KEGG   ENZYME: 2.4.1.318Help
Entry
EC 2.4.1.318                Enzyme                                 

Name
demethyllactenocin mycarosyltransferase;
tylCV (gene name);
tylC5 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-beta-L-mycarose:demethyllactenocin 4'-O-alpha-L-mycarosyltransferase
Reaction(IUBMB)
dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin [RN:R06452]
Reaction(KEGG)
Substrate
dTDP-beta-L-mycarose [CPD:C11916];
demethyllactenocin [CPD:C12003]
Product
dTDP [CPD:C00363];
demethylmacrocin [CPD:C02400]
Comment
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
History
EC 2.4.1.318 created 2014
Pathway
ec00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ec01130  Biosynthesis of antibiotics
Orthology
K15994  demethyllactenocin mycarosyltransferase
Reference
1  [PMID:10658660]
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology. 146 ( Pt 1) (2000) 139-46.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.318
IUBMB Enzyme Nomenclature: 2.4.1.318
ExPASy - ENZYME nomenclature database: 2.4.1.318
BRENDA, the Enzyme Database: 2.4.1.318

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