KEGG   ENZYME: 2.4.1.86Help
Entry
EC 2.4.1.86                 Enzyme                                 

Name
N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase;
B3GALT1 (gene name);
uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase;
GalT-4;
UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosaminyl-(1->3)-D-galactosyl-(1->4)-D-glucosylceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase;
glucosaminylgalactosylglucosylceramide beta-galactosyltransferase;
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-R 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:R11714]
Reaction(KEGG)
R11714;
(other) R04610 R06006(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-R [CPD:C03518]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme transfers galactose from UDP-alpha-D-galactose to the 3-position of substrates with a non-reducing terminal N-acetyl-beta-D-glucosamine (beta-GlcNAc) residue. It can act on both glycolipids and glycoproteins, generating a structure known as the type 1 histo-blood group antigen precursor.
History
EC 2.4.1.86 created 1976, modified 2017
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Orthology
K07819  
beta-1,3-galactosyltransferase 1
K07820  
beta-1,3-galactosyltransferase 2
Genes
HSA: 
8707(B3GALT2) 8708(B3GALT1)
PTR: 
459710(B3GALT1) 469624(B3GALT2)
PPS: 
100969537(B3GALT2) 100986605(B3GALT1)
GGO: 
PON: 
100173654(B3GALT2) 100451414(B3GALT1)
NLE: 
100587051(B3GALT1) 100598456(B3GALT2)
MCC: 
704744(B3GALT1) 712334(B3GALT2)
MCF: 
101865991(B3GALT2) 102127118(B3GALT1)
CSAB: 
103217238(B3GALT1) 103230393(B3GALT2)
RRO: 
104655029(B3GALT1) 104655051 104671905(B3GALT2)
RBB: 
108526657(B3GALT1) 108541874(B3GALT2)
CJC: 
100394818(B3GALT2) 100414400(B3GALT1)
SBQ: 
101033633(B3GALT1) 101045625(B3GALT2)
MMU: 
26877(B3galt1) 26878(B3galt2)
RNO: 
366064(B3galt1) 686081(B3galt2)
CGE: 
100761765(B3galt1) 100766715(B3galt2)
NGI: 
103736704(B3galt2) 103747465(B3galt1)
HGL: 
101712201(B3galt1) 101726237(B3galt2)
CCAN: 
109679155(B3galt1) 109682476(B3galt2)
OCU: 
100338140(B3GALT1) 100348508(B3GALT2)
TUP: 
102486335(B3GALT1) 102494580(B3GALT2)
CFA: 
488386(B3GALT1) 607356(B3GALT2)
AML: 
100473736(B3GALT1) 100484200(B3GALT2)
UMR: 
103658170(B3GALT2) 103659526(B3GALT1)
FCA: 
101084131(B3GALT1) 101091170(B3GALT2)
PTG: 
102949445(B3GALT1) 102959610(B3GALT2)
AJU: 
106970309(B3GALT1) 106979251(B3GALT2)
BTA: 
539027(B3GALT1) 539815(B3GALT2)
BOM: 
102273719(B3GALT2) 102282371(B3GALT1)
BIU: 
109566873(B3GALT1) 109570453(B3GALT2)
PHD: 
102324103(B3GALT1) 102338524(B3GALT2)
CHX: 
102177200(B3GALT1) 102190625(B3GALT2)
OAS: 
101121025(B3GALT2) 101122666(B3GALT1)
SSC: 
100152554(B3GALT1) 100525885(B3GALT2)
CFR: 
102506488(B3GALT2) 102509415(B3GALT1)
CDK: 
105091056(B3GALT1) 105097313(B3GALT2)
BACU: 
103000382(B3GALT1) 103009179(B3GALT2)
LVE: 
103069039(B3GALT2) 103075987(B3GALT1)
ECB: 
100051213(B3GALT2) 100052244(B3GALT1)
EPZ: 
103565943(B3GALT2) 103567756(B3GALT1)
EAI: 
106843408(B3GALT1) 106848631(B3GALT2)
MYB: 
102245857(B3GALT1) 102257593(B3GALT2)
MYD: 
102759923(B3GALT2) 102771554(B3GALT1)
HAI: 
109380496(B3GALT2) 109390293(B3GALT1)
RSS: 
