KEGG   ENZYME: 2.4.1.86Help
Entry
EC 2.4.1.86                 Enzyme                                 

Name
N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase;
B3GALT1 (gene name);
uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase;
GalT-4;
UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosaminyl-(1->3)-D-galactosyl-(1->4)-D-glucosylceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase;
glucosaminylgalactosylglucosylceramide beta-galactosyltransferase;
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-R 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:R11714]
Reaction(KEGG)
R11714;
(other) R04610 R06006(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-R [CPD:C03518]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme transfers galactose from UDP-alpha-D-galactose to the 3-position of substrates with a non-reducing terminal N-acetyl-beta-D-glucosamine (beta-GlcNAc) residue. It can act on both glycolipids and glycoproteins, generating a structure known as the type 1 histo-blood group antigen precursor.
History
EC 2.4.1.86 created 1976, modified 2017
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Reference
1  [PMID:4335001]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a tetraglycosylceramide by a galactosyltransferase from rabbit bone marrow.
  Journal
J. Biol. Chem. 247 (1972) 1489-95.
Reference
2  [PMID:291963]
  Authors
Basu M, Presper KA, Basu S, Hoffman LM, Brooks SE.
  Title
Differential activities of glycolipid glycosyltransferases in Tay-Sachs disease: studies in cultured cells from cerebrum.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 4270-4.
Reference
3  [PMID:9582303]
  Authors
Amado M, Almeida R, Carneiro F, Levery SB, Holmes EH, Nomoto M, Hollingsworth MA, Hassan H, Schwientek T, Nielsen PA, Bennett EP, Clausen H
  Title
A family of human beta3-galactosyltransferases. Characterization of four members  of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.
  Journal
J. Biol. Chem. 273 (1998) 12770-8.
Reference
4  [PMID:10580128]
  Authors
Amado M, Almeida R, Schwientek T, Clausen H
  Title
Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.
  Journal
Biochim. Biophys. Acta. 1473 (1999) 35-53.
Reference
5  [PMID:10356986]
  Authors
Bardoni A, Valli M, Trinchera M
  Title
Differential expression of beta1,3galactosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa.
  Journal
FEBS. Lett. 451 (1999) 75-80.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9073-46-5

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