KEGG   ENZYME: 2.4.1.66Help
Entry
EC 2.4.1.66                 Enzyme                                 

Name
procollagen glucosyltransferase;
galactosylhydroxylysine glucosyltransferase;
collagen glucosyltransferase;
collagen hydroxylysyl glucosyltransferase;
galactosylhydroxylysyl glucosyltransferase;
UDP-glucose-collagenglucosyltransferase;
uridine diphosphoglucose-collagen glucosyltransferase;
UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-glucose:(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen] D-glucosyltransferase
Reaction(IUBMB)
UDP-glucose + (2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen] = UDP + (2S,5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine-[procollagen] [RN:R04491]
Reaction(KEGG)
Substrate
UDP-glucose [CPD:C00029];
(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen]
Product
UDP [CPD:C00015];
(2S,5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine-[procollagen]
Comment
Probably involved in the synthesis of carbohydrate units in complement (cf. EC 2.4.1.50 procollagen galactosyltransferase).
History
EC 2.4.1.66 created 1972
Pathway
Other types of O-glycan biosynthesis
Orthology
K13646  
lysyl hydroxylase/galactosyltransferase/glucosyltransferase
Genes
HSA: 
8985(PLOD3)
PTR: 
463618(PLOD3)
PPS: 
100968399(PLOD3)
GGO: 
101151570(PLOD3)
PON: 
100189797(PLOD3)
NLE: 
100597272(PLOD3)
MCC: 
714283(PLOD3)
MCF: 
101867014(PLOD3)
RRO: 
104681188(PLOD3)
CJC: 
100390092(PLOD3)
MMU: 
26433(Plod3)
RNO: 
288583(Plod3)
NGI: 
103733492(Plod3)
HGL: 
101701075(Plod3)
OCU: 
TUP: 
102476916(PLOD3)
CFA: 
479730(PLOD3)
AML: 
100484476(PLOD3)
UMR: 
103670197(PLOD3)
FCA: 
101089668(PLOD3)
PTG: 
102950927(PLOD3)
BTA: 
514996(PLOD3)
BOM: 
102276636(PLOD3)
PHD: 
102321876(PLOD3)
CHX: 
100861039(PLOD3)
OAS: 
101121738(PLOD3)
SSC: 
100624420(PLOD3)
CFR: 
102505707(PLOD3)
BACU: 
103018042(PLOD3)
LVE: 
103090807(PLOD3)
ECB: 
100059479(PLOD3)
MYB: 
102249872(PLOD3)
MYD: 
102755224(PLOD3)
PALE: 
102879015(PLOD3)
MDO: 
100017782(PLOD3)
SHR: 
100921874(PLOD3)
OAA: 
100086224(PLOD3)
ASN: 
102379166(PLOD3)
AMJ: 
102561107(PLOD3)
PSS: 
102444474(PLOD3)
ACS: 
100558042(plod3)
PBI: 
GJA: 
107118151(PLOD3)
XLA: 
380138(plod3)
XTR: 
734090(plod3)
DRE: 
556077(plod3)
TRU: 
100101242(plod3)
MZE: 
101473400(plod3)
OLA: 
XMA: 
LCM: 
102347396(PLOD3)
CIN: 
TSP: 
HRO: 
CRG: 
AQU: 
SRE: 
 » show all
Taxonomy
Reference
1  [PMID:5637038]
  Authors
Bosmann HB, Eylar EH.
  Title
Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase.
  Journal
Biochem. Biophys. Res. Commun. 30 (1968) 89-94.
Reference
2  [PMID:4968368]
  Authors
Bosmann HB, Eylar EH.
  Title
Collagen-glucosyl transferase in fibriblasts transformed by oncogenic viruses.
  Journal
Nature. 218 (1968) 582-3.
Reference
3  [PMID:4288358]
  Authors
Butler WT, Cunningham LW.
  Title
Evidence for the linkage of a disaccharide to hydroxylysine in tropocollagen.
  Journal
J. Biol. Chem. 241 (1966) 3882-8.
Reference
4
  Authors
Kivirikko, K.I. and Myllyla, R.
  Title
In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-08-4

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