KEGG   ENZYME: 2.4.1.311Help
Entry
EC 2.4.1.311                Enzyme                                 

Name
chloroorienticin B synthase;
GtfA
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-L-4-epi-vancosamine:desvancosaminyl-vancomycin vancosaminyltransferase
Reaction(IUBMB)
dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin = dTDP + chloroorienticin B [RN:R10595]
Reaction(KEGG)
Substrate
dTDP-beta-L-4-epi-vancosamine [CPD:C12321];
desvancosaminyl-vancomycin [CPD:C20720]
Product
dTDP [CPD:C00363];
chloroorienticin B [CPD:C20721]
Comment
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.4.1.311 created 2013
Pathway
Biosynthesis of vancomycin group antibiotics
Orthology
K16440  
chloroorienticin B synthase
Genes
AJA: 
ALU: 
Taxonomy
Reference
1  [PMID:12874381]
  Authors
Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM
  Title
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 9238-43.
  Sequence
Reference
2  [PMID:15070728]
  Authors
Lu W, Oberthur M, Leimkuhler C, Tao J, Kahne D, Walsh CT
  Title
Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 4390-5.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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