KEGG   ENZYME: 2.4.1.292Help
Entry
EC 2.4.1.292                Enzyme                                 

Name
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase;
PglH
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol 4-alpha-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
3 UDP-N-acetyl-alpha-D-galactosamine + GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol = 3 UDP + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Product
UDP [CPD:C00015];
[GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Comment
Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway.
History
EC 2.4.1.292 created 2012
Orthology
K17249  
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase
Genes
ABH: 
CJE: 
Cj1129c(pglH)
CJB: 
CJJ: 
CJU: 
C8J_1069(wlaC)
CJN: 
CJI: 
CJSA_1071(pglH)
CJM: 
CJM1_1107(capM)
CJS: 
CJS3_1175(pglH)
CJP: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJER: 
CJV: 
CJY: 
CJQ: 
UC78_1086(pglH)
CJL: 
CJW: 
CJR: 
CJE1271(pglH)
CJD: 
CJZ: 
CJX: 
CFF: 
CFT: 
CFV: 
CFX: 
CFZ: 
CAMP: 
CFP: 
CCV: 
CHA: 
CCO: 
CLA: 
Cla_1251(pglH)
CLR: 
CLM: 
CLQ: 
CLN: 
CLL: 
CCOL: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CCOF: 
VC76_05540(pglH_1)
CAJ: 
CIS: 
CINS_1216(pglH)
CVO: 
CVOL_1230(pglH)
CPEL: 
CPEL_1357(pglH)
CAMR: 
CSM: 
CSF: 
CGRA: 
CGRAC_1492(pglH1) CGRAC_1494(pglH2)
CURE: 
BIF: 
ZGA: 
 » show all
Taxonomy
Reference
1  [PMID:16186480]
  Authors
Glover KJ, Weerapana E, Imperiali B
  Title
In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 14255-9.
  Sequence
[cje:Cj1129c]
Reference
2  [PMID:19159314]
  Authors
Troutman JM, Imperiali B
  Title
Campylobacter jejuni PglH is a single active site processive polymerase that utilizes product inhibition to limit sequential glycosyl transfer reactions.
  Journal
Biochemistry. 48 (2009) 2807-16.
  Sequence
[cje:Cj1129c]
Reference
3  [PMID:21606362]
  Authors
Borud B, Viburiene R, Hartley MD, Paulsen BS, Egge-Jacobsen W, Imperiali B, Koomey M
  Title
Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 108 (2011) 9643-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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