KEGG   ENZYME: 2.4.1.328Help
Entry
EC 2.4.1.328                Enzyme                                 

Name
erythronolide mycarosyltransferase;
EryBV
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-beta-L-mycarose:erythronolide B L-mycarosyltransferase
Reaction(IUBMB)
dTDP-beta-L-mycarose + erythronolide B = dTDP + 3-alpha-L-mycarosylerythronolide B [RN:R05530]
Reaction(KEGG)
Substrate
dTDP-beta-L-mycarose [CPD:C11916];
erythronolide B [CPD:C06635]
Product
dTDP [CPD:C00363];
3-alpha-L-mycarosylerythronolide B [CPD:C06630]
Comment
Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin.
History
EC 2.4.1.328 created 2014
Pathway
Biosynthesis of 12-, 14- and 16-membered macrolides
Biosynthesis of antibiotics
Orthology
K14367  
erythronolide mycarosyltransferase
Genes
SEN: 
SACE_0719(eryBV)
Taxonomy
Reference
1  [PMID:17262863]
  Authors
Zhang C, Fu Q, Albermann C, Li L, Thorson JS
  Title
The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification.
  Journal
Chembiochem. 8 (2007) 385-90.
  Sequence
[sen:SACE_0719]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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