KEGG   ENZYME: 2.4.1.33Help
Entry
EC 2.4.1.33                 Enzyme                                 

Name
mannuronan synthase;
mannuronosyl transferase;
alginate synthase (incorrect);
alg8 (gene name);
alg44 (gene name);
GDP-D-mannuronate:alginate D-mannuronyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-alpha-D-mannuronate:mannuronan D-mannuronatetransferase
Reaction(IUBMB)
GDP-alpha-D-mannuronate + [(1->4)-beta-D-mannuronosyl]n = GDP + [(1->4)-beta-D-mannuronosyl]n+1 [RN:R08692]
Reaction(KEGG)
R08692;
(other) R03129
Show
Substrate
GDP-alpha-D-mannuronate;
[(1->4)-beta-D-mannuronosyl]n
Product
GDP [CPD:C00035];
[(1->4)-beta-D-mannuronosyl]n+1
Comment
The enzyme catalyses the polymerization of beta-D-mannuronate residues into a mannuronan polymer, an intermediate in the biosynthesis of alginate. It is found in brown algae and in alginate-producing bacterial species from the Pseudomonas and Azotobacter genera.
History
EC 2.4.1.33 created 1972, modified 2015
Pathway
Fructose and mannose metabolism
Reference
1  [PMID:5954796]
  Authors
Lin TY, Hassid WZ.
  Title
Pathway of algnic acid synthesis in the marine brown alga, Fucus gardneri Silva.
  Journal
J. Biol. Chem. 241 (1966) 5284-97.
Reference
2  [PMID:16391057]
  Authors
Remminghorst U, Rehm BH
  Title
In vitro alginate polymerization and the functional role of Alg8 in alginate production by Pseudomonas aeruginosa.
  Journal
Appl. Environ. Microbiol. 72 (2006) 298-305.
  Sequence
[pae:PA3541]
Reference
3  [PMID:18524915]
  Authors
Oglesby LL, Jain S, Ohman DE
  Title
Membrane topology and roles of Pseudomonas aeruginosa Alg8 and Alg44 in alginate  polymerization.
  Journal
Microbiology. 154 (2008) 1605-15.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37257-31-1

DBGET integrated database retrieval system