KEGG   ENZYME: 2.4.1.313Help
Entry
EC 2.4.1.313                Enzyme                                 

Name
protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase;
B3GALNT2
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl-threonyl-[protein] 3-beta-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] = UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [RN:R10620]
Reaction(KEGG)
R10620;
(other) R07614(G)
Show
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20723]
Product
UDP [CPD:C00015];
3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20734]
Comment
The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor [1]. The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.
History
EC 2.4.1.313 created 2013
Pathway
Mannose type O-glycan biosynthesis
Metabolic pathways
Orthology
K09654  
beta-1,3-N-acetylgalactosaminyltransferase 2
Genes
HSA: 
148789(B3GALNT2)
PTR: 
469715(B3GALNT2)
PPS: 
100978307(B3GALNT2)
GGO: 
101140966(B3GALNT2)
PON: 
100443319(B3GALNT2)
NLE: 
100589286(B3GALNT2)
MCC: 
711550(B3GALNT2)
MCF: 
102146449(B3GALNT2)
CSAB: 
103230797(B3GALNT2)
RRO: 
104679172(B3GALNT2)
CJC: 
100413278(B3GALNT2)
SBQ: 
101046032(B3GALNT2)
MMU: 
97884(B3galnt2)
RNO: 
291212(B3galnt2)
CGE: 
100768564(B3galnt2)
NGI: 
103745134(B3galnt2)
HGL: 
101697517(B3galnt2)
OCU: 
100352278(B3GALNT2)
TUP: 
102477401(B3GALNT2)
CFA: 
479196(B3GALNT2)
AML: 
100484405(B3GALNT2)
UMR: 
103661896(B3GALNT2)
FCA: 
101085750(B3GALNT2)
PTG: 
102961022(B3GALNT2)
AJU: 
106982543(B3GALNT2)
BTA: 
100125310(B3GALNT2)
BOM: 
102280720(B3GALNT2)
PHD: 
102325807(B3GALNT2)
CHX: 
102178329(B3GALNT2)
OAS: 
101116957(B3GALNT2)
SSC: 
100620910(B3GALNT2)
CFR: 
102522922(B3GALNT2)
BACU: 
103018636(B3GALNT2)
LVE: 
103083400(B3GALNT2)
ECB: 
100058647(B3GALNT2)
MYB: 
102240384(B3GALNT2)
MYD: 
102762905(B3GALNT2)
HAI: 
109387715(B3GALNT2)
PALE: 
102897229(B3GALNT2)
LAV: 
100663890(B3GALNT2)
MDO: 
100617587(B3GALNT2)
SHR: 
100921524(B3GALNT2)
OAA: 
100081648(B3GALNT2)
GGA: 
430770(B3GALNT2)
MGP: 
100538415(B3GALNT2)
CJO: 
107311372(B3GALNT2)
APLA: 
101803248(B3GALNT2)
TGU: 
100218422(B3GALNT2)
GFR: 
102040498(B3GALNT2)
FAB: 
101813810(B3GALNT2)
PHI: 
102113102(B3GALNT2)
CCW: 
104684442(B3GALNT2)
FPG: 
101914116(B3GALNT2)
FCH: 
102053282(B3GALNT2)
CLV: 
102094245(B3GALNT2)
AAM: 
106486759(B3GALNT2)
ASN: 
102378749(B3GALNT2)
AMJ: 
102570410(B3GALNT2)
PSS: 
102458995(B3GALNT2)
CMY: 
102938135(B3GALNT2)
CPIC: 
101933681(B3GALNT2)
ACS: 
100557470(b3galnt2)
PBI: 
103057702(B3GALNT2)
GJA: 
107117761(B3GALNT2)
XLA: 
431874(b3galnt2.L)
XTR: 
496641(b3galnt2)
DRE: 
553716(b3galnt2)
IPU: 
108263411(b3galnt2)
TRU: 
101071098(b3galnt2)
TNG: 
LCO: 
104934548(b3galnt2)
MZE: 
101477300(b3galnt2)
OLA: 
101169879(b3galnt2)
XMA: 
102234069(b3galnt2)
SASA: 
106578767(b3galnt2)
LCM: 
102359133(B3GALNT2)
CMK: 
103178875(b3galnt2)
BFO: 
CIN: 
SPU: 
SKO: 
PHU: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
HMG: 
TAD: 
SRE: 
 » show all
Taxonomy
Reference
1  [PMID:14724282]
  Authors
Hiruma T, Togayachi A, Okamura K, Sato T, Kikuchi N, Kwon YD, Nakamura A, Fujimura K, Gotoh M, Tachibana K, Ishizuka Y, Noce T, Nakanishi H, Narimatsu H
  Title
A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc.
  Journal
J. Biol. Chem. 279 (2004) 14087-95.
  Sequence
[hsa:148789]
Reference
2  [PMID:23929950]
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science. 341 (2013) 896-9.
  Sequence
[hsa:148789]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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