KEGG   ENZYME: 2.4.1.317Help
Entry
EC 2.4.1.317                Enzyme                                 

Name
O-mycaminosyltylonolide 6-deoxyallosyltransferase;
tylN (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-6-deoxy-alpha-D-allose:5-O-beta-D-mycaminosyltylonolide 23-O-6-deoxy-alpha-D-allosyltransferase
Reaction(IUBMB)
5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = dTDP + demethyllactenocin [RN:R06451]
Reaction(KEGG)
Substrate
5-O-beta-D-mycaminosyltylonolide [CPD:C12002];
dTDP-6-deoxy-alpha-D-allose [CPD:C11912]
Product
dTDP [CPD:C00363];
demethyllactenocin [CPD:C12003]
Comment
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
History
EC 2.4.1.317 created 2014
Pathway
Biosynthesis of 12-, 14- and 16-membered macrolides
Biosynthesis of antibiotics
Orthology
K15993  
O-mycaminosyltylonolide 6-deoxyallosyltransferase
Reference
1  [PMID:9651492]
  Authors
Wilson VT, Cundliffe E
  Title
Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae.
  Journal
Gene. 214 (1998) 95-100.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system