KEGG   ENZYME: 2.4.1.50Help
Entry
EC 2.4.1.50                 Enzyme                                 

Name
procollagen galactosyltransferase;
hydroxylysine galactosyltransferase;
collagen galactosyltransferase;
collagen hydroxylysyl galactosyltransferase;
UDP galactose-collagen galactosyltransferase;
uridine diphosphogalactose-collagen galactosyltransferase;
UDPgalactose:5-hydroxylysine-collagen galactosyltransferase;
UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase;
UDP-alpha-D-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:[procollagen]-(2S,5R)-5-hydroxy-L-lysine 5-beta-D-galactosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [procollagen]-(2S,5R)-5-hydroxy-L-lysine = UDP + [procollagen]-(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine [RN:R03380]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
[procollagen]-(2S,5R)-5-hydroxy-L-lysine [CPD:C01211]
Product
UDP [CPD:C00015];
[procollagen]-(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
Comment
Involved in the synthesis of carbohydrate units in the complement system (cf. EC 2.4.1.66 procollagen glucosyltransferase).
History
EC 2.4.1.50 created 1972, modified 1983
Pathway
Lysine degradation
Other types of O-glycan biosynthesis
Orthology
K11703  
collagen beta-1,O-galactosyltransferase
K13646  
lysyl hydroxylase/galactosyltransferase/glucosyltransferase
Genes
HSA: 
23127(COLGALT2) 79709(COLGALT1) 8985(PLOD3)
PTR: 
107971907(PLOD3) 455843(COLGALT1) 463618(PLOD3) 469611(COLGALT2)
PPS: 
100968399(PLOD3) 100982312(COLGALT1) 100992518(COLGALT2)
GGO: 
101137283(GLT25D2) 101150827(GLT25D1) 101151570(PLOD3)
PON: 
100189797(PLOD3) 100459610(GLT25D1)
NLE: 
100583272(COLGALT2) 100595902(COLGALT1) 100597272(PLOD3)
MCC: 
714283(PLOD3) 717508(COLGALT2) 719980(GLT25D1)
MCF: 
101865063(COLGALT2) 101867014(PLOD3) 102132871(COLGALT1)
CSAB: 
103230445(COLGALT2) 103234147(COLGALT1) 103246688(PLOD3)
RRO: 
104660965(COLGALT1) 104666808(COLGALT2) 104681188(PLOD3)
CJC: 
100389508(COLGALT2) 100390092(PLOD3) 100411398(COLGALT1)
SBQ: 
101031144(COLGALT1) 101041943(COLGALT2) 101043341(PLOD3)
MMU: 
234407(Colgalt1) 26433(Plod3) 269132(Colgalt2)
RNO: 
288583(Plod3) 289081(Colgalt2) 290637(Colgalt1)
CGE: 
100764465(Colgalt2) 100774081(Colgalt1)
NGI: 
103726669(Colgalt2) 103726894(Colgalt1) 103733492(Plod3)
HGL: 
101701075(Plod3) 101711193(Colgalt1) 101713780(Colgalt2)
OCU: 
TUP: 
102473246(COLGALT1) 102476916(PLOD3) 102489015(COLGALT2)
CFA: 
479730(PLOD3) 484834(COLGALT1) 608413(COLGALT2)
AML: 
100467880(COLGALT2) 100472987(COLGALT1) 100484476(PLOD3)
UMR: 
103670197(PLOD3) 103672506(COLGALT2) 103675173(COLGALT1)
FCA: 
101087701(COLGALT2) 101089668(PLOD3) 101091350(COLGALT1)
PTG: 
102950927(PLOD3) 102964832(COLGALT1) 102970872(COLGALT2)
BTA: 
513167(COLGALT1) 514996(PLOD3) 789150(COLGALT2)
BOM: 
102271514(COLGALT2) 102276636(PLOD3) 102285165(COLGALT1)
PHD: 
102321876(PLOD3) 102330626(COLGALT1) 102334725(COLGALT2)
CHX: 
100861039(PLOD3) 102172883(COLGALT1) 102173322(COLGALT2)
OAS: 
101107209(COLGALT2) 101114107(COLGALT1) 101121738(PLOD3)
SSC: 
100517457(COLGALT1) 100624420(PLOD3) 100624924(COLGALT2)
CFR: 
102505707(PLOD3) 102510366(COLGALT2) 102511754(COLGALT1)
BACU: 
