KEGG   ENZYME: 2.4.1.69Help
Entry
EC 2.4.1.69                 Enzyme                                 

Name
type 1 galactoside alpha-(1,2)-fucosyltransferase;
galactoside 2-alpha-L-fucosyltransferase (ambiguous);
blood group H alpha-2-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase;
alpha-(1->2)-L-fucosyltransferase (ambiguous);
alpha-2-fucosyltransferase (ambiguous);
alpha-2-L-fucosyltransferase (ambiguous);
blood-group substance H-dependent fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase (ambiguous);
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase (ambiguous);
secretor-type beta-galactoside alpha1->2fucosyltransferase;
beta-galactoside alpha1->2fucosyltransferase (ambiguous);
GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase (ambiguous);
FUT2 (gene name);
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 2-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:R04081]
Reaction(KEGG)
R04081 > R05968(G) R06024(G) R06031(G) R06035(G) R06041(G) R06085(G) R06086(G) R06089(G) R06090(G) R06156(G);
(other) R06170(G)
Show
Substrate
GDP-beta-L-fucose [CPD:C00325];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Product
GDP [CPD:C00035];
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
History
EC 2.4.1.69 created 1972 (EC 2.4.1.89 created 1976, incorporated 1984), modified 2002, modified 2017
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - globo and isoglobo series
Metabolic pathways
Orthology
K00718  
galactoside 2-L-fucosyltransferase 1/2
K12245  
bifunctional glycosyltransferase PgtA
Genes
HSA: 
2523(FUT1) 2524(FUT2)
PTR: 
104001169 468944(FUT2) 468947(FUT1)
PPS: 
GGO: 
101131113(FUT1) 101148312(FUT2)
PON: 
NLE: 
MCC: 
718252(FUT1) 722582(FUT2)
MCF: 
CSAB: 
RRO: 
CJC: 
100389529(FUT1) 100896666(FUT2)
SBQ: 
MMU: 
14343(Fut1) 14344(Fut2) 56546(Sec1)
RNO: 
308586(Sec1) 58924(Fut2) 81919(Fut1)
CGE: 
NGI: 
HGL: 
101709834(Fut1) 101710190(Fut2)
OCU: 
TUP: 
CFA: 
102151792 484396(FUT1) 484398(FUT2)
AML: 
UMR: 
FCA: 
101080847(FUT1) 101085847(FUT2)
PTG: 
102962287(FUT2) 102969895(FUT1)
AJU: 
BTA: 
281174(FUT1) 281175(FUT2) 281483(SEC1)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
100524201(FUT2A) 100738225 397138(FUT1) 397139(FUT2)
CFR: 
BACU: 
103015344(FUT1)
LVE: 
103080875(FUT2) 103081703(FUT1)
ECB: 
MYB: 
102257351(FUT1) 102259445(FUT2)
MYD: 
HAI: 
109391063(FUT2) 109391098(FUT1)
PALE: 
102885708(FUT1) 102886704(FUT2)
LAV: 
MDO: 
SHR: 
OAA: 
100085980(FUT1) 100681084(FUT2)
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
100561462(fut2)
PBI: 
103053688(FUT2)
GJA: 
107122202(FUT2)
XLA: 
108696739 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)
XTR: 
LCM: 
CMK: 
AME: 
726095(GB16372)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
PHU: 
DPX: 
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
DDI: 
DPP: 
DFA: 
DFA_01805(pgtA)
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:7372640]
  Authors
Beyer TA, Hill RL.
  Title
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J. Biol. Chem. 255 (1980) 5373-9.
Reference
2  [PMID:6246105]
  Authors
Beyer TA, Sadler JE, Hill RL.
  Title
Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J. Biol. Chem. 255 (1980) 5364-72.
Reference
3  [PMID:6588382]
  Authors
Kumazaki T, Yoshida A
  Title
Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 81 (1984) 4193-7.
Reference
4  [PMID:9219535]
  Authors
Koda Y, Soejima M, Wang B, Kimura H
  Title
Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).
  Journal
Eur. J. Biochem. 246 (1997) 750-5.
Reference
5  [PMID:10589734]
  Authors
Wang G, Boulton PG, Chan NW, Palcic MM, Taylor DE
  Title
Novel Helicobacter pylori alpha1,2-fucosyltransferase, a key enzyme in the synthesis of Lewis antigens.
  Journal
Microbiology. 145 ( Pt 11) (1999) 3245-53.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
56093-23-3

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