KEGG   ENZYME: 2.4.1.50Help
Entry
EC 2.4.1.50                 Enzyme                                 

Name
procollagen galactosyltransferase;
hydroxylysine galactosyltransferase;
collagen galactosyltransferase;
collagen hydroxylysyl galactosyltransferase;
UDP galactose-collagen galactosyltransferase;
uridine diphosphogalactose-collagen galactosyltransferase;
UDPgalactose:5-hydroxylysine-collagen galactosyltransferase;
UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine [RN:R03380]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
procollagen 5-hydroxy-L-lysine [CPD:C01211]
Product
UDP [CPD:C00015];
procollagen 5-(D-galactosyloxy)-L-lysine [CPD:C04487]
Comment
Probably involved in the synthesis of carbohydrate units in complement (cf. EC 2.4.1.66 procollagen glucosyltransferase).
History
EC 2.4.1.50 created 1972, modified 1983
Pathway
Lysine degradation
Other types of O-glycan biosynthesis
Orthology
K11703  
collagen beta-1,O-galactosyltransferase
K13646  
lysyl hydroxylase/galactosyltransferase/glucosyltransferase
Genes
HSA: 
23127(COLGALT2) 79709(COLGALT1) 8985(PLOD3)
PTR: 
455843(COLGALT1) 463618(PLOD3) 469611(COLGALT2)
PPS: 
100968399(PLOD3) 100982312(COLGALT1) 100992518(COLGALT2)
GGO: 
101137283(GLT25D2) 101150827(GLT25D1) 101151570(PLOD3)
PON: 
100189797(PLOD3) 100459610(GLT25D1)
NLE: 
100583272(COLGALT2) 100595902(COLGALT1) 100597272(PLOD3)
MCC: 
714283(PLOD3) 717508(COLGALT2) 719980(GLT25D1)
MCF: 
101865063(COLGALT2) 101867014(PLOD3) 102132871(COLGALT1)
CSAB: 
103230445(COLGALT2) 103234147(COLGALT1) 103246688(PLOD3)
RRO: 
104660965(COLGALT1) 104666808(COLGALT2) 104681188(PLOD3)
CJC: 
100389508(COLGALT2) 100390092(PLOD3) 100411398(COLGALT1)
SBQ: 
101031144(COLGALT1) 101041943(COLGALT2) 101043341(PLOD3)
MMU: 
234407(Colgalt1) 26433(Plod3) 269132(Colgalt2)
RNO: 
288583(Plod3) 289081(Colgalt2) 290637(Colgalt1)
CGE: 
100764465(Colgalt2) 100774081(Colgalt1)
NGI: 
103726669(Colgalt2) 103726894(Colgalt1) 103733492(Plod3)
HGL: 
101701075(Plod3) 101711193(Colgalt1) 101713780(Colgalt2)
OCU: 
TUP: 
102473246(COLGALT1) 102476916(PLOD3) 102489015(COLGALT2)
CFA: 
479730(PLOD3) 484834(COLGALT1) 608413(COLGALT2)
AML: 
100467880(COLGALT2) 100472987(COLGALT1) 100484476(PLOD3)
UMR: 
103670197(PLOD3) 103672506(COLGALT2) 103675173(COLGALT1)
FCA: 
101087701(COLGALT2) 101089668(PLOD3) 101091350(COLGALT1)
PTG: 
102950927(PLOD3) 102964832(COLGALT1) 102970872(COLGALT2)
BTA: 
513167(COLGALT1) 514996(PLOD3) 789150(COLGALT2)
BOM: 
102271514(COLGALT2) 102276636(PLOD3) 102285165(COLGALT1)
PHD: 
102321876(PLOD3) 102330626(COLGALT1) 102334725(COLGALT2)
CHX: 
100861039(PLOD3) 102172883(COLGALT1) 102173322(COLGALT2)
OAS: 
101107209(COLGALT2) 101114107(COLGALT1) 101121738(PLOD3)
SSC: 
100517457(COLGALT1) 100624420(PLOD3) 100624924(COLGALT2)
CFR: 
102505707(PLOD3) 102510366(COLGALT2) 102511754(COLGALT1)
BACU: 
