| Entry |
|
| Name |
nicotinate-nucleotide---dimethylbenzimidazole phosphoribosyltransferase;
nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase;
nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase;
nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase;
CobT;
nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase
|
| Class |
Transferases;
Glycosyltransferases;
Pentosyltransferases
 |
| Sysname |
nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase
|
| Reaction(IUBMB) |
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate [RN: R04148]
|
| Reaction(KEGG) |
|
| Substrate |
beta-nicotinate D-ribonucleotide [CPD: C01185];
5,6-dimethylbenzimidazole [CPD: C03114]
|
| Product |
nicotinate [CPD: C00253];
alpha-ribazole 5'-phosphate [CPD: C04778]
|
| Comment |
Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate. The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin-biosynthesis pathway and is a substrate for EC 2.7.8.26, adenosylcobinamide-GDP ribazoletransferase [4]. It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73, alpha-ribazole phosphatase.
|
| Pathway |
| Porphyrin and chlorophyll metabolism | | Metabolic pathways |
|
| Orthology |
| nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase |
|
| Genes |
RCU: | | ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EBT: | | STY: | | STT: | | SEX: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | YEN: | | YEP: | | YEY: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | PLU: | | PAY: | | ESC: | | EAE: | | EAR: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | EIC: | | ETR: | | ETD: | | ETC: | | XBO: | | XNE: | | RAH: | | RAQ: | | RAA: | | MMK: | | ROR: | | EBF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XCI: | | FAU: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | PPR: | | VAN: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | PDR: | | CJA: | | AVN: | | AVL: | | AVD: | | PCR: | | PRW: | | ACD: | | ACB: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ACC: | | SON: | | SFR: | | SAZ: | | SBL: | | SBM: | | SBN: | | SBP: | | SBT: | | SBS: | | SBB: | | SLO: | | SPC: | | SHP: | | SSE: | | SPL: | | SHE: | | SHM: | | SHN: | | SHW: | | SHL: | | SWD: | | SWP: | | SVO: | | CPS: | | PHA: | | PAT: | | SDE: | | MAQ: | | MHC: | | MBS: | | GAG: | | GPS: | | TTU: | | MCA: | | MMT: | | MAH: | | MEJ: | | ALV: | | TVI: | | TMB: | | AEH: | | HHA: | | TKM: | | TNI: | | HCH: | | HEL: | | ABO: | | ADI: | | MMW: | | MME: | | MPC: | | TOL: | | TAU: | | OCE: | | SAGA: | | GPB: | | CVI: | | LHK: | | PSE: | | RSO: | | RSC: | | RSL: | | RSN: | | RPI: | | RPF: | | REU: | | REH: | | RME: | | CTI: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPZ: | | BPQ: | | BTE: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BGD: | | BYI: | | BUK: | | BPX: | | RFR: | | POL: | | PNA: | | AAV: | | AJS: | | DIA: | | AAA: | | ACK: | | DAC: | | DEL: | | VAP: | | VPE: | | CTT: | | ADN: | | ADK: | | RTA: | | MPT: | | HAR: | | MMS: | | HSE: | | LCH: | | RGE: | | NII: | | EBA: | | AZO: | | AZA: | | DAR: | | TMZ: | | DSU: | | TBD: | | MFA: | | MMB: | | MEH: | | MEI: | | MEP: | | APP: | | GSU: | | GSK: | | GME: | | GUR: | | GLO: | | GBM: | | GEO: | | GEM: | | GEB: | | PCA: | | PPD: | | DVU: | | DVL: | | DVM: | | DVG: | | DDE: | | DDS: | | DDN: | | DMA: | | DSA: | | DAS: | | DAF: | | DHY: | | DPI: | | DBA: | | DPS: | | DAK: | | DPR: | | DSF: | | DOL: | | DAL: | | DAT: | | DTO: | | MSD: | | SCL: | | HOH: | | DAO: | | DTI: | | SFU: | | DBR: | | HMR: | | MLO: | | MCI: | | MOP: | | MAM: | | MES: | | PLA: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | RHI: | | SFH: | | SFD: | | ATU: | | ARA: | | AVI: | | AGR: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | LCC: | | BME: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMF: | | BMB: | | BMC: | | BAA: | | BMS: | | BSI: | | BMT: | | BSV: | | BOV: | | BCS: | | BSK: | | BMR: | | BPP: | | OAN: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | AOL: | | BHE: | | BQR: | | BBK: | | BTR: | | BGR: | | BCD: | | BAUS: | | BVN: | | XAU: | | AZC: | | SNO: | | MEX: | | MEA: | | MDI: | | MCH: | | MRD: | | MET: | | MPO: | | MNO: | | BID: | | MSL: | | HDN: | | HMC: | | RVA: | | PHL: | | MSC: | | CCR: | | CCS: | | CAK: | | CSE: | | SIL: | | SIT: | | RSP: | | RSH: | | RSQ: | | RSK: | | RCP: | | JAN: | | RDE: | | RLI: | | PDE: | | DSH: | | PSF: | | PGA: | | PGL: | | OAT: | | OAR: | | HNE: | | HBA: | | NAR: | | NPP: | | SPHM: | | SJP: | | SCH: | | GOH: | | GBE: | | AMV: | | GDI: | | GDJ: | | GXY: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | RRU: | | RRF: | | RCE: | | RPM: | | MAG: | | AZL: | | ALI: | | ABS: | | TMO: | | APB: | | PGV: | | MGM: | | DIN: | | BHA: | | BCG: | | BPF: | | BMQ: | | BMD: | | BMH: | | GKA: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | AFL: | | LSP: | | BBE: | | PJD: | | GYM: | | PPY: | | PPM: | | PPO: | | PMS: | | PMQ: | | PMW: | | PTA: | | TCO: | | AAC: | | AAD: | | BTS: | | SIV: | | SSA: | | LRE: | | LRF: | | LRU: | | PCE: | | CAC: | | CAE: | | CAY: | | CPE: | | CPF: | | CPR: | | CTC: | | CNO: | | CTH: | | CTX: | | CBK: | | CBN: | | CBT: | | CBE: | | CKL: | | CKR: | | CPY: | | CCE: | | CLJ: | | CSH: | | CCB: | | CLS: | | CLB: | | CCL: | | CAD: | | CSR: | | CDF: | | CDC: | | CDL: | | CDG: | | CST: | | AMT: | | SWO: | | SLP: | | DSY: | | DHD: | | DDH: | | DDL: | | DRM: | | DAE: | | DCA: | | DKU: | | DRU: | | PTH: | | DAU: | | TJR: | | SGY: | | DOR: | | DAI: | | DMI: | | DED: | | DEC: | | HMO: | | ERE: | | ERT: | | ERA: | | ELM: | | AWO: | | BFI: | | CLE: | | RHO: | | RIX: | | RIM: | | CCT: | | RUM: | | ROB: | | RTO: | | FPR: | | FPA: | | SAY: | | SAP: | | BPRS: | | CHY: | | TEP: | | TAE: | | MTA: | | ADG: | | TPZ: | | TOC: | | MAS: | | HAS: | | HPK: | | AAR: | | HHL: | | VPR: | | SSG: | | SRI: | | MED: | | MHG: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTG: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MBO: | | MBB: | | MBT: | | MBM: | | MBK: | | MAF: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MLE: | | MLB: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSM: | | MSG: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | ASD: | | CGL: | | CGB: | | CGU: | | CGT: | | CEF: | | CDI: | | CDP: | | CDH: | | CDT: | | CDE: | | CDR: | | CDA: | | CDZ: | | CDB: | | CDS: | | CDD: | | CDW: | | CDV: | | CJK: | | CUR: | | CUA: | | CAR: | | CKP: | | CPU: | | CPL: | | CPG: | | CPP: | | CPK: | | CPQ: | | CPX: | | CPZ: | | COR: | | COP: | | COD: | | COS: | | COI: | | COE: | | COU: | | CRD: | | CUL: | | CUC: | | CUE: | | CVA: | | CHN: | | CCN: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | GOR: | | TPR: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | KSK: | | ICA: | | PFR: | | PBO: | | MPH: | | NCA: | | KFL: | | TFU: | | NDA: | | NAL: | | TCU: | | SRO: | | FRA: | | FRE: | | FRI: | | FAL: | | FSY: | | ACE: | | NML: | | GOB: | | BSD: | | MMAR: | | KRA: | | SEN: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | SNA: | | RXY: | | AFO: | | AYM: | | SHI: | | TDE: | | TAZ: | | TPI: | | SSM: | | STA: | | SCD: | | LIL: | | LIE: | | LIC: | | LBJ: | | LBL: | | LBI: | | LBF: | | SBU: | | SGP: | | ACM: | | GMA: | | CTM: | | BFR: | | BFS: | | BFG: | | BVU: | | BHL: | | PGI: | | PGN: | | PGT: | | PAH: | | PDI: | | PPN: | | OSP: | | TFO: | | PRU: | | CPI: | | NKO: | | EVI: | | DFE: | | FAE: | | FJO: | | FPS: | | FCO: | | FIN: | | WVI: | | OHO: | | FNU: | | LBA: | | STR: | | IPO: | | AMU: | | GAU: | | PLM: | | IPA: | | SACI: | | TLI: | | SBR: | | CTE: | | CPC: | | CCH: | | CPH: | | CPB: | | CLI: | | PVI: | | PLT: | | PPH: | | PAA: | | CTS: | | DET: | | DEH: | | DEB: | | DEV: | | DEG: | | DMC: | | DMD: | | DLY: | | RRS: | | RCA: | | CAU: | | CAG: | | CHL: | | HAU: | | CAP: | | DRA: | | DGE: | | DDR: | | DMR: | | DPT: | | DGO: | | DPD: | | TRA: | | TTH: | | TTJ: | | TTS: | | TTL: | | TSC: | | THC: | | TOS: | | MRB: | | MRE: | | MSV: | | OPR: | | MHD: | | TLE: | | TTA: | | TME: | | TAF: | | FNO: | | FPE: | | KOL: | | TYE: | | NDE: | | LFC: | | LFI: | | DDF: | | DAP: | | CNI: | | TID: | | MOX: | | » show all
 |
| Reference |
|
| Authors |
FRIEDMANN HC. |
| Title |
PARTIAL PURIFICATION AND PROPERTIES OF A SINGLE DISPLACEMENT TRANS-N-GLYCOSIDASE. |
| Journal |
J. Biol. Chem. 240 (1965) 413-8. |
| Organism |
Propionibacterium shermanii |
| Reference |
|
| Authors |
Friedmann HC, Fyfe JA. |
| Title |
Pseudovitamin B 12 biosynthesis. Enzymatic formation of a new adenylic acid, 7-alpha-D-ribofuranosyladenine 5'-phosphate. |
| Journal |
J. Biol. Chem. 244 (1969) 1667-71. |
| Organism |
Clostridium sticklandii |
| Reference |
|
| Authors |
Fyfe JA, Friedmann HC. |
| Title |
Vitamin B 12 biosynthesis. Enzyme studies on the formation of the alpha-glycosidic nucleotide precursor. |
| Journal |
J. Biol. Chem. 244 (1969) 1659-66. |
| Organism |
Propionibacterium shermanii, Clostridium sticklandii |
| Reference |
|
| Authors |
Cameron B, Blanche F, Rouyez MC, Bisch D, Famechon A, Couder M, Cauchois L, Thibaut D, Debussche L, Crouzet J. |
| Title |
Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5'-phosphate) synthase. |
| Journal |
J. Bacteriol. 173 (1991) 6066-73. |
| Organism |
Pseudomonas denitrificans |
| Reference |
|
| Authors |
Cheong CG, Escalante-Semerena JC, Rayment I. |
| Title |
Structural investigation of the biosynthesis of alternative lower ligands for cobamides by nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella enterica. |
| Journal |
J. Biol. Chem. 276 (2001) 37612-20. |
| Organism |
Salmonella enterica |
| Reference |
|
| Authors |
Cheong CG, Escalante-Semerena JC, Rayment I. |
| Title |
Capture of a labile substrate by expulsion of water molecules from the active site of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enterica. |
| Journal |
J. Biol. Chem. 277 (2002) 41120-7. |
| Organism |
Salmonella enterica |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37277-76-2 |