109445189(B3GALT1) 109454945(B3GALT2)
PALE: 
102895866(B3GALT1) 102898197(B3GALT2)
LAV: 
100663234(B3GALT2) 100671910(B3GALT1)
MDO: 
SHR: 
OAA: 
100077384(B3GALT1) 100082127(B3GALT2)
GGA: 
429027(B3GALT1) 769122(B3GALT2)
MGP: 
100543629(B3GALT2) 100544560(B3GALT1)
CJO: 
107316755(B3GALT1) 107317132(B3GALT2)
APLA: 
101797838(B3GALT1) 101802460(B3GALT2)
ACYG: 
106029956(B3GALT1) 106041600(B3GALT2)
TGU: 
100218797(B3GALT1) 100220053(B3GALT2)
GFR: 
FAB: 
PHI: 
102103706 102109748(B3GALT2) 102111511(B3GALT1)
PMAJ: 
107207453(B3GALT1) 107207931(B3GALT2)
CCW: 
FPG: 
101915951(B3GALT2) 101920291(B3GALT1) 106112240
FCH: 
102046778(B3GALT1) 102050143 102051968(B3GALT2)
CLV: 
102089471 102092086(B3GALT2) 102093422(B3GALT1)
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
100556689 100562203(b3galt1) 100562695(b3galt2)
PVT: 
110076874(B3GALT1) 110077421(B3GALT2) 110077942
PBI: 
103051546(B3GALT2) 103054338(B3GALT1)
GJA: 
107108379 107119638(B3GALT1) 107123228(B3GALT2)
XLA: 
XTR: 
NPR: 
DRE: 
100003996(si:ch73-195i19.3) 100331460 100333524 404633(b3galt2) 559521(b3galt1a) 565422 571003(b3galt1b) 798349(zgc:194330)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
103176378(b3galt1) 103180052(b3galt2)
BFO: 
SPU: 
SKO: 
DME: 
Dmel_CG30036(CG30036) Dmel_CG30037(CG30037) Dmel_CG33145(GalT1)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD25871(Dsim_GD25871) Dsimw501_GD25872(Dsim_GD25872)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
552398(B3GalT2)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
PHU: 
DPX: 
ISC: 
TUT: 
CEL: 
CELE_B0024.15(B0024.15)
CBR: 
NAI: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
OVI: 
NVE: 
ADF: 
TAD: 
MAW: 
PSOJ: 
 » show all
Taxonomy
Reference
1  [PMID:4335001]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a tetraglycosylceramide by a galactosyltransferase from rabbit bone marrow.
  Journal
J. Biol. Chem. 247 (1972) 1489-95.
Reference
2  [PMID:291963]
  Authors
Basu M, Presper KA, Basu S, Hoffman LM, Brooks SE.
  Title
Differential activities of glycolipid glycosyltransferases in Tay-Sachs disease: studies in cultured cells from cerebrum.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 4270-4.
Reference
3  [PMID:9582303]
  Authors
Amado M, Almeida R, Carneiro F, Levery SB, Holmes EH, Nomoto M, Hollingsworth MA, Hassan H, Schwientek T, Nielsen PA, Bennett EP, Clausen H
  Title
A family of human beta3-galactosyltransferases. Characterization of four members  of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.
  Journal
J. Biol. Chem. 273 (1998) 12770-8.
  Sequence
[hsa:8708 8707]
Reference
4  [PMID:10580128]
  Authors
Amado M, Almeida R, Schwientek T, Clausen H
  Title
Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.
  Journal
Biochim. Biophys. Acta. 1473 (1999) 35-53.
Reference
5  [PMID:10356986]
  Authors
Bardoni A, Valli M, Trinchera M
  Title
Differential expression of beta1,3galactosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa.
  Journal
FEBS. Lett. 451 (1999) 75-80.
  Sequence
[hsa:8708]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9073-46-5

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