KEGG   ENZYME: 2.4.1.326Help
Entry
EC 2.4.1.326                Enzyme                                 

Name
aklavinone 7-L-rhodosaminyltransferase;
AknS/AknT;
aklavinone 7-beta-L-rhodosaminyltransferase;
dTDP-beta-L-rhodosamine:aklavinone 7-alpha-L-rhodosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-beta-L-rhodosamine:aklavinone 7-alpha-L-rhodosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
dTDP-beta-L-rhodosamine + aklavinone = dTDP + aclacinomycin T [RN:R09331]
Reaction(KEGG)
Substrate
dTDP-beta-L-rhodosamine [CPD:C18643];
aklavinone [CPD:C12424]
Product
dTDP [CPD:C00363];
aclacinomycin T [CPD:C18634]
Comment
Isolated from the bacterium Streptomyces galilaeus. Forms a complex with its accessory protein AknT, and has very low activity in its absence. The enzyme can also use dTDP-2-deoxy-beta-L-fucose. Involved in the biosynthesis of other aclacinomycins.
History
EC 2.4.1.326 created 2014, modified 2015
Pathway
Biosynthesis of type II polyketide products
Biosynthesis of antibiotics
Orthology
K15946  
aklavinone 7-alpha-L-rhodosaminyltransferase
Reference
1  [PMID:15911373]
  Authors
Lu W, Leimkuhler C, Gatto GJ Jr, Kruger RG, Oberthur M, Kahne D, Walsh CT
  Title
AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.
  Journal
Chem. Biol. 12 (2005) 527-34.
  Sequence
Reference
2  [PMID:17685523]
  Authors
Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D.
  Title
Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex  and its use in reconstituting the biosynthetic pathway of aclacinomycin A.
  Journal
J. Am. Chem. Soc. 129 (2007) 10546-50.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system