KEGG   ENZYME: 2.4.1.45Help
Entry
EC 2.4.1.45                 Enzyme                                 
Name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase;
uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase;
UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase;
UDP-galactose:ceramide galactosyltransferase;
UDP-galactose:2-2-hydroxyacylsphingosine galactosyltransferase;
UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase
Reaction(IUBMB)
UDP-alpha-D-galactose + a 2-(2-hydroxyacyl)sphingosine = UDP + a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine [RN:R04322]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
2-(2-hydroxyacyl)sphingosine [CPD:C03823]
Product
UDP [CPD:C00015];
1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine [CPD:C04708]
Comment
Highly specific.
Orthology
K04628  
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Genes
HSA: 
7368(UGT8)
PTR: 
461446(UGT8)
PPS: 
100985864(UGT8)
GGO: 
101137553(UGT8)
PON: 
MCC: 
702979(UGT8)
MMU: 
22239(Ugt8a)
RNO: 
50555(Ugt8)
CFA: 
487910(UGT8)
AML: 
100465291(UGT8)
FCA: 
101097722(UGT8)
BTA: 
281566(UGT8)
SSC: 
100511825
ECB: 
100072587(UGT8)
MDO: 
100010696
SHR: 
100914231 100927545
OAA: 
100076336(UGT8)
GGA: 
374033(UGT8) 428949
MGP: 
100539821 100541199
TGU: 
100228968 100231902(UGT8)
ACS: 
100551810(ugt8)
XTR: 
779534(ugt8)
DRE: 
553508(si:dkey-189j19.2)
TRU: 
101064956
OLA: 
101156303
BFO: 
BRAFLDRAFT_78254
TAD: 
TRIADDRAFT_2420
 » show all
Taxonomy
Reference
1  [PMID:5090043]
  Authors
Basu S, Schultz AM, Basu M, Roseman S.
  Title
Enzymatic synthesis of galactocerebroside by a galactosyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 246 (1971) 4272-9.
  Organism
Gallus gallus [GN:gga]
Reference
2  [PMID:5793706]
  Authors
Morell P, Radin NS.
  Title
Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid.
  Journal
Biochemistry. 8 (1969) 506-12.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37277-54-6
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