KEGG   ENZYME: 2.4.1.70Help
Entry
EC 2.4.1.70                 Enzyme                                 

Name
poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase;
TarM;
UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase (ambiguous);
uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase (ambiguous);
UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase (ambiguous);
UDP-N-acetyl-alpha-D-glucosamine:poly(ribitol-phosphate) N-acetyl-alpha-D-glucosaminyltransferase (ambiguous);
poly(ribitol-phosphate) N-acetylglucosaminyltransferase (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol alpha-N-acetyl-D-glucosaminyltransferase (configuration-retaining)
Reaction(IUBMB)
n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N-acetyl-alpha-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R12037]
Reaction(KEGG)
R12037;
(other) R02717 R06182(G)
Show
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]
Product
UDP [CPD:C00015];
4-O-(2-N-acetyl-alpha-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21870]
Comment
Involved in the biosynthesis of poly(ribitol phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-alpha-D-glucosamine to the hydroxyl group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.355 [poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase].
History
EC 2.4.1.70 created 1972, modified 2018
Orthology
K22710  poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase
Genes
SAM: MW0919
SAS: SAS0971
SAC: SACOL1043
SAX: USA300HOU_0984
SAA: SAUSA300_0939
SAE: NWMN_0906
SUV: SAVC_04345
SUJ: SAA6159_00892
SUK: SAA6008_00990
SUT: SAT0131_01070
SUZ: MS7_0993
SAUA: SAAG_02146
SAUF: X998_1035
SAB: SAB0901
SAUM: BN843_9420
SAUR: SABB_01002
SAUI: AZ30_04940
SSCH: LH95_01430
 » show all
Taxonomy
Reference
1
  Authors
Nathenson, S.G., Ishimoto, N. and Strominger, J.L.
  Title
UDP-N-acetylglucosamine:polyribitol phosphate N-acetylglucosaminyltransferases from Staphylococcus aureus.
  Journal
Methods Enzymol. 8 (1966) 426-429.
Reference
2  [PMID:20185825]
  Authors
Xia G, Maier L, Sanchez-Carballo P, Li M, Otto M, Holst O, Peschel A
  Title
Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM.
  Journal
J. Biol. Chem. 285 (2010) 13405-15.
  Sequence
[sac:SACOL1043]
Reference
3  [PMID:25624472]
  Authors
Sobhanifar S, Worrall LJ, Gruninger RJ, Wasney GA, Blaukopf M, Baumann L, Lameignere E, Solomonson M, Brown ED, Withers SG, Strynadka NC
  Title
Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 112 (2015) E576-85.
  Sequence
[sac:SACOL1043]
Reference
4  [PMID:25697358]
  Authors
Koc C, Gerlach D, Beck S, Peschel A, Xia G, Stehle T
  Title
Structural and enzymatic analysis of TarM glycosyltransferase from Staphylococcus aureus reveals an oligomeric protein specific for the glycosylation of wall teichoic acid.
  Journal
J. Biol. Chem. 290 (2015) 9874-85.
  Sequence
[sac:SACOL1043]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.70
IUBMB Enzyme Nomenclature: 2.4.1.70
ExPASy - ENZYME nomenclature database: 2.4.1.70
BRENDA, the Enzyme Database: 2.4.1.70
CAS: 37277-71-7

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