103009205(COLGALT2) 103014456(COLGALT1) 103018042(PLOD3)
LVE: 
103070607(COLGALT2) 103079321(COLGALT1) 103090807(PLOD3)
ECB: 
100055683(COLGALT2) 100059479(PLOD3) 100070236(COLGALT1)
MYB: 
102245948(COLGALT2) 102249872(PLOD3) 102255507(COLGALT1)
MYD: 
102755224(PLOD3) 102764013(COLGALT2) 102768849(COLGALT1)
PALE: 
102879015(PLOD3) 102890053(COLGALT2) 102897385(COLGALT1)
LAV: 
100660775(COLGALT2) 100674443(COLGALT1) 100675876(PLOD3)
MDO: 
100014550(COLGALT1) 100017782(PLOD3) 100024267(COLGALT2)
SHR: 
100916266(COLGALT1) 100919157(COLGALT2) 100921874(PLOD3)
OAA: 
100085874(COLGALT2) 100086224(PLOD3) 103171451(COLGALT1)
GGA: 
107049863 424447(COLGALT2)
MGP: 
100540024(COLGALT2)
CJO: 
APLA: 
101799213(COLGALT2)
TGU: 
100232475(COLGALT2)
GFR: 
102039137(COLGALT2)
FAB: 
101810055(COLGALT2)
PHI: 
102106145(COLGALT2) 102111969(COLGALT1)
CCW: 
104693618(COLGALT2)
FPG: 
101911382(COLGALT1) 101921319(COLGALT2)
FCH: 
102046872(COLGALT1) 102051949(COLGALT2)
CLV: 
102091883(COLGALT1) 102093133(COLGALT2)
AAM: 
106495757(COLGALT2) 106500199(COLGALT1)
ASN: 
102378832(COLGALT2) 102379166(PLOD3) 102384904(COLGALT1)
AMJ: 
102557914(COLGALT1) 102561107(PLOD3) 106736985(COLGALT2)
PSS: 
102444350 102444474(PLOD3) 102449386(COLGALT2) 102452170(COLGALT1)
CMY: 
102940302(COLGALT2) 102942537(COLGALT1)
ACS: 
100556788(colgalt2) 100558042(plod3) 100566962(colgalt1) 103282019
PBI: 
103051832(PLOD3) 103058805(COLGALT1) 103059171(COLGALT2) 103067401
GJA: 
107114906(COLGALT1) 107117514(COLGALT2) 107118151(PLOD3)
XLA: 
100125229(colgalt1) 380138(plod3) 495521(colgalt1)
XTR: 
100488616(colgalt1) 100495682(colgalt2) 734090(plod3)
DRE: 
100003546(colgalt2) 556077(plod3) 558068 565862(colgalt1) 567859(colgalt1)
TRU: 
100101242(plod3) 101072217(colgalt2) 101072864 101078978(colgalt1)
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102347396(PLOD3) 102352198(CERCAM) 102356750(COLGALT2) 102363063(COLGALT1)
CMK: 
103172022 103172253(colgalt1) 103172951 103180076(colgalt2) 103183070(cercam)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DSI: 
Dsimw501_GD27319(Dsim_GD27319)
DWI: 
DYA: 
DMO: 
DVI: 
MDE: 
AGA: 
AgaP_AGAP012208(GLT25_ANOGA)
AAG: 
AaeL_AAEL003481(GLT25_AEDAE)
CQU: 
AME: 
413713(GB17277)
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
100141463(Cap-d3)
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_D2045.9(D2045.9)
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
MLR: 
SRE: 
SMIN: 
v1.2.030016.t1(symbB.v1.2.030016.t1)
 » show all
Taxonomy
Reference
1  [PMID:5722225]
  Authors
Bosmann HB, Eylar EH.
  Title
Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen.
  Journal
Biochem. Biophys. Res. Commun. 33 (1968) 340-6.
Reference
2
  Authors
Kivirikko, K.I. and Myllyla, R.
  Title
In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-07-3

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