KEGG   ENZYME: 2.4.1.302Help
Entry
EC 2.4.1.302                Enzyme                                 

Name
L-demethylnoviosyl transferase;
novM (gene name);
dTDP-beta-L-noviose:novobiocic acid 7-O-noviosyltransferase;
L-noviosyl transferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-4-O-demethyl-beta-L-noviose:novobiocic acid 7-O-[4-O-demethyl-L-noviosyl]transferase
Reaction(IUBMB)
dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = dTDP + demethyldecarbamoyl novobiocin [RN:R06770]
Reaction(KEGG)
Substrate
dTDP-4-O-demethyl-beta-L-noviose [CPD:C12481];
novobiocic acid [CPD:C12474]
Product
dTDP [CPD:C00363];
demethyldecarbamoyl novobiocin
Comment
The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin.
History
EC 2.4.1.302 created 2013, modified 2016
Pathway
Novobiocin biosynthesis
Biosynthesis of antibiotics
Orthology
K12711  
L-demethylnoviosyl transferase
Reference
1  [PMID:12680772]
  Authors
Freel Meyers CL, Oberthur M, Anderson JW, Kahne D, Walsh CT
  Title
Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.
  Journal
Biochemistry. 42 (2003) 4179-89.
  Sequence
Reference
2  [PMID:12633109]
  Authors
Albermann C, Soriano A, Jiang J, Vollmer H, Biggins JB, Barton WA, Lesniak J, Nikolov DB, Thorson JS
  Title
Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization.
  Journal
Org. Lett. 5 (2003) 933-6.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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