KEGG   ENZYME: 2.4.1.62Help
Entry
EC 2.4.1.62                 Enzyme                                 
Name
ganglioside galactosyltransferase;
UDP-galactose---ceramide galactosyltransferase;
uridine diphosphogalactose-ceramide galactosyltransferase;
UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase;
UDP-galactose-GM2 galactosyltransferase;
uridine diphosphogalactose-GM2 galactosyltransferase;
uridine diphosphate D-galactose:glycolipid galactosyltransferase;
UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase;
UDP-galactose-GM2 ganglioside galactosyltransferase;
GM1-synthase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04631 R05941]
Reaction(KEGG)
R04631 R05941(G);
(other) R05110 R05111 R05948(G) R05953(G) R05956(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
The substrate is also known as gangloside GM2, the product as gangloside GM1a
Pathway
Other types of O-glycan biosynthesis
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
Orthology
K00715  
ganglioside galactosyltransferase
Genes
HSA: 
8705(B3GALT4)
PTR: 
746800(B3GALT4)
PPS: 
100990558(B3GALT4)
GGO: 
101147230(B3GALT4)
PON: 
100431810(B3GALT4)
MCC: 
718178(B3GALT4)
MMU: 
54218(B3galt4)
RNO: 
171079(B3galt4)
CFA: 
481737(B3GALT4)
AML: 
FCA: 
101087480(B3GALT4)
BTA: 
768038(B3GALT4)
SSC: 
100155431
ECB: 
100052704
MDO: 
100618101
SHR: 
100932392(B3GALT4)
XTR: 
100489366
TRU: 
101065804
OLA: 
101168709
 » show all
Taxonomy
Reference
1  [PMID:5842076]
  Authors
Basu S, Kaufman B, Roseman S.
  Title
Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase.
  Journal
J. Biol. Chem. 240 (1965) 4115-7.
  Organism
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc], Gallus gallus [GN:gga]
Reference
2  [PMID:4987145]
  Authors
Yip GB, Dain JA.
  Title
The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain.
  Journal
Biochim. Biophys. Acta. 206 (1970) 252-60.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:5484669]
  Authors
Yip MC, Dain JA.
  Title
Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceram ide galactosyltransferase.
  Journal
Biochem. J. 118 (1970) 247-52.
  Organism
frog
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37217-28-0
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