KEGG   ENZYME: 2.4.1.52Help
Entry
EC 2.4.1.52                 Enzyme                                 

Name
poly(glycerol-phosphate) alpha-glucosyltransferase;
UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase;
uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase;
tagE (gene name);
UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol alpha-D-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
n UDP-alpha-D-glucose + 4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-{poly[(2R)-2-alpha-D-glucosyl-1-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R04041]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Product
UDP [CPD:C00015];
4-O-{poly[(2R)-2-alpha-D-glucosyl-1-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Comment
Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme, isolated from Bacillus subtilis 168, adds an alpha-D-glucose to the free OH groups of the glycerol units. The enzyme has a strong preference for UDP-alpha-glucose as the sugar donor. It has no activity with poly(ribitol phosphate).
History
EC 2.4.1.52 created 1972, modified 2017
Orthology
K00712  
poly(glycerol-phosphate) alpha-glucosyltransferase
Genes
ETE: 
EDW: 
EDL: 
APJ: 
PGB: 
ABM: 
ACC: 
ALC: 
ACV: 
VBO: 
BSU: 
BSU35730(tagE)
BSR: 
BSH: 
BSUT: 
BSUL: 
BSO: 
BSN: 
BSQ: 
BSP: 
BAMP: 
BAMT: 
BAO: 
BAMF_3412(tagE)
BAZ: 
BQL: 
LL3_03707(tagE)
BXH: 
BPU: 
BPUS: 
BACW: 
BACL: 
BALM: 
BXI: 
BALT: 
TAP: 
VIG: 
VIL: 
VNE: 
SAU: 
SAV: 
SAW: 
SAH: 
SAJ: 
SAM: 
SAS: 
SAR: 
SAC: 
SAX: 
SAA: 
SAO: 
SAE: 
SAD: 
SUU: 
SUV: 
SUE: 
SUJ: 
SUK: 
SUC: 
SUT: 
SUQ: 
SUZ: 
SUD: 
SUX: 
SUW: 
SUG: 
SUF: 
SAUA: 
SAUE: 
SAUN: 
SAUS: 
SAUU: 
SAUG: 
SAUZ: 
SAUT: 
SAUJ: 
SAUK: 
SAUQ: 
SAUV: 
SAUW: 
SAUX: 
SAUY: 
SAB: 
SUY: 
SAUB: 
SAUM: 
SAUC: 
SAUR: 
SAUI: 
SAUD: 
SAUF: 
SAMS: 
SUH: 
SEP: 
SER: 
SEPP: 
SEPS: 
SCA: 
SCA_2110(tagE)
SLG: 
SLN: 
SDT: 
SWA: 
SPAS: 
SXY: 
SXL: 
SXO: 
SCAP: 
AYP1020_2024(gtf1_2) AYP1020_2025(tagE_1) AYP1020_2194(tagE_2) AYP1020_2313(tagE_3)
SSCH: 
SSCZ: 
SEQO: 
SSIF: 
SCV: 
SPET: 
SCOH: 
SSCU: 
SNL: 
SHV: 
EAN: 
EXM: 
EXU: 
KUR: 
LLA: 
L76469(yohH) L78550(yohJ)
LLK: 
LLKF_1561(yohH) LLKF_1562(yohJ)
LLT: 
LLS: 
lilo_1372(yohH) lilo_1373(yohJ)
LLD: 
LLX: 
LLJ: 
LG36_0924(yohJ) LG36_0925(yohH)
SPN: 
SGO: 
SGO_0975(gtaA)
LPL: 
lp_1299(tagE1) lp_1311(tagE2) lp_1312(tagE3) lp_2498(tagE4) lp_2843(tagE5) lp_2844(tagE6)
LPJ: 
JDM1_1099(tagE1) JDM1_1106(tagE2) JDM1_1107(tagE3) JDM1_2011(tagE4) JDM1_2280(tagE5) JDM1_2282(tagE6)
LPT: 
zj316_1318(tagE1) zj316_1319(tagE1) zj316_1327(tagE2) zj316_1328(tagE3) zj316_2429(tagE4) zj316_2714(tagE5) zj316_2715(tagE6)
LPS: 
LPST_C1052(tagE1) LPST_C1058(tagE2) LPST_C1059(tagE3) LPST_C2058(tagE4) LPST_C2332(tagE5) LPST_C2333(tagE6)
LPR: 
LPZ: 
LPB: 
LBR: 
LBK: 
LCA: 
LPQ: 
LPI: 
LPAP: 
LCB: 
LCABL_10040(tagE2) LCABL_10050(tagE3)
LCZ: 
LCS: 
LCE: 
LCW: 
LCL: 
LCX: 
LRE: 
LRF: 
LRU: 
LRT: 
LRR: 
LFE: 
LFR: 
LFF: 
LRH: 
LGG_00348(yohJ) LGG_00349(yohH) LGG_01586(yohH) LGG_01587(yohJ) LGG_02285(yohH)
LRG: 
LRL: 
LRA: 
LRO: 
LRC: 
LBH: 
LBN: 
LKE: 
LAW: 
LHO: 
LMU: 
LKO: 
LKU: 
LPX: 
LOR: 
LPAR: 
LCU: 
LBT: 
LAMY: 
LZY: 
LPG: 
PPE: 
PPEN: 
PCE: 
PDM: 
PACI: 
PIO: 
OOE: 
LME: 
LMM: 
LMK: 
LCI: 
LCK_01447(yohH)
LKI: 
LCN: 
WKO: 
WCB: 
WJO: 
WPA: 
MTS: 
MPAL: 
MIH: 
AGY: 
ARM: 
ACRY: 
AAI: 
IDO: 
I598_3340(tagE_2)
SERJ: 
BLY: 
BLIN: 
MGG: 
RBA: 
 » show all
Taxonomy
Reference
1  [PMID:14245359]
  Authors
GLASER L, BURGER MM.
  Title
THE SYNTHESIS OF TEICHOIC ACIDS. 3. GLUCOSYLATION OF POLYGLYCEROPHOSPHATE.
  Journal
J. Biol. Chem. 239 (1964) 3187-91.
Reference
2  [PMID:21558268]
  Authors
Allison SE, D'Elia MA, Arar S, Monteiro MA, Brown ED
  Title
Studies of the genetics, function, and kinetic mechanism of TagE, the wall teichoic acid glycosyltransferase in Bacillus subtilis 168.
  Journal
J. Biol. Chem. 286 (2011) 23708-16.
  Sequence
[bsu:BSU35730]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37277-60-4

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