103009205(COLGALT2) 103014456(COLGALT1) 103018042(PLOD3)
LVE: 
103070607(COLGALT2) 103079321(COLGALT1) 103090807(PLOD3)
ECB: 
100055683(COLGALT2) 100059479(PLOD3) 100070236(COLGALT1)
MYB: 
102245948(COLGALT2) 102249872(PLOD3) 102255507(COLGALT1)
MYD: 
102755224(PLOD3) 102764013(COLGALT2) 102768849(COLGALT1)
PALE: 
102879015(PLOD3) 102890053(COLGALT2) 102897385(COLGALT1)
LAV: 
100660775(COLGALT2) 100674443(COLGALT1) 100675876(PLOD3)
MDO: 
100014550(COLGALT1) 100017782(PLOD3) 100024267(COLGALT2)
SHR: 
100916266(COLGALT1) 100919157(COLGALT2) 100921874(PLOD3)
OAA: 
100085874(COLGALT2) 100086224(PLOD3) 103171451(COLGALT1)
GGA: 
107049863 424447(COLGALT2)
MGP: 
100540024(COLGALT2)
CJO: 
APLA: 
101799213(COLGALT2)
TGU: 
100232475(COLGALT2)
GFR: 
102039137(COLGALT2)
FAB: 
101810055(COLGALT2)
PHI: 
102106145(COLGALT2) 102111969(COLGALT1)
CCW: 
104693618(COLGALT2)
FPG: 
101911382(COLGALT1) 101921319(COLGALT2)
FCH: 
102046872(COLGALT1) 102051949(COLGALT2)
CLV: 
102091883(COLGALT1) 102093133(COLGALT2)
AAM: 
106495757(COLGALT2) 106500199(COLGALT1)
ASN: 
102378832(COLGALT2) 102379166(PLOD3) 102384904(COLGALT1)
AMJ: 
102557914(COLGALT1) 102561107(PLOD3) 106736985(COLGALT2)
PSS: 
102444350 102444474(PLOD3) 102449386(COLGALT2) 102452170(COLGALT1)
CMY: 
102940302(COLGALT2) 102942537(COLGALT1)
ACS: 
100556788(colgalt2) 100558042(plod3) 100566962(colgalt1) 103282019
PBI: 
103051832(PLOD3) 103058805(COLGALT1) 103059171(COLGALT2) 103067401
GJA: 
107114906(COLGALT1) 107117514(COLGALT2) 107118151(PLOD3)
XLA: 
100125229(colgalt1.L) 108704485 108714512 108715018 380138(plod3.L) 495489 495521(colgalt1.S)
XTR: 
100488616(colgalt1) 100495682(colgalt2) 734090(plod3)
DRE: 
100003546(colgalt2) 556077(plod3) 558068 565862(colgalt1) 567859(colgalt1)
TRU: 
100101242(plod3) 101066165(cercam) 101072217(colgalt2) 101072864 101078978(colgalt1)
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102347396(PLOD3) 102352198(CERCAM) 102356750(COLGALT2) 102363063(COLGALT1)
CMK: 
103172022 103172253(colgalt1) 103172951 103180076(colgalt2) 103183070(cercam)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DSI: 
Dsimw501_GD27319(Dsim_GD27319)
DWI: 
DYA: 
DMO: 
DVI: 
MDE: 
AGA: 
AgaP_AGAP012208(GLT25_ANOGA)
AAG: 
AaeL_AAEL003481(GLT25_AEDAE)
CQU: 
AME: 
413713(GB17277)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
100141463(Cap-d3)
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_D2045.9(D2045.9)
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
MLR: 
SRE: 
SMIN: 
v1.2.030016.t1(symbB.v1.2.030016.t1)
 » show all
Taxonomy
Reference
1  [PMID:5722225]
  Authors
Bosmann HB, Eylar EH.
  Title
Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen.
  Journal
Biochem. Biophys. Res. Commun. 33 (1968) 340-6.
Reference
2
  Authors
Kivirikko, K.I. and Myllyla, R.
  Title
In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23.
Reference
3  [PMID:19075007]
  Authors
Schegg B, Hulsmeier AJ, Rutschmann C, Maag C, Hennet T
  Title
Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases.
  Journal
Mol. Cell. Biol. 29 (2009) 943-52.
  Sequence
[hsa:79709 23127]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-07-3

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