KEGG   ENZYME: 2.4.1.327Help
Entry
EC 2.4.1.327                Enzyme                                 

Name
aclacinomycin-T 2-deoxy-L-fucose transferase;
AknK
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-2-deoxy-beta-L-fucose:7-(alpha-L-rhodosaminyl)aklavinone 2-deoxy-alpha-L-fucosyltransferase
Reaction(IUBMB)
dTDP-2-deoxy-beta-L-fucose + aclacinomycin T = dTDP + aclacinomycin S [RN:R09332]
Reaction(KEGG)
Substrate
dTDP-2-deoxy-beta-L-fucose [CPD:C18636];
aclacinomycin T [CPD:C18634]
Product
dTDP [CPD:C00363];
aclacinomycin S [CPD:C18635]
Comment
The enzyme, isolated from the bacterium Streptomyces galilaeus, is involved in the biosynthesis of other aclacinomycins. Also acts on idarubicin. It will slowly add a second 2-deoxy-L-fucose unit to aclacinomycin S in vitro.
History
EC 2.4.1.327 created 2014
Pathway
Biosynthesis of type II polyketide products
Biosynthesis of antibiotics
Orthology
K15948  
aclacinomycin-T 2-deoxy-L-fucose transferase
Reference
1  [PMID:15078101]
  Authors
Lu W, Leimkuhler C, Oberthur M, Kahne D, Walsh CT.
  Title
AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.
  Journal
Biochemistry. 43 (2004) 4548-58.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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