KEGG   ENZYME: 2.4.1.45Help
Entry
EC 2.4.1.45                 Enzyme                                 

Name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase;
uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase;
UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase;
UDP-galactose:ceramide galactosyltransferase;
UDP-galactose:2-2-hydroxyacylsphingosine galactosyltransferase;
UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase
Reaction(IUBMB)
UDP-alpha-D-galactose + a 2-(2-hydroxyacyl)sphingosine = UDP + a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine [RN:R04322]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
2-(2-hydroxyacyl)sphingosine [CPD:C03823]
Product
UDP [CPD:C00015];
1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine [CPD:C04708]
Comment
Highly specific.
History
EC 2.4.1.45 created 1972
Orthology
K04628  
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Genes
HSA: 
7368(UGT8)
PTR: 
461446(UGT8)
PPS: 
100985864(UGT8)
GGO: 
101137553(UGT8)
PON: 
MCC: 
702979(UGT8)
MCF: 
102126400(UGT8)
MMU: 
22239(Ugt8a)
RNO: 
50555(Ugt8)
CGE: 
HGL: 
101702896(Ugt8)
TUP: 
102480796(UGT8)
CFA: 
487910(UGT8)
AML: 
100465291(UGT8)
FCA: 
101097722(UGT8)
PTG: 
102965984(UGT8)
BTA: 
281566(UGT8)
BOM: 
102269259(UGT8)
PHD: 
102316197(UGT8)
CHX: 
102174638(UGT8)
OAS: 
101113069(UGT8)
SSC: 
CFR: 
102522568(UGT8)
BACU: 
103004850(UGT8)
LVE: 
103073438(UGT8)
ECB: 
100072587(UGT8)
MYB: 
102252842(UGT8)
PALE: 
102881397(UGT8)
MDO: 
100010696(UGT8)
SHR: 
OAA: 
100076336(UGT8)
GGA: 
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
100551810(ugt8)
PBI: 
103055483(UGT8)
XTR: 
779534(ugt8)
DRE: 
553508(ugt8)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
TAD: 
GMX: 
CSL: 
 » show all
Taxonomy
Reference
1  [PMID:5090043]
  Authors
Basu S, Schultz AM, Basu M, Roseman S.
  Title
Enzymatic synthesis of galactocerebroside by a galactosyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 246 (1971) 4272-9.
Reference
2  [PMID:5793706]
  Authors
Morell P, Radin NS.
  Title
Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid.
  Journal
Biochemistry. 8 (1969) 506-12.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37277-54-6

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