KEGG   ENZYME: 2.4.1.310Help
Entry
EC 2.4.1.310                Enzyme                                 

Name
vancomycin aglycone glucosyltransferase;
GtfB (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:vancomycin aglycone 48-O-beta-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + vancomycin aglycone = UDP + devancosaminyl-vancomycin [RN:R10594]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
vancomycin aglycone [CPD:C20719]
Product
UDP [CPD:C00015];
devancosaminyl-vancomycin [CPD:C20720]
Comment
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.4.1.310 created 2013
Pathway
ec01055  Biosynthesis of vancomycin group antibiotics
Orthology
K16444  vancomycin aglycone glucosyltransferase
Genes
LGU: LG3211_2060(gtfB)
LEZ: GLE_1936
LEM: LEN_3062
AGE: AA314_00618
CFUS: CYFUS_000252
SCU: SCE1572_48875
CMB: CSW64_17500
MPA: MAP_2871c
MAO: MAP4_0937
MAVI: RC58_04605
MAV: MAV_3653
MAVD: NF84_16615
MAVR: LA63_16775
MAVA: LA64_16770
NSR: NS506_05801(gtfB)
SCT: SCAT_p1593(rgt)
SBH: SBI_02990
SHY: SHJG_1904
SVE: SVEN_3444
STRE: GZL_07987
SPRI: SPRI_5993
SRW: TUE45_pSRc_0432(TUE45_pSRTUE45c_0432)
SLX: SLAV_16635(novM1) SLAV_35915(novM2)
LMOI: VV02_12065
KFL: Kfla_0374
TCU: Tcur_2526
SRO: Sros_5179
AMD: AMED_5501
AMI: Amir_3897
SESP: BN6_44490(gtuS1-3) BN6_68280(gtuS1-1)
MIL: ML5_5919
ASE: ACPL_4499(gtfE)
AFS: AFR_23425
ACTS: ACWT_4370
GBA: J421_6182
 » show all
Taxonomy
Reference
1  [PMID:11294642]
  Authors
Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT
  Title
Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.
  Journal
Biochemistry. 40 (2001) 4745-55.
Reference
2  [PMID:11470430]
  Authors
Mulichak AM, Losey HC, Walsh CT, Garavito RM
  Title
Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.
  Journal
Structure. 9 (2001) 547-57.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.310
IUBMB Enzyme Nomenclature: 2.4.1.310
ExPASy - ENZYME nomenclature database: 2.4.1.310
BRENDA, the Enzyme Database: 2.4.1.310

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