KEGG   ENZYME: 2.4.1.33Help
Entry
EC 2.4.1.33                 Enzyme                                 

Name
mannuronan synthase;
mannuronosyl transferase;
alginate synthase (incorrect);
alg8 (gene name);
alg44 (gene name);
GDP-D-mannuronate:alginate D-mannuronyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-alpha-D-mannuronate:mannuronan D-mannuronatetransferase
Reaction(IUBMB)
GDP-alpha-D-mannuronate + [(1->4)-beta-D-mannuronosyl]n = GDP + [(1->4)-beta-D-mannuronosyl]n+1 [RN:R08692]
Reaction(KEGG)
R08692;
(other) R03129
Show
Substrate
GDP-alpha-D-mannuronate;
[(1->4)-beta-D-mannuronosyl]n
Product
GDP [CPD:C00035];
[(1->4)-beta-D-mannuronosyl]n+1
Comment
The enzyme catalyses the polymerization of beta-D-mannuronate residues into a mannuronan polymer, an intermediate in the biosynthesis of alginate. It is found in brown algae and in alginate-producing bacterial species from the Pseudomonas and Azotobacter genera.
History
EC 2.4.1.33 created 1972, modified 2015
Pathway
Fructose and mannose metabolism
Orthology
K19290  
mannuronan synthase
K19291  
mannuronan synthase
Genes
NVE: 
PAE: 
PA3541(alg8) PA3542(alg44)
PAEV: 
PAEI: 
PAU: 
PA14_18550(alg44) PA14_18565(alg8)
PAP: 
PAG: 
PLES_14911(alg44) PLES_14921(alg8)
PAF: 
PAM18_1444(alg44) PAM18_1445(alg8)
PNC: 
NCGM2_4666(alg8) NCGM2_4667(alg44)
PAEB: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
PAEO: 
PMY: 
PMK: 
PRE: 
PPU: 
PPF: 
PPG: 
PPW: 
PPT: 
PPB: 
PPI: 
PPX: 
PPUH: 
PPUT: 
PPUN: 
PP4_07980(alg44) PP4_07990(alg8)
PPUD: 
PFV: 
PMON: 
PMOT: 
PMOS: 
PPJ: 
PST: 
PSB: 
PSYR: 
PSP: 
PCI: 
PFL: 
PPRC: 
PPRO: 
PFO: 
PFS: 
PFE: 
PFC: 
PFN: 
PFW: 
PFB: 
PFF: 
PPZ: 
PMAN: 
PTV: 
PEN: 
PSEEN4536(alg8) PSEEN4537(alg44)
PBA: 
PBC: 
PPUU: 
PDR: 
PSV: 
PSK: 
PKC: 
PKB_0966(alg44) PKB_0967(alg8)
PCH: 
PCZ: 
PCP: 
PFZ: 
PALK: 
PPV: 
PSES: 
PSEM: 
PSEC: 
PPSY: 
PSOS: 
AVN: 
Avin_10950(alg44) Avin_10960(alg8)
AVL: 
AvCA_10950(alg44) AvCA_10960(alg8)
AVD: 
ACX: 
Achr_31190(alg8) Achr_31200(alg44)
MSR: 
HHU: 
ABO: 
ABO_0385(alg8) ABO_0386(alg44)
ALN: 
GSN: 
TAU: 
NIS: 
RHL: 
DSH: 
RED: 
MALG: 
HAO: 
AAE: 
aq_1684(alg)
TAM: 
 » show all
Taxonomy
Reference
1  [PMID:5954796]
  Authors
Lin TY, Hassid WZ.
  Title
Pathway of algnic acid synthesis in the marine brown alga, Fucus gardneri Silva.
  Journal
J. Biol. Chem. 241 (1966) 5284-97.
Reference
2  [PMID:16391057]
  Authors
Remminghorst U, Rehm BH
  Title
In vitro alginate polymerization and the functional role of Alg8 in alginate production by Pseudomonas aeruginosa.
  Journal
Appl. Environ. Microbiol. 72 (2006) 298-305.
  Sequence
[pae:PA3541]
Reference
3  [PMID:18524915]
  Authors
Oglesby LL, Jain S, Ohman DE
  Title
Membrane topology and roles of Pseudomonas aeruginosa Alg8 and Alg44 in alginate  polymerization.
  Journal
Microbiology. 154 (2008) 1605-15.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37257-31-1

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