KEGG   ENZYME: 2.4.1.310Help
Entry
EC 2.4.1.310                Enzyme                                 

Name
vancomycin aglycone glucosyltransferase;
GtfB (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:vancomycin aglycone 48-O-beta-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + vancomycin aglycone = UDP + devancosaminyl-vancomycin [RN:R10594]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
vancomycin aglycone [CPD:C20719]
Product
UDP [CPD:C00015];
devancosaminyl-vancomycin [CPD:C20720]
Comment
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.4.1.310 created 2013
Pathway
Biosynthesis of vancomycin group antibiotics
Orthology
K16444  
vancomycin aglycone glucosyltransferase
Genes
LGU: 
LEZ: 
AGE: 
SCU: 
MPA: 
MAO: 
MAVI: 
MAV: 
MAVD: 
MAVR: 
MAVA: 
MSA: 
MRH: 
MNE: 
NBR: 
RHA: 
ROA: 
SCT: 
SCY: 
SBH: 
SHY: 
SHO: 
SVE: 
SALS: 
SRC: 
STRE: 
SPRI: 
SRW: 
TUE45_pSRc_0432(TUE45_pSRTUE45c_0432)
LMOI: 
KFL: 
TCU: 
SRO: 
FRE: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AJA: 
AMQ: 
ALU: 
AMI: 
SESP: 
BN6_44490(gtuS1-3) BN6_68280(gtuS1-1)
KAL: 
KPHY: 
LED: 
MAU: 
MIL: 
ASE: 
ACPL_4499(gtfE)
AFS: 
GBA: 
 » show all
Taxonomy
Reference
1  [PMID:11294642]
  Authors
Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT
  Title
Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.
  Journal
Biochemistry. 40 (2001) 4745-55.
Reference
2  [PMID:11470430]
  Authors
Mulichak AM, Losey HC, Walsh CT, Garavito RM
  Title
Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.
  Journal
Structure. 9 (2001) 547-57.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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