CulFRC11_0556(wbbL)
CUQ: Cul210931_0560(wbbL)
CUZ: Cul05146_0597(wbbL)
CUJ: CUL131002_0560(wbbL)
CVA: CVAR_2183
CTER: A606_08780
CGY: CGLY_04515(wbbL)
COA: DR71_1586(wbbL)
CSX: CSING_03665(wbbL)
CMQ: B840_02670(wbbL)
CKU: UL82_02350(wbbL)
CCJ: UL81_03050(wbbL)
CMV: CMUST_03800(wbbL)
CEI: CEPID_03205(wbbL)
CTED: CTEST_03085(wbbL)
CDX: CDES_03740(wbbL)
CSP: WM42_0714(wbbL)
CPHO: CPHO_09630
CGV: CGLAU_02795(wbbL)
CAQU: CAQU_02835
CAMG: CAMM_10040
NFA: NFA_46370
NFR: ERS450000_01716(wbbL_1) ERS450000_05291(wbbL_3)
NSR: NS506_02058(wbbL)
RER: RER_21480(wbbL)
REY: O5Y_10260
ROP: ROP_63700(wbbL)
REQ: REQ_33680
RHB: NY08_1687
RFA: A3L23_00051(wbbL_1)
RHS: A3Q41_03362(wbbL)
RHU: A3Q40_02038(wbbL)
GBR: Gbro_1854
GOR: KTR9_1791
TPR: Tpau_1063
SRT: Srot_2674
TWH: TWT_033(wbbL)
TWS: TW037
LXX: Lxx04940(wbbL)
AMIN: AUMI_11950
CFL: Cfla_2344
CFI: Celf_2488
FAL: FRAAL1254
NML: Namu_4181
GOB: Gobs_4318
MMAR: MODMU_4712
SEN: SACE_6472(wbbL)
AMD: AMED_1014
AMN: RAM_05160
AMM: AMES_1011
AMZ: B737_1012
AOI: AORI_0999
AJA: AJAP_34580(wbbL)
AMQ: AMETH_0925(wbbL)
PDX: Psed_5212
PSEA: WY02_11535
PSEE: FRP1_02675
PSEH: XF36_02080
AMI: Amir_6339
SESP: BN6_76290(gtuS2-20)
KAL: KALB_7919
ACTI: UA75_27220
ACAD: UA74_26630
AHG: AHOG_24550(wbbL2)
ALL: CRK59738
AHE: Arch_0059
TPYO: X956_02545
GES: VT84_15320(wbbL_2)
 » show all
Taxonomy
Reference
1  [PMID:15294902]
  Authors
Mills JA, Motichka K, Jucker M, Wu HP, Uhlik BC, Stern RJ, Scherman MS, Vissa VD, Pan F, Kundu M, Ma YF, McNeil M
  Title
Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability.
  Journal
J. Biol. Chem. 279 (2004) 43540-6.
  Sequence
[mtu:Rv3265c]
Reference
2  [PMID:19047740]
  Authors
Grzegorzewicz AE, Ma Y, Jones V, Crick D, Liav A, McNeil MR
  Title
Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL.
  Journal
Microbiology. 154 (2008) 3724-30.
  Sequence
[mtu:Rv3265c]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.289
IUBMB Enzyme Nomenclature: 2.4.1.289
ExPASy - ENZYME nomenclature database: 2.4.1.289
BRENDA, the Enzyme Database: 2.4.1.289

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