KEGG   ENZYME: 2.4.1.316Help
Entry
EC 2.4.1.316                Enzyme                                 

Name
tylactone mycaminosyltransferase;
tylM2 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-alpha-D-mycaminose:tylactone 5-O-beta-D-mycaminosyltransferase
Reaction(IUBMB)
tylactone + dTDP-alpha-D-mycaminose = dTDP + 5-O-beta-D-mycaminosyltylactone [RN:R06450]
Reaction(KEGG)
Substrate
tylactone [CPD:C12000];
dTDP-alpha-D-mycaminose [CPD:C11933]
Product
dTDP [CPD:C00363];
5-O-beta-D-mycaminosyltylactone [CPD:C12001]
Comment
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. Activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene.
History
EC 2.4.1.316 created 2014
Pathway
Biosynthesis of 12-, 14- and 16-membered macrolides
Type I polyketide structures
Biosynthesis of antibiotics
Orthology
K15989  
tylactone mycaminosyltransferase
Reference
1  [PMID:9031628]
  Authors
Gandecha AR, Large SL, Cundliffe E
  Title
Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome.
  Journal
Gene. 184 (1997) 197-203.
  Sequence
Reference
2  [PMID:15612702]
  Authors
Melancon CE 3rd, Takahashi H, Liu HW
  Title
Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis.
  Journal
J. Am. Chem. Soc. 126 (2004) 16726-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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