KEGG   ENZYME: 2.4.1.312Help
Entry
EC 2.4.1.312                Enzyme                                 

Name
protein O-mannose beta-1,4-N-acetylglucosaminyltransferase;
GTDC2 (gene name);
POMGNT2
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-threonyl-[protein] 4-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] = UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [RN:R10596]
Reaction(KEGG)
R10596;
(other) R11407(G)
Show
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
3-O-(alpha-D-mannosyl)-L-threonyl-[protein] [CPD:C20722]
Product
UDP [CPD:C00015];
3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20723]
Comment
The human protein is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.
History
EC 2.4.1.312 created 2013
Pathway
Mannose type O-glycan biosynthesis
Metabolic pathways
Orthology
K18207  
protein O-mannose beta-1,4-N-acetylglucosaminyltransferase
Genes
HSA: 
84892(POMGNT2)
PTR: 
503649(POMGNT2)
PPS: 
100968652(POMGNT2)
GGO: 
101154402(POMGNT2)
PON: 
100457180(POMGNT2)
NLE: 
100592031(POMGNT2)
MCC: 
717032(POMGNT2)
MCF: 
102135133(POMGNT2)
CSAB: 
103227475(POMGNT2)
RRO: 
104670961(POMGNT2)
CJC: 
100387902(POMGNT2)
SBQ: 
101039365(POMGNT2)
MMU: 
215494(Pomgnt2)
RNO: 
316091(Pomgnt2)
CGE: 
100770708(Pomgnt2)
NGI: 
103747148(Pomgnt2)
HGL: 
101711700(Pomgnt2)
CCAN: 
109695103(Pomgnt2)
OCU: 
100341347(POMGNT2)
TUP: 
102470610(POMGNT2)
CFA: 
485621(POMGNT2)
AML: 
100483210(POMGNT2)
UMR: 
103682052(POMGNT2)
FCA: 
101093958(POMGNT2)
PTG: 
102955067(POMGNT2)
AJU: 
106966680(POMGNT2)
BTA: 
497030(POMGNT2)
BOM: 
102278967(POMGNT2)
BIU: 
109576335(POMGNT2)
PHD: 
CHX: 
102180708(POMGNT2)
OAS: 
101120611(POMGNT2)
SSC: 
100524525(POMGNT2)
CFR: 
102524427(POMGNT2)
BACU: 
ECB: 
100067004(POMGNT2)
MYB: 
102244479(POMGNT2)
MYD: 
102757264(POMGNT2)
HAI: 
109377834(POMGNT2)
RSS: 
109445290(POMGNT2)
PALE: 
102883663(POMGNT2)
LAV: 
100668532(POMGNT2)
MDO: 
100025375(POMGNT2)
SHR: 
100917448(POMGNT2)
OAA: 
100078600(POMGNT2)
GGA: 
428446(POMGNT2)
MGP: 
100549318(POMGNT2)
CJO: 
107309310(POMGNT2)
APLA: 
101800017(POMGNT2)
TGU: 
100220641(POMGNT2)
GFR: 
102034462(POMGNT2)
FAB: 
101807065(POMGNT2)
PHI: 
102114408(POMGNT2)
CCW: 
104689030(POMGNT2)
FPG: 
101913052(POMGNT2)
FCH: 
102054650(POMGNT2)
CLV: 
102097604(POMGNT2)
AAM: 
106491175(POMGNT2)
ASN: 
102376391(POMGNT2)
AMJ: 
102567043(POMGNT2)
PSS: 
102454469(POMGNT2)
CMY: 
102934275(POMGNT2)
CPIC: 
101953826(POMGNT2)
ACS: 
100557956(pomgnt2)
PBI: 
103067706(POMGNT2)
GJA: 
107111512(POMGNT2)
XLA: 
444520(pomgnt2.L)
XTR: 
496628(pomgnt2)
DRE: 
497644(pomgnt2)
IPU: 
108268718(pomgnt2)
TRU: 
777951(pomgnt2)
TNG: 
LCO: 
104923101(pomgnt2)
MZE: 
101467114(pomgnt2)
OLA: 
101172435(pomgnt2)
XMA: 
102225885(pomgnt2)
CSEM: 
103388754(pomgnt2)
SASA: 
LCM: 
102346285(POMGNT2)
CMK: 
103187059(pomgnt2)
BFO: 
SPU: 
SKO: 
PHU: 
ISC: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
HMG: 
TAD: 
CIT: 
CIC: 
GRA: 
GHI: 
EGR: 
LJA: 
Lj1g3v0000010.1(Lj1g3v0000010.1)
FVE: 
MDM: 
PXB: 
ZJU: 
CSV: 
CMO: 
POP: 
POPTR_0015s04170g(POPTRDRAFT_807898)
INI: 
SIND: 
BVG: 
ZMA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
MPP: 
CVR: 
SRE: 
ACAN: 
 » show all
Taxonomy
Reference
1  [PMID:23929950]
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science. 341 (2013) 896-9.
  Sequence
[hsa:84892]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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